Peaty uncoupler vs. Ozempic who wins ? New study.
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@Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:
BAM down regulated SCD1 by almost 900-fold ! SCD1 concerts saturated fats into unsaturated fats and is implicated in many chronic diseases.
"...severe downregulation of sterol regulatory element‐binding transcription factor 1 (Srebf1 ; 490‐fold downregulated), carbohydrate‐responsive element‐binding protein (Mlxlpl ; 99‐fold downregulated), fatty acid synthase (Fasn ; 89‐fold downregulated), stearoyl‐CoA desaturase (Scd1 ; 898‐fold downregulated), adipose triglyceride lipase (Pnpla2 ; undetected in BAM15), and peroxisome proliferator‐activated receptor gamma (Pparg ; undetected in BAM15)”
I think this above part is very interesting. These down regulated factors all point to BAM lowering lipogenesis. It might even all be downstream from PPARg .
Fireinabottle writes about it here . Animals that lack PPARg remain insulin sensitive on a high PUFA diet and gain less weight. This happens because PPARg increased PDK4 which lowers pyruvate dehydrogenase. So lowering it will increase pyruvate dehydrogenase and enable you to burn sugar better.
In the study above on BAM15, PPARg was undetectable.
