Posts made by Mauritio

@cs3000 Most people cant see a good candidate when hes right in front of them. The world isnt going to change until guys like him can get into office.

I think Haidut mentioned that someone familiar with Peat was in his camp...

I have purchased two new laptops.

1. Lenovo Laptop | 17,3" | Intel 8505 | 5 x 4.40 GHz
Radiation: 1-6 uT, mostly between 1.5-2.5 uT

2. HP 17,3" Full-HD IPS Notebook AMD Ryzen 3 5300U @3,8GHz
Radiation: 0,2-1,5 uT, mostly between 0,2-0.7 uT

So you can see the Lenovo one emits at least 3-4 times more radiation, for no obvious reason.
I will return the first one.

Radidation seems to vary a lot from model to model. Only one way to find out: to buy it.
Acutally its surprising that I could not find a comprehensive list of laptop models and their radiation levels anywhere on the internet. So im posting this here to help others.

The HP one is still higher than my chromebook, but it is a lot larger and has more power.
With my chromebook I had a similar situation, I bought two and the first one had a radiation several times higher than my current one- Go figure...

@Purp1eOne Have you tried those?

Does it make sense to use them if you never use your laptop on your lap ? Im not sure- It seems to shield the radiation going downwards into the ground.
But Im using my laptop on a desk so im more concerned about the radiation that comes towards me and I dont see how this is helping there. Maybe Im missing something.

I already tried it and it seems to be work fine with MCT oil.

@Kvothe because of the SFA esters.. I assume the FA Stands for fatty acid.

Btw today was my first day taking rapamycin myself.

I started with 1mg.
And I notice that I feel very energetic. Normally I feel quite tired after a day of work but today I feel fit, especially mentally. Less brainfog. Also my mood is better.

I also notice that I'm calmer and more patient with people.

It's all very early but so far so good.

Rapamycin is anti-MUFA and anti-cancer.

I suspect that a significant part of rapamycins anti aging effects are similar to having a low PUFA intake. Since rapamycin mostly works through lowering excessive inflammation, which is largely caused by PUFA consumption.

In this in vitro study the authors showed a that rapamycin inhibited SCD1 via mTOR inhibition, which lead to a decrease in breast cancer size.

"In all three cell lines, we found that rapamycin significantly decreased polysome-associated mRNA for stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzyme in monounsaturated fatty acid synthesis. Activators of mTOR increased SCD1 protein expression, while rapamycin, LY294002 and BEZ235 decreased SCD1 protein expression. "

Also, simply increasing MUFA via SCD1 was enough to cause breast cancer growth, while lowering MUFA had the opposite effect.

"Furthermore, SCD1 siRNA knockdown inhibited breast cancer cell growth, while over-expression increased growth. "
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965451/

This is only in vitro, so take it with a grain of salt. But I think it coherently outlines a logical mechanism of action . Plus: in several other studies SCD1 has been down to be pro-cancer (and other diseases) and rapamycin has been shown to be anti-cancer. Btw this is "only" increasing MUFA and it already has such terrible effect on the organism, now imagine what increasing PUFA would do...
https://www.cell.com/trends/cancer/fulltext/S2405-8033(23)00032-8

@Milk-Destroyer
On this thread we talk a little about possible diets and scenarios.
It's not just fruit, ice cream or potatoes are also relatively low protein/methionine.

Can I dilute SFA esters and anhydrol with MCT OIL? I want to make a less potent version of panquinone. Can I dilute it with MCT? Not sure because of anhydrol.

@Dibodibo they go out of their way to increase mTOR with frequent high protein meals.

Inhibiting mTOR via protein restriction or rapamycin has been shown to retard aging and increase life span by 25-40% in animal models.

Another thing about that study is that they used vitamin E acetate.
There have been several studies showing vitamin E acetate as less effective or even harmful compared to vitamin E succinate.

In this case the succinate form decreases liver carcinoma by 77% and acetate actually increased it.
https://raypeatforum.com/community/threads/vitamin-e-succinate-very-effective-against-liver-carcinoma-acetate-form-increases-it.35475/

Another case: 650% lower tumor volume with vitamin E succinate and no result from acetate.
https://raypeatforum.com/community/threads/vitamin-e-succinate-decreases-melanoma-size-by-650-in-vivo.39088/

So I'm wondering how effective Vitamin E succinate would have been for life extension?!

(BTW can someone tell these people that I'm banned on the RPF I still see people asking me questions in several threads)

@DavidPS wow, 40% increase in median life span in male mice is pretty good!
There must be something that benefits male mice more than female mice about vitamin E.

It might be that vitamin E could at least partially substitute for selegiline. Since they're both ameliorating oxidative stress. I think there's a lot to the free radical theory of aging otherwise substances like selegiline, ergothioneine or vitamin E wouldn't be so successful in retarding death.
The oxidative stress is mostly downstream from PUFA consumption IMO, that's Why peat said there would be little use for vitamin E, if PUFA consumption was low or zero.
The above book recommendation comes to mind again.

Vitamin E seems to rescue the sickest individual, hence the increase in median life span, but has less drastic effect on maximum life span. In other words it prevents premature death first and foremost.
Which is similar to what selegiline is doing.
I talked about this on the forbidden forum in this post Post in thread 'Selegiline Experiences' https://raypeatforum.com/community/threads/selegiline-experiences.18419/post-903080

Btw selegiline has good safety record and has been used in humans for decades. So I don't see any issues with weekly dosing.

@Purp1eOne I agree .
It's very hard to predict.
Currently i use a Chromebook. I ordered one right before that but it had such a high EMF reading on my meter that I had to return it. It also gave me symptoms IIRC. Then I bought my current Chromebook and it had like 10 times less EMF radiation for whatever reason... they're the same size.

So I ordered a new Lenovo laptop today since I read that EMF sensitive people often do well with newer models of Lenovo. But if the EMF values are too high I'll simply return it and get another one.

Experimentation ...

@DavidPS Thanks for sharing that combination study !
Around a 30% increase in life span. Not bad.
This study shows that stacking anti-aging substances (with different mechanisms) lead to an additive effect in life extension. The authors also cite more studies where that was the case in the "discussion" section.

In this study:
mTOR is covered by rapamycin.
The ERK pathway by trametinib.

Now I'm wondering what would happen if you combine selegiline or ergothioneine with rapamycin since they both have different MoA than rapamycin,targeting oxidative stress mainly.

@0uro itchiness is associated with inflammatory mediators like histamine or NO. So not a good.
But not necessarily a sign of Heavy metals.

@Mr-X i have something to report about Amecke orange / mandarinensaft.
It seems to have a skin and hair softening effect on me. The closest thing I can describe it to is a mix of vitamin D and pregnenolone. In terms of skin and hair effects. It gives me that "glow" effect.

First I thought it was a coincidence but over the last 3-4 days I tried it out out more often. And especially today I became sure of it.
It doesn't last extremely long, maybe 4-6h but then again I don't drink large quantities of the juice, maybe 1 or 2 glasses a day.

I also suspect that it makes my muscles look fuller and gives me energy, but I'm less sure about that.
There seems to be a hormone like action going on. I know that the polyphenols in fruits have hormone like actions and/or increase steroidogenic enzymes. I made a big thread about that on the RPF about elderberries polyphenols.

I'm not sure which part of the juice it is. But i suspect it is the mandarin part, since I never got an effect like that from any OJ I drank.

Im currently trying to find out what causes less EMF exposure? A laptop or a computer with a monitor.
The computer monitor probably has more EMF, but stands further away. I also dont get any symptoms from my TV. So maybe the monitor would be better.

Im currently using a lenovo chromebook, which is fairly low EMF, but the screen is simly too small.

Any experience ?

@Mr-X ok thanks . I've never even heard of that brand. But I'll take a look.

Amecke citrus Mandarin /orange juice is good as well. It's 30% Mandarin juice and those are pretty close to clementines.

If one wants to replace rapamycin haiduts lipodd might be a good alternative.

This study compared C15 to rapamycin and other compounds and found the biggest overlap on terms of anti-aging activity between C15 and rapamycin. C15 also inhibits mTOR.

"At their optimal doses, C15:0 shared numerous clinically relevant activities with rapamycin and metformin."
https://www.mdpi.com/2072-6643/15/21/4607

What's interesting as well is it's ability to be incorporated into cell membranes . Theres a clear tendency amongst animals: the more saturated the cell membranes, the longer the animals live.

(Book recommendation on this topic: Human longevity by Valentine and Valentine)

@evan-hinkle congrats on the success with b1.
Such a shame that rapa stopped working.
I'll try it soon too.