Epitestosterone, premature balding, and "male PCOS"

Insr

Thanks for those papers! 57% of those who are already bald by age 45 have metabolic syndrome compared to 14% of non-bald 43 year olds. That's an impressive result.

@Gaston said in Epitestosterone, premature balding, and "male PCOS":

Supposedly you can increase epitestosterone by topically applying 7-keto-DHEA. I doubt applying it to the scalp would do anything, but if I can get the 7-keto-DHEA to dissolve, I'll put some on my scalp and on my navel/stomach and see what happens.

Interesting! Where did you find that out? I couldn't find anything about it.

Gaston

@insufferable

https://www.degruyter.com/document/doi/10.1515/CCLM.2005.038/html

I came across it in one of Hans' articles.

https://testonation.com/2022/01/17/7-keto-dhea-what-you-need-to-know-fat-loss-thyroid-androgens-etc/

Insr

@Gaston Awesome, thank you! That's the first place I've seen any mention of an epiT increase.

~12% testosterone decrease, ~80% epitestosterone increase.

I know nothing about 7-keto-DHEA. Do you have any idea why it would do that?

Gaston

@insufferable
I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting!

Mauritio

@Gaston You might be on to something.
I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.

it is not water soluble though.

"7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."

Mauritio

I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.

Mauritio

The whole section under anti-andrigenic activity really doesnt sound good...

But if it is only locally in the scalp, it might be ok.

The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.

Gaston

@Mauritio

This is how I attempted to dissolve the powder:

7-Keto-DHEA
300mg powder
1/2 oz. dropper bottle
~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
~80% ethanol
(~5% powder)
~300 drops
~1mg per drop

It didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.

When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol

saturnuscv

@Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.

wester130

@insufferable and how to cure PCOS?

Inositol??

wester130

@Gaston

it won't work topically??

Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
https://www.ncbi.nlm.nih.gov/pubmed/11300231

wester130

@saturnuscv I now think men could try licorice, vitex and spearmint and schisandra

https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/

testosterone is "bad" when it is out of control

wester130

@Insr

https://pubmed.ncbi.nlm.nih.gov/16462145/

licorice reduced dhea-s

stinging nettles reduced cortisol too

https://pmc.ncbi.nlm.nih.gov/articles/PMC8959287/