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    Reversal of hair loss in Mice with “sugar gel”

    Scheduled Pinned Locked Moved Literature Review
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    • LetTheRedeemedL Offline
      LetTheRedeemed @OliverCloasov
      last edited by LetTheRedeemed

      @OliverCloasov @AinmBeo @Hearthfire
      I'm open to a group buy if anyone of us can find a supplier to private individuals.

      or, what if we all beseeched Georgi to make an experimental cosmetic in a one off batch and we be his guinea pigs? 😄

      O 1 Reply Last reply Reply Quote 0
      • ? Offline
        A Former User @OliverCloasov
        last edited by

        @OliverCloasov it increases NO so according to danny roddy it is le bad

        O LetTheRedeemedL 2 Replies Last reply Reply Quote 0
        • O Offline
          OliverCloasov @LetTheRedeemed
          last edited by

          @LetTheRedeemed I'm open to it

          1 Reply Last reply Reply Quote 0
          • O Offline
            OliverCloasov @Guest
            last edited by

            @sneedful Interesting, did he elaborate on the mechanism and the degree?

            ? 1 Reply Last reply Reply Quote 0
            • Z Offline
              zorba990 @LetTheRedeemed
              last edited by

              @LetTheRedeemed Wonder what would happen if I bubble hydrogen through ribose infused water?

              Found this on Amazon : https://www.amazon.com/RPI-2-Deoxy-D-Ribose-500-Grams/dp/B01N0X8O06

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              • LetTheRedeemedL Offline
                LetTheRedeemed @Guest
                last edited by

                @sneedful dangit. in that case it could be working on hair growth thru the estrogen function: increase water retention, ie bloodflow

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                • LetTheRedeemedL Offline
                  LetTheRedeemed
                  last edited by

                  Anybody recall Peat's quote on sugar helping hair growth? was he talking topical? I wonder what topical glucose + ATP + Progest E might do.

                  H 1 Reply Last reply Reply Quote 0
                  • B Offline
                    bot-mod
                    last edited by

                    This is so simple I could believe in it.

                    Thanks for sharing it.

                    LetTheRedeemedL 1 Reply Last reply Reply Quote 0
                    • H Offline
                      Hearthfire @LetTheRedeemed
                      last edited by

                      @LetTheRedeemed

                      I found this thread talking about it, from a podcast/conversation with Ray Peat and Danny Roddy titled
                      "Lost Conversations with Ray Peat #1: The Purpose of Hair, Luciferianism, and Obama as a CIA Creation​

                      https://raypeatforum.com/community/threads/did-ray-peat-just-recommended-topical-honey-for-hair.50151/

                      Looks like that episode has been nuked off the internet by the censors. Probably for that title and the discussion content.

                      LetTheRedeemedL 1 Reply Last reply Reply Quote 0
                      • LetTheRedeemedL Offline
                        LetTheRedeemed @Hearthfire
                        last edited by

                        @Hearthfire brooo you came thru king.

                        I'm thinking a topical spray of glucose + a pro-energy substance like t3/niacinamide/aspirin!

                        1 Reply Last reply Reply Quote 0
                        • LetTheRedeemedL Offline
                          LetTheRedeemed @bot-mod
                          last edited by

                          @ThinPicking right? Now I'm even more excited to try Ray's suggestion of topical glucose.

                          1 Reply Last reply Reply Quote 0
                          • LetTheRedeemedL Offline
                            LetTheRedeemed
                            last edited by

                            @Mauritio
                            You said this in the old rpf thread above:

                            Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                            I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                            With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                            Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                            MauritioM 1 Reply Last reply Reply Quote 0
                            • MauritioM Offline
                              Mauritio @LetTheRedeemed
                              last edited by

                              @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                              @Mauritio
                              You said this in the old rpf thread above:

                              Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                              I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                              With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                              Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                              It definitely helps . But I switched to using Apple juice because, it has sugar as well and because of the polyphenol content. Actually I dissolved a full capsule of swansons apple polyphenols in a bit of juice and applied it to my scalp . It really made a difference , but it was such a mess to apply that I stopped.

                              Dare to think.

                              My X:
                              x.com/Metabolicmonstr

                              LetTheRedeemedL 1 Reply Last reply Reply Quote 0
                              • LetTheRedeemedL Offline
                                LetTheRedeemed @Mauritio
                                last edited by

                                @Mauritio gotcha. Thanks for sharing

                                1 Reply Last reply Reply Quote 0
                                • W Offline
                                  wester130 @LetTheRedeemed
                                  last edited by

                                  @LetTheRedeemed

                                  a month ago someone mentioned topical ribose completely unconnected to this study though

                                  https://old.reddit.com/r/raypeat/comments/1dlavfd/baldness_is_insulin_resistance_metformin_is/

                                  LetTheRedeemedL 1 Reply Last reply Reply Quote 0
                                  • LetTheRedeemedL Offline
                                    LetTheRedeemed @wester130
                                    last edited by

                                    @wester130 nice, thanks for sharing

                                    1 Reply Last reply Reply Quote 0
                                    • LetTheRedeemedL Offline
                                      LetTheRedeemed
                                      last edited by

                                      @Amazoniac Yo brotha.

                                      Do you have any thoughts on d-ribose supplementation? Could it have negative repercussions?

                                      AmazoniacA 1 Reply Last reply Reply Quote 1
                                      • AmazoniacA Offline
                                        Amazoniac @LetTheRedeemed
                                        last edited by

                                        @LetTheRedeemed

                                        From what I can remember in posting about it on the Ray Peat Forum, supplementation is safe. In support:

                                        • Sub-chronic (13-week) oral toxicity study with d-ribose in Wistar rats
                                        LetTheRedeemedL 1 Reply Last reply Reply Quote 1
                                        • LetTheRedeemedL Offline
                                          LetTheRedeemed @Amazoniac
                                          last edited by

                                          @Amazoniac ah ok… thanks so much for the info

                                          1 Reply Last reply Reply Quote 0
                                          • LejebocaL Offline
                                            Lejeboca @LetTheRedeemed
                                            last edited by Lejeboca

                                            @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                                            EDIT: "it increases NO [nitric oxide is bad for metabolism] so according to danny roddy it is le bad." - sneedful
                                            Any references indicating this to be true or false would be appreciated.

                                            This review warns against high doses of D-ribose:
                                            https://www.spandidos-publications.com/10.3892/etm.2021.9927

                                            "In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means. D-ribose may glycosylate insulin to form ribosyl insulin, activate Caspase-9 and -3/-7, trigger transcription factor NF-κB and produce intracellular reactive oxygen species (ROS) that may cause cytotoxic damage to the surrounding tissues and cells, eventually leading to the manifestation of chronic complications (63)."

                                            So, I suppose, D-ribose may increase inducible NO (iNOS) by way of triggering NF-kappaB, which is a primary inflammatory response (see, e.g., pubmed here)

                                            Personally, i will avoid supplementing with D-ribose due to a possible NF-kappaB trigger, even not being a diabetic.

                                            Ben.B CiceroC 2 Replies Last reply Reply Quote 0

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