Epitestosterone, premature balding, and "male PCOS"
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@insufferable
I can't say that I understand the mechanism, no. But that's not going to stop me from recklessly experimenting! -
@Gaston You might be on to something.
I remember when taking 7ketoDHEA my hairloss was decreased. It is pretty safe to experiment with.it is not water soluble though.
"7 Keto DHEA (Dehydroepiandrosterone) is a white crystalline powder. It is very soluble in warm methanol, soluble in ethanol, and not soluble in water. Micronized so that 90% of particles are less than 20 μm."
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I am going to try to dissolve a few mg of 7ketoDHEA in alcohol and apply it to my scalp.
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The whole section under anti-andrigenic activity really doesnt sound good...
But if it is only locally in the scalp, it might be ok.
The difference of epitestosterone in the scalp between balding and non-balding fasthers is huge. Non-balding fathers have an almost 6 times lower Testosterone/ epitestosterone ratio in the scalp.
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This is how I attempted to dissolve the powder:
7-Keto-DHEA
300mg powder
1/2 oz. dropper bottle
~15% isopropyl myristate (I don't think this is necessary, but I had some left over from dissolving DHEA powder)
~80% ethanol
(~5% powder)
~300 drops
~1mg per dropIt didn't fully dissolve, but that's because there are excipients in the capsule like silicon dioxide and magnesium stearate. I don't think that there exists a commercially available source of pure 7-Keto-DHEA powder.
When I apply 10mg to my navel I get sleepy as heck, but that could also be because I'm laying down when I do it lol
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@Gaston it’s anti-cortisol and doesn’t supply a substrate to make estrogen so feeling sleepy is not unusual.
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@insufferable and how to cure PCOS?
Inositol??
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it won't work topically??
Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.
Sulcová J1, Hill M, Masek Z, Ceska R, Novácek A, Hampl R, Stárka L.
https://www.ncbi.nlm.nih.gov/pubmed/11300231 -
W wester130 referenced this topic on
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@saturnuscv I now think men could try licorice, vitex and spearmint and schisandra
https://pmc.ncbi.nlm.nih.gov/articles/PMC8140208/
testosterone is "bad" when it is out of control
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https://pubmed.ncbi.nlm.nih.gov/16462145/
licorice reduced dhea-s
stinging nettles reduced cortisol too
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