Epitestosterone, premature balding, and "male PCOS"
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This raises an interesting question of whether androstenedione might be a better "base" compound for a steroid cycle as it supplies a precursor for both test AND epitest, so it even though it raises the T:Epi ratio in a vacuum, compared to just being on test and having 0 EpiT it might be comparatively desirable.
The same source sells a DHEA ester and I wonder if that might be a similar situation...
Yes I think so, too.
Although it seems to depend a lot on downstream conversion and the enzymes that convert substrates into EpiT.
On my nail test you can see I have very androstenedione and high T but non existent EpiT, so downstream conversion seems to be an issue here. Not sure how to address that.If someone still wants to test out androstenedione, here's a video using binaural beats that simulates it.
Youtube Video -
Androstenedione was more effective than testosterone in this study .
Post in thread 'Androsterone - Androgenic Neurosteroid Required For Male Sexual Behavior' https://lowtoxinforum.com/threads/androsterone-androgenic-neurosteroid-required-for-male-sexual-behavior.12608/post-984465
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@Mauritio Apparently androstenedione can't be esterified
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@jimmynelson based on all this - would telmisartan be the best drug?
it acts like metformin in a unique way to control insulin resistance but also helps blood pressure and reduces aldosterone
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@wester130 I'm not sure insulin resistance or aldosterone factor in much here. can you elaborate on what you mean?
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@jimmynelson pcos phenotype being driven by insulin resistance and SHBG
telmisartan can help insuling resistance
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the benefits are sometimes better than dhea
https://www.rthm.com/resources/blogs/7-keto-dhea-supplement-guide
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B BioEclectic referenced this topic
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Nettle root may be more interesting than anything els
1 - it reduces aromatase enzyme
2 - binds to shbg, so testosterone won't, therefore allowing more testosterone
3 - may even reduce DHT
so it's a very interesting mechanism, even though it raises testosterone it balances the estrogen testosterone ratio
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Has anyone tried well cooked mushrooms? There are many people reporting that it shifts the test/e2 ratio incredibly favorably, (better even than AIs). I hate to keep spamming Hans’ substack, but he’s run bloodwork pre-post mushroom experiments, and shown test/e2 rations above 20:1, (might have been 30:1 I don’t remember).
Myself personally, (no bloodwork) but since I’ve added 3oz of well cooked mushrooms to each meal, I’ve seen nothing but improvement, (less puffy, zero constipation, reduction in inflammation, better mood etc).
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