Sativa marijuana is peaty
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@CrumblingCookie said in Sativa marijuana is peaty:
but CBG is also a 5-HT1A antagonist at 52nM: Not "peaty" at all.
THC again is serotonergic and exhibits those detrimental effects on gonadal functions, androgenic hormones and fertility etc. as already mentioned before by the others.Sure, but in the context of classical cannabis genetics CBG % was very low, and THC % also. Terpenes could feasibly mitigate any serotonergic and metabolic effects. A coffee and tobacco would do the rest!
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@CrumblingCookie said in Sativa marijuana is peaty:
So pushing THC and prohibiting or muddling with clean tobacco smoking fits well into the trend of a widely known general agenda.
Yup, similar to how traditional gruit was replaced with hops beer. Gruit was apparently consumed by people of all ages and regions had different ingredients.
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I find THCA very useful for pain relief.
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Didn't I read that vaping was the least estrogenic way to get high? Burning releases all of the harmful compounds, etc.
My blanket statement is marijuana activates stressors / gene interactions that can trigger psychosis, schizo; depression, etc, at worst, and at best can relieve glaucoma, anorexia, and certain autism cases.
In between is the bell curve where like 90% of people are just giggling and getting lost in mental loops. I declare it: not Peaty.
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@Ecstatic_Hamster
Have you ever looked into myrrh oil and eugenol? Both have useful analgesic qualities which would synergise very well with cannabinoids. There's also analgesic terpenes from essential oils such as myrcene and bisabolene. -
total cope, peat had more positive things to say about cocaine than weed
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cry
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I abused the crap out of cannabis daily for too many years and stopping cold Turkey was a horrendous experience. I think the reliance on the boost in pregnanalone made quitting such a bad experience, like getting my foundation ripped out from under me. After quitting I had daily panic attacks from nothing for over a month with extreme nausea. And anxiety that lasted another 6 months or so.
So glad to make it out the other side of that. Maybe a couple puffs throughout the week is fine but I enjoyed the escape too much to moderate my use.
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For anyone interested ray peat was asked (and replied) in an email:
Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-141957Regarding CBD:
Hi dr. Peat,
I know that you don't really like cannabinoids and think that the hype around cannabis for cancer is exagerated but I wanted to know what you think about CBD? I think that you said that cannabinoids where involved in fatty acid synthesis and nitric oxide? Is that the case for CBD?
Thank you very much!
It can probably be helpful for lowering nitric oxide in some situations, but there’s some evidence that it increases prostaglandins, which could be harmful in a person whose tissues have a lot of PUFA. The acidic form, CBDA, seems likely to be more broadly protective.
J Toxicol Sci. 2014;39(5):711-6.
Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells.
Takeda S1, Okazaki H, Ikeda E, Abe S, Yoshioka Y, Watanabe K, Aramaki H.
Metastases are known to be responsible for approximately 90% of breast cancer-related deaths. Cyclooxygenase-2 (COX-2) is involved not only in inflammatory processes, but also in the metastasis of cancer cells; it is expressed in 40% of human invasive breast cancers. To comprehensively analyze the effects of cannabidiolic acid (CBDA), a selective COX-2 inhibitor found in the fiber-type cannabis plant (Takeda et al., 2008), on COX-2 expression and the genes involved in metastasis, we performed a DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are invasive breast cancer cells that express high levels of COX-2, treated with CBDA for 48 hr at 25 µM. The results obtained revealed that COX-2 and Id-1, a positive regulator of breast cancer metastasis, were down-regulated (0.19-fold and 0.52-fold, respectively), while SHARP1 (or BHLHE41), a suppressor of breast cancer metastasis, was up-regulated (1.72-fold) and CHIP (or STUB1) was unaffected (1.03-fold). These changes were confirmed by real-time RT-PCR analyses. Taken together, the results obtained here demonstrated that i) CBDA had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and ii) CBDA may possess the ability to suppress genes that are positively involved in the metastasis of cancer cells in vitro. -
@16charactersitis and “could be harmful in” “a person whose tissues have a lot of PUFA” describes most of us