Glucose loading cures everything?

[Peatful]

@tubert said in Glucose loading cures everything?:

@Peatful Could you please explain how you incorporated high quantities of sucrose into your diet? Thanks

Hey there, this is voice recognition.

I would love to help out
But context is so important around any health data in my opinion

So rather than me, spitting out a bunch of information
Do you wanna just tell me kind of where you’re at or what specifically are you looking to heal?

Dietary history here is paramount as well as just where your health lands today

[Peatful]

@S-Holmes said in Glucose loading cures everything?:

@S-Holmes said in Glucose loading cures everything?:

@Peatful Could you expound on "rough"? I had a very strange burning pain from my neck to the bottom of my ribs yesterday (right side). I put an aspirin under my tongue and took a homeopathic remedy to treat stroke, just in case. It lasted about 15 minutes and then I was fine.

If not for Dr.Peat I wouldn't have given the sucrose protocol a second look. I think he saved my life, but I still have lingering issues, and weight gain which is difficult because I was very thin my entire life. So I'm willing to try anything to feel better. I've been on Nathan Hatch's protocol for a few months, and it was helpful but still didn't quite get me "there." (I still use some of the things he suggests.)

Apologies...I meant glucose protocol, not sucrose.

Hey
All sugars turn into glucose in our body
Lactose, dextrose, sucrose etc

Yes?

[S.Holmes]

@Peatful The gist of the protocol is to skip all of the various conversions and provide glucose directly to the brain.

[Peatful]

@S-Holmes said in Glucose loading cures everything?:

@Peatful The gist of the protocol is to skip all of the various conversions and provide glucose directly to the brain.

“Protocol”
Please note

There is nothing new under the sun

Although I haven’t read nor watched this guy
This is just “marketing”

The title of the thread is: Glucose loading cures everything?

All sugars turn into glucose
Nothing magical about dextrose as far as I understand Peat

[S.Holmes]

@S-Holmes I love that those little Smarties candies are made with 100% dextrose/glucose. 1 roll contains 6 or 7 grams of dextrose. Someone named them appropriately it seems. I bought some in bulk from Amazon. My little grandbabies are always getting bumps and bruises out here on our farm so Smarties (and Arnica montana) to the rescue!

[Peatful]

@S-Holmes said in Glucose loading cures everything?:

@S-Holmes I love that those little Smarties candies are made with 100% dextrose/glucose. 1 roll contains 6 or 7 grams of dextrose. Someone named them appropriately it seems. I bought some in bulk from Amazon. My little grandbabies are always getting bumps and bruises out here on our farm so Smarties (and Arnica montana) to the rescue!

This is great
Load up and enjoy
Unless they are loaded with citric acid

For reference
Just in case

https://raypeatforum.com/community/threads/manufactured-citric-acid-is-a-powerful-inflammatory-allergy-agent.41954/

[S.Holmes]

@Peatful You'll need to go back and check out some of the links. There is definitely a difference.

Georgi posted a study, which I believe I shared the link to in this thread, about glucose being used therapeutically in ALS. Why do mostly athletes develop ALS? Traumatic brain injuries are the likely cause. But Dr. Stephens says even milder bumps on the head that aren't obviously concussive will cause irreversible (via normal healing mechanisms) glucose limiting effects on the brain. Pure dextrose seems to be healing these brain injuries.

[Peatful]

@S-Holmes

This?

https://raypeatforum.com/community/threads/high-sugar-diet-prolongs-survival-in-als-patients.3301/

A high SUGAR diet
And thar happens to be dextrose?

It’s about sugar
Not dextrose per say as far as I understand

Experiment
Have fun
Enjoy the journey

[S.Holmes]

@Peatful

"A 2019 study from the University of Arizona found that increasing GLUCOSE DELIVERY to motor neurons affected by amyotrophic lateral sclerosis (ALS) may help patients live longer and function better. ALS is a progressive neurodegenerative disease that causes increased metabolic activity, known as hypermetabolism. When ALS-affected neurons are given more GLUCOSE, they can convert it into energy to meet their abnormally high energy demands. This may help improve mobility and increase survival rates.
Other research suggests that a higher GLUCOSE-based diet may also help slow ALS progression by preventing protein misfolding. Misfolded proteins can accumulate in the brains of ALS patients, which may contribute to disease progression."

[Peatful]

@S-Holmes mm-hmm

[yerrag]

@Peatful

I don't think sucrose turns into glucose. Half of sucrose is glucose. Half of it is fructose. Both are metabolized. There are other sugars out there like lactose. It is also metabolized. But there are some that aren't.

Ray has spoken highly n earlier articles of fructose. In the way that it is more easily absorbed and metabolized. So clearly, it does not turn into glucose as you would say it does.

[S.Holmes]

@yerrag
"Data from the present study show that ∼90% of dietary fructose is converted into glucose and other metabolites, such as lactate and glycerate, by the small intestine before it reaches the liver. Feb 23, 2018"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032988/

[Peatful]

@yerrag said in Glucose loading cures everything?:

@Peatful

I don't think sucrose turns into glucose. Half of sucrose is glucose. Half of it is fructose. Both are metabolized. There are other sugars out there like lactose. It is also metabolized. But there are some that aren't.

Ray has spoken highly n earlier articles of fructose. In the way that it is more easily absorbed and metabolized. So clearly, it does not turn into glucose as you would say it does.

Yes

Im not talking about the processing

Fructose differs in structure etc from lactose obviously
Etc etc etc

Im saying
We drink fructose (once processed)
“Oh. Glucose to our brain.”
We drink lactose (once processed)
“Oh. Glucose to our brain”

But of course they have different properties
They are two different “foods”

Now
This differs from starch vs sugar
Although starchy carbs “turn to glucose”
Very different

[Peatful]

Just thought of something

Im saying mono and disaccharides are the same once turned to glucose….
Same energy per gram….

Lactose.
Fructose
Sucrose
Etc

I stand corrected if im wrong here

[yerrag]

@Insomniac said in Glucose loading cures everything?:

@yerrag said in Glucose loading cures everything?:

How is the digestive process bypassed? I fail to see the logic. One way the digestive process is bypassed is by IV feeding. But I don't know if this is what you mean.

This is my main issue with the whole concept. Stephens is claiming isolated dextrose has special properties however it raises glucose in the blood just like food does. So how can the glucose put there from corn sugar do something different from glucose put there from food or even an IV?
I hear you. I would have to say dextrose has the same properties as glucose and that there is no difference I'm how the body metabolizes it, both being simple sugars and in the form of 100% glucose. So another mechanism is at work that disposes the body to more quickly metabolize dextrose.
The only difference I can think of is the rate of glucose entry into the blood could be faster and have a greater concentration peak than could be achieved by food under ordinary conditions especially at higher doses of more than 200 grams people are spiking their glucose through the roof but at least it would be doing something different so you can consider a medicinal effect.

If you're familiar with a blood sugar test that was widely available until the 90s (the 5hr oral glucose tolerance test, since replaced by the much less useful hokey pokey HbA1c), a 75gr bolus of glucose is taken after an overnight fast and blood sugar readings are taken every hour. This test was done under supervision because some people (with blood sugar regulation problems) could faint halfway through it because their blood sugar would drop so low.

I ask myself how much more this fainting would happen if a 200g bolus were taken. Yet this risk in not even mentioned by Dr. Stephens. And I wonder why.

It is as if no such event has ever occurred in Dr. Stephen's trials. It's as if all people, with a wide range of blood sugar regulation issues from none to extremely tending to become hypoglycemic (I was one before I fixed myself), are not liable to faint from hypoglycemia.

So, I'm curious as to why. It's as if taking dextrose flips a switch that taking glucose wouldn't - that suddenly everything is hunky dory where very large dextrose intakes (akin to a flood of biblical proportions) would easily be absorbed and metabolized, with nary a problem.

The only answer I could think of is that the body is equipped to handle a sudden deluge of glucose through the polyol pathway, which converts glucose to fructose, and makes possible the large absorption and metabolism of a sugar glucose possible thru its conversion to fructose.

In addition, the body would be triggered to release insulin in large quantities which would inhibit lipolysis, which would clear the way for fatty acid oxidation to be suppressed (given fatty acids in blood would be depleted), paving the way for a high proportion of energy to be produced via mitochondrial oxidation.

At the same time, the pancreas' beta cells would become fully functional with its stem cell exposed to glucose as its stem cells turn into functional beta cells that produce insulin.

Altogether, this transforms the body from a moribund state of low or nonexistent sugar metabolism to a fully alive highly metabolic state over time during therapy. With the caveat that the body has enough stores of nutrients such as vitamin A, D, magnesium to accompany the higher metabolic state's use of more nutrients.

But it is hard to conceive that no such groundwork has been considered and nutrients made available in the therapy, to ensure this transformation happens. And yet people are reporting blood sugar improvements such as that of @evan-hinkle 's blood sugar values.

[yerrag]

@Peatful

But you're still insisting fructose and lactose turns into glucose before it reaches the brain. I don't know about lactose, but fructose does not have to turn intobglucose to be absorbed and metabolized.

Unless I'm reading wrongly in Peat's early articles on fructose.

[Peatful]

@yerrag said in Glucose loading cures everything?:

@Peatful

But you're still insisting fructose and lactose turns into glucose before it reaches the brain. I don't know about lactose, but fructose does not have to turn intobglucose to be absorbed and metabolized.

Unless I'm reading wrongly in Peat's early articles on fructose.

From my understanding
Mono (ie: fructose) and di (ie: lactose)
Both are converted into glucose before reaching the brain

Starches different story of course

If dextrose is mono
And it does differ from di
Maybe that’s why it’s recommended by this guy?

[Insomniac]

This post is deleted!

[bot-mod]

@ThinPicking said in Glucose loading cures everything?:

But there's some sort of concert going on.

@ThinPicking said in Are Polls a Good Idea?:
Is it actually possible to substitute in either direction. Maybe just a temporary lack of control and engagement in some. Many ways a person can delude themselves. Misappropriate their condition and capability.

I don't know. So this isn't an objection. I'll be creating some posts on the subject at some point.

https://www.mdpi.com/1424-8220/22/23/9115
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075501/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002343/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.040499
https://www.sciencedirect.com/science/article/abs/pii/S0306987719307145
https://www.sciencedirect.com/science/article/pii/S1568163721002865
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00278/full

For the liver fixation of the Vitamin A toxicity crowd.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981187/

For their aversion to fructose.

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.695486/full

[yerrag]

@evan-hinkle said in Glucose loading cures everything?:

@Insomniac fructose converts to glucose in an oxidative metabolism. This is what I think is the missing piece for everyone here and at the RPF.

No. Fructose does not need conversion to glucose to be metabolized. Actually, fructose is more easily absorbed and metabolized than glucose. You can find many articles in his website (or used to be, if his website is gone) www. raypeat.com about fructose

So, you need oxidative phosphorylation, (thyroid supplementation) or glucose. 2 options, same outcome.

Not 'or' but 'and' glucose ( and oxygen, and more).