Epitestosterone, premature balding, and "male PCOS"
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@risingfire said in Epitestosterone, premature balding, and "male PCOS":
@insufferable have you ever tried spironolactone? It's used for women with PCOS. It's much easier to acquire compared to epiT
I'm not familiar with it, what does it do?
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This is the study that measured testosterone, epitestosterone, and DHT in the hair follicles of balding guys.
https://www.jidonline.org/article/S0022-202X(15)41116-9/fulltext
Here's the result:
What stands out most to me is plain old testosterone. Bald men have a lot more testosterone in their hair follicles. But as you know, they don't have any more testosterone in their blood than non-balders, and don't display the good "results" of testosterone in the body any more than non-balders. Anecdotally, I think they display a lot less! And at least in premature balders ("Male PCOS"), the studies confirm this.
It makes me think of calcium and vitamin K2. Calcium is good in the bones and bad when it inappropriately gets into soft tissue. Vitamin K2 somehow keeps calcium in the bone and out of soft tissue.
Some unknown factor puts testosterone where it should be and keeps it out of where it shouldn't be - the hair follicle. (and perhaps other places?)
When that unknown factor is not functioning well, testosterone is less present where it should be and more present where it shouldn't be.
Another question is what function do hormones have in hair follicles? What would testosterone be doing in your hair? What good does it think it's doing up there haha? Seems to me that it shouldn't be there at all. So WHY does it show up there?
Also I'd like to know how and why DHT has the function of miniaturizing hair in the first place. How does it do that? (I don't agree with the alternative claim that DHT doesn't cause hair loss. It absolutely does. DHT directly miniaturizes hair follicles right away in lab tests. However I do agree with the claim that DHT is good for you and that "high DHT men" often have plenty of hair. Because it's the varying levels in the different tissues that matter.) So how and why does DHT miniaturize hair? What purpose is it fulfilling, or attempting to fulfill but going off course instead?
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@insufferable That study theorizes that epitestosterone converting to epiDHT is what prevents hair loss. EpiDHT takes the seat of DHT in the hair follicle, thus preventing DHT from getting in and doing its thing.
There are two more studies in this series, which don't have quite as nice and clear results. I'll post them soon.
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@insufferable it was designed as a potassium sparing drug for high blood pressure, edema, pcos, heart failure and excess aldosterone. If I remember correctly, it's an anti-androgen
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@insufferable this is quite interesting.
EpiT is 5AR inhibitor. I wonder how useful it would be in taking if it could be acquired. Is it known to inhibit hpg axis?
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@risingfire I would imagine not. Most pharmaceutical anti-androgens (at least those that block the androgen receptor itself - for example bicalutamide) actually increase levels of circulating androgens because the hypothalamus androgen receptors are also "blocked" and as such the hypothalamus "thinks" that there are no androgens in serum.
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@saturnuscv thank you
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Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.
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@Gaston do keep us updated on that. I want to try 7kDHEA but I don’t want to make anything worse.
My hair is not too bad at the moment but since stopping progesterone I have been shedding more than usual. I’m close to just giving up on exogenous steroids and thyroid+cholesterol+bloomaxxing because every time I introduce some kind to steroid it either greatly aggravates shedding (Pansterone) or makes me feel and look like shite (Cortinon)
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Thanks for those papers! 57% of those who are already bald by age 45 have metabolic syndrome compared to 14% of non-bald 43 year olds. That's an impressive result.
@Gaston said in Epitestosterone, premature balding, and "male PCOS":
Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.
Interesting! Where did you find that out? I couldn't find anything about it.
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https://www.degruyter.com/document/doi/10.1515/CCLM.2005.038/html
I came across it in one of Hans' articles.
https://testonation.com/2022/01/17/7-keto-dhea-what-you-need-to-know-fat-loss-thyroid-androgens-etc/
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@Gaston Awesome, thank you! That's the first place I've seen any mention of an epiT increase.
~12% testosterone decrease, ~80% epitestosterone increase.
I know nothing about 7-keto-DHEA. Do you have any idea why it would do that?
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@insufferable
I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting! -
@Gaston You might be on to something.
I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.it is not water soluble though.
"7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."
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I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.
Dare to think.
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The whole section under anti-andrigenic activity really doesnt sound good...
But if it is only locally in the scalp, it might be ok.
The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.
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This is how I attempted to dissolve the powder:
7-Keto-DHEA
300mg powder
1/2 oz. dropper bottle
~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
~80% ethanol
(~5% powder)
~300 drops
~1mg per dropIt didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.
When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol
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@Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.
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@insufferable and how to cure PCOS?
Inositol??
