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    Peaty uncoupler vs. Ozempic who wins ? New study.

    Literature Review
    bam15 semaglutide ocempic
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    • MauritioM
      Mauritio
      last edited by

      Science is slowly getting more peaty.
      Combination of a thyroid receptor b agonist with BAM15 for fatty liver, showed superior results than each on their own.

      https://pubmed.ncbi.nlm.nih.gov/39152636/

      Dare to think.

      My X:
      x.com/Metabolicmonstr

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      • ?
        A Former User @Mauritio
        last edited by A Former User

        @Mauritio post ur before and after too

        1 Reply Last reply Reply Quote 0
        • ?
          A Former User @alfredoolivas
          last edited by

          @alfredoolivas lol they made their Chinese peptide company sound like sigma Aldrich

          1 Reply Last reply Reply Quote 0
          • alfredoolivasA
            alfredoolivas @Mauritio
            last edited by

            @Mauritio updates on the BAM 15?

            MauritioM 1 Reply Last reply Reply Quote 0
            • MauritioM
              Mauritio @alfredoolivas
              last edited by

              @alfredoolivas The other 2 guys dropped out, so I haven't ordered 😕

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              alfredoolivasA 1 Reply Last reply Reply Quote 0
              • alfredoolivasA
                alfredoolivas @Mauritio
                last edited by

                @Mauritio 18e9c33a-d69b-4d8c-a627-2fb3bb93e38b-image.png

                They now sell it as 60 50mg capsules, but it is still quite expensive - 188 Euro including shipping.

                I used their service recently, my package took 10 days to arrive from when I first ordered and it reshiped from the netherlands so no customs issue. Highly reccomend them and their sales agent Tansy

                MauritioM 2 Replies Last reply Reply Quote 0
                • MauritioM
                  Mauritio @alfredoolivas
                  last edited by

                  @alfredoolivas nice thanks for the update.
                  I might actually do this.

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • MauritioM
                    Mauritio @alfredoolivas
                    last edited by

                    @alfredoolivas I ordered BAM15 a few days ago and if the tracking info is correct , it will arrive tomorrow already.

                    Not sure if I'll have time to try it right away since I'm still running another experiment, but maybe over the weekend I'll try a low dose.

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

                    alfredoolivasA 1 Reply Last reply Reply Quote 0
                    • alfredoolivasA
                      alfredoolivas @Mauritio
                      last edited by

                      @Mauritio yeah it’s a crazy shipping line they have running.

                      Are you referring to the DNP microdose? Amazing experimentation, may I ask what inspired you to pick 2mg as a dose or where I can find an explanation you previously gave?

                      MauritioM 1 Reply Last reply Reply Quote 0
                      • MauritioM
                        Mauritio @alfredoolivas
                        last edited by Mauritio

                        @alfredoolivas Yes, you can find more on my X. Search for "DNP" on my site or look at my latest post on DNP in which I quoted a few other posts on low dose DNP (including the relevant studies). And there's more studies on microdose DNP that I haven't postet yet. One study shows reversal of ALS phenotype in mice for example.

                        I suspect that I've developed tolerance to the 2mg dose. So I'll probably increase the dose to 4mg and see if the benefits reappear.

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        1 Reply Last reply Reply Quote 0
                        • KilgoreK
                          Kilgore
                          last edited by

                          Interesting thread @onliest

                          1 Reply Last reply Reply Quote 0
                          • MauritioM
                            Mauritio
                            last edited by

                            I received my BAM15 today (finally).
                            If someone wants to purchase half of it, let me know.

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            1 Reply Last reply Reply Quote 0
                            • MauritioM
                              Mauritio
                              last edited by Mauritio

                              Here BAM15 alleviated atherosclerosis by inhibiting the NLRP3 inflammosome.
                              The dosage was only 30mg (HED), so it seems low doses have benefits as well.
                              This was subcutaneous injectiom so you have to factor that in

                              "BAM15 reduced atherosclerotic plaque formation, lipid deposition, and inflammation, and diminished mtROS expression and ox-mtDNA content in the AS mouse models. In both in vivo and in vitro experiments, BAM15 markedly inhibited the activation of the NLRP3 inflammasome, leading to reduced pyroptosis in endothelial cells. "
                              https://pubmed.ncbi.nlm.nih.gov/40393254/

                              Here, BAM15 and a Trb agonist are more effective for treating fatty liver than each on their own. So combining BAM with sobetirome or just T3 should be good combo for the liver .
                              https://pubmed.ncbi.nlm.nih.gov/39152636/

                              Dare to think.

                              My X:
                              x.com/Metabolicmonstr

                              1 Reply Last reply Reply Quote 0
                              • MauritioM
                                Mauritio @Mauritio
                                last edited by Mauritio

                                @Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:

                                BAM down regulated SCD1 by almost 900-fold ! SCD1 concerts saturated fats into unsaturated fats and is implicated in many chronic diseases.

                                "...severe downregulation of sterol regulatory element‐binding transcription factor 1 (Srebf1 ; 490‐fold downregulated), carbohydrate‐responsive element‐binding protein (Mlxlpl ; 99‐fold downregulated), fatty acid synthase (Fasn ; 89‐fold downregulated), stearoyl‐CoA desaturase (Scd1 ; 898‐fold downregulated), adipose triglyceride lipase (Pnpla2 ; undetected in BAM15), and peroxisome proliferator‐activated receptor gamma (Pparg ; undetected in BAM15)”

                                I think this above part is very interesting. These down regulated factors all point to BAM lowering lipogenesis. It might even all be downstream from PPARg .
                                Fireinabottle writes about it here . Animals that lack PPARg remain insulin sensitive on a high PUFA diet and gain less weight. This happens because PPARg increased PDK4 which lowers pyruvate dehydrogenase. So lowering it will increase pyruvate dehydrogenase and enable you to burn sugar better.
                                In the study above on BAM15, PPARg was undetectable.

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                1 Reply Last reply Reply Quote 1
                                • MauritioM
                                  Mauritio
                                  last edited by Mauritio

                                  I've seen people dose BAM15 several times a day due to its short half life, but this might not be necessary.
                                  Since it's fat soluble, it stays active inside the mitochondria for a longer period of time.

                                  1000016410.jpg

                                  On its safety:
                                  1000016411.jpg

                                  https://pmc.ncbi.nlm.nih.gov/articles/PMC7338798/#emmm202012088-fig-0005ev

                                  Dare to think.

                                  My X:
                                  x.com/Metabolicmonstr

                                  alfredoolivasA 1 Reply Last reply Reply Quote 1
                                  • alfredoolivasA
                                    alfredoolivas @Mauritio
                                    last edited by

                                    @Mauritio I wish the intracellular half life of substances was studied more

                                    1 Reply Last reply Reply Quote 0
                                    • MauritioM
                                      Mauritio
                                      last edited by Mauritio

                                      I have tried BAM15 at a dose of 25mg for 1 week.

                                      I have lost about 600g in weight and my strength has increased. I was stuck at 8 pull ups for a few months and on my last day of taking it I increased the dose to 35mg and I was able to do 9 pull ups.
                                      If my observation holds true, and there is some evidence for that in the studies I posted, than this will become VERY popular amongst bodybuilders. A safer version of DNP where you loose weight and maybe even increase strength ?!
                                      The first 4-5 days I had a lot of bile dumps, what seems to be candida. I have noticed the same with DNP. Maybe uncoupling somehow helps the liver/ gallbladder somehow to excrete fungi.
                                      I also noticed from day 1 that I felt warmer and my hands were slightly sweaty. Although measured ear temp didn't change.
                                      I have stopped after a week because insomnia seems to have creeped up on me, but I'm not sure at all if it's even related because it's still there after I stopped.

                                      Overall those results are quite amazing given that a normal dose seems to be around 200-400mg and I noticed all of this from 25-35 mg.

                                      Dare to think.

                                      My X:
                                      x.com/Metabolicmonstr

                                      C 1 Reply Last reply Reply Quote 0
                                      • C
                                        CrumblingCookie @Mauritio
                                        last edited by CrumblingCookie

                                        @Mauritio
                                        To me as an outsider those changes may be subtle fluctuations.
                                        Wrt to the insomnia, could it be that your increased metabolism has depleted in some essential nutrient factor? Potassium or something of the wider B-family? Choline perhaps in the face of your reported biliary losses and what felt like increased liver turnover?
                                        We need you to push on and report wrt to a consistent and sustainable trend over the short and medium-term : ).

                                        MauritioM 1 Reply Last reply Reply Quote 0
                                        • MauritioM
                                          Mauritio @CrumblingCookie
                                          last edited by

                                          @CrumblingCookie I don't think so as the weight loss remaind after stopping. It might not sound like much but 600g per week is 2,4kg a month , that's pretty decent without trying hard.

                                          That could be, I do eat like 6 eggs a week so I should be getting enough choline. But maybe the b vitamins are the issue or insomnia isn't related to BAM at all.

                                          I'll maybe try 50mg over the weekend. i could also see myself using it weekly for the weight and liver benefits just to make if easier to maintain weight or eat more without gaining.
                                          There is also an androgenic feeling to it.

                                          If you or someone else wants to try it, im willing to sell half of it to bring the cost down .

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          C 1 Reply Last reply Reply Quote 0
                                          • C
                                            CrumblingCookie @Mauritio
                                            last edited by CrumblingCookie

                                            That could be, I do eat like 6 eggs a week

                                            These are rookie numbers. You've got to pump these numbers up! You may need those 6 eggs = c. 900mg choline not per week but per every day! Go Go egg pudding!

                                            Feeling initial benefits from substances until soon hitting a wall is easy. The art lies in figuring out and overcoming the latter. I, however, have more imminent priorities than upping metabolism rn.

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