Posts made by Mauritio

This study shows that the type of carbohdyrate matters: sucrose is superior to starch, in terms of FGF21.

Eventhough the 2 experimental diets have on paper the same ratio of carbs, protein and fat, they have very different outcomes. The group that had a higher sucrose ratio in their carbs had a higher metabolism, much higher UCP and FGF21, lower triglycerides, etc...

This makes the results of the above mentioned human study even more impressive, since they ate a lot of starch but managed to increase FGF21 by 800%. It probably would have been even more, if they had eaten more sucrose and less starch.

• https://www.sciencedirect.com/science/article/pii/S0955286317301948?via%3Dihub#bb0110

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

@DavidPS
Sorry for the confusion as well.
The 800% increase in FGF21 was actually from the high carb diet. And as the person in the video you posted explained, they ate pasta, bread, corn and drank juices.

Im going to look into that study more, mainly because it is human and the increase is so high.
Now compare that to the low protein study (also in humans) and they only had a 150% increase after 4 weeks.

So it seems high carb is more important than low protein!

This is actually an excellent study. Aswers a lot of questions.

Again: high carb, seems more important than low protein. And low fat (PUFA) is important, too.

They used the following diets:
High carb: (80 E% carbohydrate, 11 E% protein, 9 E% fat)
High fat: (10 E% carbohydrate, 12 E% protein, 78 E% fat)
Control: (62 E% carbohydrates, 14 E% protein, 24 E% fat)

The dfference in FGF21 between high carb and control is massive, yet the control group also ate a lot of carbs and the protein was almost the same, so the only factor that strongly differs is the fat content, which is 2,5 times higher in the control diet.
Leading me to believe that this is crucial as well: high carb AND low fat. If it was only the carbs than the control diet should have outperformed the high fat diet ,which it didn't.

This underlines what Peat said for a long time that: a high carb, low/medium protein, low fat is very healthy.
I think you can go higher on protein if it is gelatin. And maybe higher on fat if it is SFA ? Im going to look into the realtionship between SFA and FGF21.

Another thing we should look into is all the protein restriction animal studies.
Are they really low protein studies ? Or high carb,low protein?What is the diet of the control groups in these studies?

Btw fasting is not effective in humand to boost FGF21: "...an increase in circulating FGF21 concentration is not detected until after 7–10 days of starvation in humans ..."

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220397/

@DavidPS
Sorry for the confusion as well.
The 800% increase in FGF21 was actually from the high carb diet. And as the person in the video you posted explained, they ate pasta, bread, corn and drank juices.

Im going to look into that study more, mainly because it is a human study and the increase was so high.
Now compare that to the low protein study (also in humans) and they only had a 150% increase after 4 weeks.

So it seems high carb is more important than low protein!

This is 2,6 dihydroxybenzoic acid :
<img src="https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/structures/196/724/160fee6b-8d74-427c-b54d-738933a5fa1c/800/160fee6b-8d74-427c-b54d-738933a5fa1c.png" alt="2,6-Dihydroxybenzoesäure 98%"/>

this is aspirin (acetyl salicylic acid):

The structural similarity becomes even more obvious when you look at salicylic acid, which is where aspirins effects come and is called 2-hydroxybenzoic acid:

<img<img

What is not clear to me is why the 2,6 dihydroxybenzoic acid is more effective without the vitamins, since they should only enhance the anti-cancer effect...

Thanks.
So the way I heard it, the following order emerges in terms of effectiveness, from high to low (mind you, the experiments are still ongoing):

1. 2,6 dihydroxybenzoic acid
2. 2,6 dihydroxybenzoic acid + B Vitamins
3. Aspirin + B Vitamins
4. Aspirin + 2,6 dihydroxybenzoic acid

1. I could never tolerate gelatin or glycine powder, but I can use slices of gelatin that are meant for baking.

2. I notice that apple polyphenols are synergistic with gelatin in terms of hair health. Not sure why but I notice that there is less hair loss when I combine them then when I take each of them separately.

3. A Homeopathic remedy called "Schüssler Salze", number 10 for liver and gallbladder. Definitely helps with stuck bile. I had issues with that for 6 months , after less than a week of taking it, the issues were a lot less . Still taking 1 per day as maintenance.

4. The acupressure point for liver gallbladder on the head of your fibula also helps with stuck bile and bowel movements, at least in my experience. Not a game changer ,but a little boost.

5. Small amounts of oat bran reliably help with BMs.

This shall be a collection of random, little things that helped me. Things that I haven't made a thread on, but are worth mentioning.

In no particular order or importance.

@DavidPS said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

My diet includes a large amount of glycine. Yesterday I entered my food into cronometer.com and my methionine:glycine ratio was about 1:10. I suspect that the effect from low methionine and the effect of high glycine are additive. From 2023:

Glycine and aging: Evidence and mechanisms

Highlights
• The simple amino acid glycine extends lifespan in worms, mice, and rats.

• Glycine also improves aspects of health in mammalian models of age-related disease.

• Glycine is the acceptor for GNMT, an enzyme responsible for methionine clearance.

• GNMT also converts glycine to sarcosine, an autophagy-inducing metabolite.

• Glycine may prolong life by inducing autophagy and mimicking methionine restriction.

Thanks
Wasn't the increase in longevity from glycine "only" about 8%? That's quite far from MR which achieved between 30-40%. So this suggests that glycine isn't enough to mimic MR.

@Ismail said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

Anyone watched Georgi’s interview on the strong sistas channel? He goes into discussing his study in quite some depth:

https://youtu.be/skeXyC1_MVA?si=_Q4P6CPHqrW9ymm2

Thanks for posting , I was going to ask where he talked about it.
I'll watch it soon, but does he mention how he came on with using dihydrobenzoic acid ?
IIRC his methylene blue product contains benzoic acid ...

@DavidPS said in A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma:

@Mauritio - Yes, it appears that he is not interested in patenting.

He selected the least expensive form of B1 to make his invention accessible to as many people as possible.

I am a registered patent attorney. I think he could obtain a patent based on the limited facts that I have. He solved a long-standing problem; that is a strong indication of patentability.

Ok in that case ,you know more about this than me.
Would be an interesting thing to ask him if he has any intentions on patenting it.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

Concentric exercise, in this case, treadmill uphill walk variations, increase FGF21 by 66% in 2 weeks in humans
https://pubmed.ncbi.nlm.nih.gov/22701542/

Interestingly upstairs walking, a form a concentric exercise, has by far the highest calorie expenditure amongst all the sports tested.

https://x.com/T3MaxxiAlt/status/1759793246769987880

BTW if anyone finds any other ways to boost FGF22 let me know. I feel like boosting FGF22 is a better way key to get the benefits of MR without having to eat in a too restricted way.
I think methionine restriction boosts FGF22 something like 800% and I have yet to find anything else that comes even close to that .

It might be that he is waiting for a publication, but Im not sure if he really wants to patent this treatment. Did he say that anywhere ?
Plus, I'm not sure if you can patent a combination of basic vitamins. Normally you would have to change something structurally on the molecules ...

All 3 mice are now fully cured and cancer-free.

I dont know why Georgi isn't making a bigger deal out of this. Because this is a big deal.

https://x.com/haidut/status/1758122576411279659

https://x.com/haidut/status/1777337478636007790

@wrl said in Ergothioneine - amino acid for life extension.:

Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?

https://www.liebertpub.com/doi/full/10.1089/ars.2021.0043

Good one.

It also seems to have cosmetic benefits .

"ET accumulates in skin cells and not only prevents oxidative damage but also facilitates DNA repair in UV-irradiated cells (80). For these reasons, ET has been included as an ingredient in several skin care products and cosmetics."

I took my first tablet yesterday.

It increases muscle fullness and I am feeling more androgenic. I think it is good for liver health. Had some bile dumps and felt a sense of relief after.

I am currently adjusting my thyroid dosage and everbody who did that before knows that can be a pain in the ass and you might have to go through a few days of suboptimal thyroid function. Ergothioneine definitely helped with that and relieved the low mood and lethargy associated with hypothyroidism. It also made me more active during the day, but sleep was very refreshing.
Verbal fluency seems increased.
The only downside is hair loss is a bit increased. But not strongly.

I can only encourage people to try it. Given its long half life it might be taken only 1 or twice a week since the body accumulates it similarly to the fat soluble vitamins.

@Peatly said in Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%:

@Mauritio Thank you.

I just found this quote from the mega master newsletter

"Recently, the polyunsaturated oils have been identified as the main thing in cells that radiation interacts with, to cause cellular damage. Vitamin E, taken internally or even applied to the skin, has been found to reduce the damage produced by exposure to ultraviolet radiation, which is logical, since it interrupts the chain reactions of toxic free-radicals produced when unsaturated oils are oxidized by radiation or other injury. Aspirin has been found to have a similar effect in reducing the harmful effects which develop in the skin after sunlight overexposure. Coconut oil has been used for generations in “ suntan lotions, ” and whether it is absorbed through the skin or eaten as a food, it clearly has a protective antioxidant function. Carotene seems to work with vitamin E in the skin to reduce injury by ultraviolet radiation. Caffeine also has shown a protective action against radiation, but its mechanism of action isnʼt clearly understood." Townsend Letter for Doctors & Patients, June 1996, Page 83 – 85

Dr. Peat also said he stopped burning in the sun after supplementing vitamin D, getting lots of milk and limiting PUFA.

Good one.

@Peatly said in Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%:

UV Radiation Induces Vitamin A Deficiency in Skin

Peat has a very old newsletter where he says that UV rays cause a film of free radicals on hair (and skin) that can persist for a few hours ,even after leaving the sun. Just a few seconds of red light will neutralize the free radicals.

Thanks for mentioning. I forgot about taking it. It made me kind of wired but tired after a while ,but I did enjoy it. And might try it again.

ERGO can protect against social defeat.

"...ergothioneine prior to and during the SDS (social defeat stress) paradigm had a preventative effect on SDS-induced depressive behaviors, such as social avoidance and depression-like sleep abnormalities, particularly those of rapid eye movement sleep."

Not only that, I already mentioned that some gut bacteria can synthesize ergothioneine. One of them is L. Reuteri. It can increase testosterone dramatically and is anti-inflammatory. Well, another benefit can be added to the list now! Hans made an interesting video on it.

https://www.youtube.com/watch?v=UuOxSrFonqs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256047/