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    Glucose loading cures everything?

    Bioenergetic Development
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    • yerragY
      yerrag @S.Holmes
      last edited by yerrag

      @S-Holmes said in Glucose loading cures everything?:

      I haven't quite figured out how or why the brain downregulates sugar usage following every stress (any kind of stress). Stress seems to trigger lipolysis (vs glycolysis) and the damage is CUMULATIVE. Is this why stress kills? I've ordered his latest book. Hopefully he addresses this in depth.

      I don't agree with framing low sugar usage by the brain to be caused by the brain downregulating sugar usage. The brain can keep sending signals for sugar to be delivered to it by blood, as well as oxygen, but it can only direct but the cardiovascular system is the one that fulfills that directive, subject to its state of health. If the tissues cannot absorb glucose because say potassium is deficient, there is nothing the brain can do. Likewise with oxygen, if CO2 is deficient in blood, hemoglobin will not release oxygen to the brain cells.

      What specific stress are you referring to that triggers lipolysis? That presupposes stress is needed to trigger lipolysis. But what if lipolysis is just a regular process to release fats from fat stores to be used by fatty-acid oxidation as part of the body's ability to use different energy pathways (I.e. sugar oxidation and fat oxidation) to optimize energy production and conserve sugar for use by the brain?

      In fact, one thing insulin does is to inhibit lipolysis. Which means that when blood sugar levels are stable and normal, and insulin is not produced, lipolysis goes on as a normal process in the body.

      And this may be the reason why people with good and stable blood sugar levels do not get overweight nor obese, as they are constantly using up their fat stores for energy, and their fat stores do not accumulate.

      Temporal thinking is the faculty that’s
      engaged by an enriched environment, but it’s
      wrong to call it “thinking,” because it’s simply
      the way organisms exist... - Ray Peat Nov 2017 Newsletter

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      • yerragY
        yerrag @S.Holmes
        last edited by

        @S-Holmes

        Gluconeogenesis isn't used in the digestive process.

        Complex sugars are broken down to simple sugars down to becoming glucose, which is absorbed by the small intestine, and assimilated into blood as blood sugar.

        Gluconeogenesis is when protein is broken down into glucogenic amino acids, which are further broken down to be used to make glucose. I believe the liver, and to some extent, the kidneys, does this.

        Temporal thinking is the faculty that’s
        engaged by an enriched environment, but it’s
        wrong to call it “thinking,” because it’s simply
        the way organisms exist... - Ray Peat Nov 2017 Newsletter

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        • InsomniacI
          Insomniac @yerrag
          last edited by

          This post is deleted!
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          • P
            Peatful
            last edited by

            Just visited the RPF

            So bizarre

            The questions in this thread have again mostly been discussed by Ray
            If not directly
            Meaning not told exactly “how to do it”
            This is where we are to perceive think act

            From my personal experience
            And I healed from extremely poor health to now the greatest health I’ve ever had
            Sugar was absolutely foundational
            A foundation is what we build upon

            But
            Im here to say
            As I said over there

            Stress hormones desensitize the insulin receptor
            From birth to now, most of us have had some sort of stress that is shaped our experience of our health
            With chronic stress comes many things all of which desensitizes the insulin receptor

            When you reintroduce sugar your body is essentially already in an insulin resistant state
            The stress hormones flooding your system overtime have desensitized the insulin receptor so insulin cannot drive glucose into the cell anymore….

            I point this out because the more I used this wonderful “nutrient”
            The more I was able to handle it and really reap the benefits of using it not only in relatively large quantities- my ability to utilize it as a therapeutic tool only got better and better
            But the beginning was rough
            Really rough
            Due to my stressed metabolic state

            Anyway
            Just stunned that Ray isn’t understood nor acknowledged on his own forum
            I grieve that shit

            Please listen to him here
            He addresses a lot iirc

            A prophet
            A genius
            And a friend

            Youtube Video

            The further society drifts from the truth the more it will hate those who speak it.

            SD

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            • B
              bot-mod @Peatful
              last edited by

              I was in awe having a scroll of it this morning. Their power struggles and appeals to spertise occasionally gets a bit shakespearian. Someone could probably write an entertaining novel about RPF.

              Aside from that Ms Peatful. I know the feelings. Beside and probably not distinct from the science.

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              • B
                bot-mod @yerrag
                last edited by

                All a bit strange hey Mr Yerrag. I find myself affirm to your observation.

                Meanwhile, I get the feeling there's something in this. I'll have to read around quite a lot, enjoy surrounding conversation and sleep well I guess. All I can do right now is speculate. That the fructose is unwelcome to him for myocardial reasons and the glucose still benefits for structural and therefore metabolic reasons. Probably not without personal consequence. But at least it begs some questions.

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                • S
                  S.Holmes @Peatful
                  last edited by

                  @Peatful Could you expound on "rough"? I had a very strange burning pain from my neck to the bottom of my ribs yesterday (right side). I put an aspirin under my tongue and took a homeopathic remedy to treat stroke, just in case. It lasted about 15 minutes and then I was fine.

                  If not for Dr.Peat I wouldn't have given the sucrose protocol a second look. I think he saved my life, but I still have lingering issues, and weight gain which is difficult because I was very thin my entire life. So I'm willing to try anything to feel better. I've been on Nathan Hatch's protocol for a few months, and it was helpful but still didn't quite get me "there." (I still use some of the things he suggests.)

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                  • S
                    S.Holmes @yerrag
                    last edited by

                    @yerrag Right, I was referring to fuel being obtained from protein or fat. Simple sugars are absorbed in the stomach, not the intestines. That's what I meant by bypassing the digestive process.

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                    • E
                      evan.hinkle @Insomniac
                      last edited by

                      @Insomniac but here’s the kicker, my blood glucose levels are lower. Where I was spiking to 150 after a meal I’m now spiking to 125. Every time I check my blood glucose it’s 20-30 points lower than my typical readings without dextrose.

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                      • P
                        Peatful @S.Holmes
                        last edited by

                        @S-Holmes said in Glucose loading cures everything?:

                        @Peatful Could you expound on "rough"? I had a very strange burning pain from my neck to the bottom of my ribs yesterday (right side). I put an aspirin under my tongue and took a homeopathic remedy to treat stroke, just in case. It lasted about 15 minutes and then I was fine.

                        If not for Dr.Peat I wouldn't have given the sucrose protocol a second look. I think he saved my life, but I still have lingering issues, and weight gain which is difficult because I was very thin my entire life. So I'm willing to try anything to feel better. I've been on Nathan Hatch's protocol for a few months, and it was helpful but still didn't quite get me "there." (I still use some of the things he suggests.)

                        Yes
                        I had odd symptoms
                        Troubling ones
                        But transient

                        I had significant weight gain
                        But
                        That was not about the sugar or the foods
                        The weight gain reflected the damage already done in my body

                        It was so much fluid
                        And
                        As said above
                        With any history of restriction or stress
                        You will start with your cells unable to get the sugar in
                        But it gets better
                        Your body has to relearn

                        Maybe this will help give you an idea?

                        Im around today
                        Jyst need to run now

                        Thx

                        https://raypeatforum.com/community/threads/reintroducing-peaty-eating-after-very-low-carb-low-calorie.50945/

                        The further society drifts from the truth the more it will hate those who speak it.

                        SD

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                        • S
                          S.Holmes @yerrag
                          last edited by

                          @yerrag Well, the doctor admits that some of the protocol is based on theory...such as how quickly and preferentially the glucose appears to make it's way to the brain, within a couple of minutes! I believe that was the theory he said he would need spinal tap volunteers for. Who would sign up for that??? Theories, in my opinion, should be put to the test. He has been testing it out for a while now, with amazing successes. I'm just doing my part.

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                          • S
                            S.Holmes @evan.hinkle
                            last edited by

                            This post is deleted!
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                            • S
                              S.Holmes @evan.hinkle
                              last edited by

                              @evan-hinkle said in Glucose loading cures everything?:

                              @Insomniac but here’s the kicker, my blood glucose levels are lower. Where I was spiking to 150 after a meal I’m now spiking to 125. Every time I check my blood glucose it’s 20-30 points lower than my typical readings without dextrose.

                              THIS!!!

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                              • B
                                bot-mod @evan.hinkle
                                last edited by

                                I'd ask for your urinary volumes throughout the day but I'm not going to push my luck. Or be that weird.

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                                • S
                                  S.Holmes @Peatful
                                  last edited by

                                  @Peatful Yes, very helpful, thank you.

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                                  • InsomniacI
                                    Insomniac @evan.hinkle
                                    last edited by Insomniac

                                    This post is deleted!
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                                    • E
                                      evan.hinkle @Insomniac
                                      last edited by

                                      @Insomniac the protocol is to increase dextrose until symptoms abate and then stay there for a period of a few months. I’m not against trying a one time dose of that nature, but I’m working on a giant treehouse today so I won’t be able to try til later in the evening.

                                      InsomniacI S 2 Replies Last reply Reply Quote 0
                                      • E
                                        evan.hinkle @bot-mod
                                        last edited by

                                        @ThinPicking I haven’t tracked, but I’ll say this, I don’t urinate very frequently because I don’t drink a ton of fluids. Maybe three times a day, not particularly dark, nor clear. What’s the theory you’re thinking here?

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                                        • InsomniacI
                                          Insomniac @evan.hinkle
                                          last edited by Insomniac

                                          This post is deleted!
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                                          • B
                                            bot-mod @evan.hinkle
                                            last edited by

                                            The volume, specific gravity and/or TDS would tell you a lot. But at the same time, your sensation of your own wellbeing is paramount here. If you're feeling good, let that be.

                                            I like these kinds of dollar metrics for the buck accessibility. Refractometer, TDS meters, stethoscopes, sensitive scales, bioimpedance meters, HRV, BP, this kind of thing. No million buck labs filled with nerdoids.

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