Random, interesting studies
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Vitamin A supplementation in third world countries drastically reduces mortality.
"Among children aged 12-71 months at baseline, mortality in control villages (75/10 231, 7·3 per 1000) was 49% greater than in those where supplements were given (53/10 919,4·9 per 1000) (p<0·05). "
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(86)91157-8/fulltext
(Mild)Vitamin A deficiency still affects almost a billion people
"In 2019, VAD and mVAD affected 333.95 million (95% CI = 253.00-433.74) and 556.13 million..."
https://pmc.ncbi.nlm.nih.gov/articles/PMC10416138/92% ofChildren with measles had Vitamin A deficiency. Giving them Vitamin A reduced their mortality by 50%!
https://pubmed.ncbi.nlm.nih.gov/2194128/From: "Endocrine Physiology" by Constance R. Martin, Ph.D. :
"Laboratory mammals maintained on Vitamin A-
deficient diets stop growing, acquire numerOuS epi·
the]ial cell and connective tissue disorders. and be·
come blind and sterile. ""However. retinol or a precursor is needed for
spermatogenesis, for the ability to sustain preg·
nancy, and for the formation of visual pigments. ""Vitamin A supports bone remodeling. In defi·
ciency states. the passageways for nerves and blood
vessels do not enlarge sufficiently. Infants deprived
of the vitamin have detective loolh formation_" -
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Vitex Agnus castus:
TLDR:
- very strong evidence on pro-progesterone effect
- strong evidence on anti-prolactin effect, esp. In high doses
- few studies on estrogen and testosterone, effects ranging from low antagonism to slight agonism in both
PROGESTERONE:
In this human study on women with hyperprolactinemia it increased progesterone by almost 4-fold ,while increasing estrogen 1.13 fold.
So there's a very strong increase in progesterone and a comparably insignificant increase in estrogen."...and eliminated deficits in luteal
progesterone synthesis (placebo: 1.99±0.65→2.34±0.59 ng/ml; verum: 2.46±0.70→9.69±6.34) in
the verum group. The changes were significant. All other examined hormonal parameters did not change with the exception of 17ß-estradiol which increased significantly in the luteal phase in patients receiving verum (placebo: 119.5±26.0 pg/ml→131.1±33.2; verum: 131.6±25.0 pg/ml→151.6±25)"PROLACTIN:
Here's a lot of info on it from the RPF ,with OP claiming it removed his premature ejaculation. Dosage seems to be important.
https://lowtoxinforum.com/threads/vitex-for-men.11538/
