Posts made by NNight

The dehydration treatment of epilepsy

Note: this was for epileptic children.

The decrease in the cytoplasmic kosmotropic osmolytes gradually transforms the structured water into unstructured water, which eventually causes a reduction in the order-information degree of the cellular thermodynamic-energy system, which upon reaching the maximum tolerable entropy, causes the cell a “near-death state”.

Measures that transform unstructured water into structured water, such as peritumoral hyperosmolality and increased intracellular kosmotropic osmolytes, and strategies that increase mitochondrial oxidative phosphorylation may restore physiological and cellular bioenergetics. The restoration of these metabolic parameters will provide the necessary information to reestablish order, organization, and compartmentalization that can stop neoplastic cells proliferation, promote differentiation, and restore cellular metabolic harmony.

Research efforts have suggested that the promotion of hyperosmolarity can be used as a form of treatment. Hyperosmolarity increases EZ water inside the cell, which in turn promotes apoptosis. This approach has a minimal effect on neighboring healthy cells, suggesting this treatment as a possible option for cancer. This treatment would function by restoring the structured water with the appropriate levels of EZ zones back into the cell. By doing so, the cell returns to its normal state of order and organization, which enables the cell to continue its normal metabolic course which includes reestablishing apoptosis.

Structured Water and Cancer: Orthomolecular Hydration Therapy

@ThinPicking thanks, that's kind of you

Thyroid and water homeostasis

The connections between water homeostasis, hyperosmolarity and the thyroid system are listed below:

• There exist theoretical arguments allowing us to hypothesize that hyperosmolarity, induced by water restriction for example, could facilitate the synthesis of thyroid hormones while potentially lowering the requirement for TSH stimulation.
• Rats (with an animal model of hypothyroidism) put under water restriction got an increase in their T3 levels, bringing them almost back to the control group’s levels.
• It was found that, in rabbits, vasopressin itself seems to play a role similar to TSH regarding thyroid hormone synthesis.
• Two studies on rats found that water restriction or deuterium depleted water (which might be interpreted by the body as water restriction) tend to lower TSH levels.
• Finally, bile acids could be related both to the TSH and metabolic rate of tissues involved in thermogenesis, but are also related to water homeostasis as the bile acid TGR5 receptor (along with the FXR transcription factor) is involved in kidneys’ function. From this data, we can hypothesize that a TSH decrease itself could boost T3 systemic levels as it might increase bile acids synthesis and thus peripheral deiodinase enzymes.

Thus, water restriction (or deuterium depletion) could lead to a TSH decrease while keeping thyroid hormones levels maintained or increased. The TSH decrease could be explained by an increase in vasopressin, which could play the role of a TSH surrogate and stimulate bile acids synthesis and thus the conversion of T4 to T3 in peripheral tissues.
Another explanation could be that hyperosmolarity itself, by activating the NFAT5 transcription factor which would upregulate the uptake of inositol by the thyroid, or activating the CREB3L1 transcription factor, would increase the sensitivity of the thyroid gland to TSH and optimize thyroid hormones output.
Upping intake of inositol, selenium and intermittently restricting water intake to achieve hyperosmolarity may improve the function of the thyroid system.

Pathology of structured water and associated cations in cells (the tissue damage syndrome) and its medical treatment

Also, vasopressin (antidiuretic hormone) might be helpful because it could shuttle potassium in the cells:

Within the 24 hour period after ADH injection, about 300~Eq of potassium were retained by each animal. Since serum potassium concentration did not change significantly, the bulk of retained potassium must have entered compartments other than the extracellular space. Since total renal potassium content in male Wistar rats of comparable body weight is about 120~Eq (unpublished observation), any increase in renal potassium content would contribute only slightly to the compartmentalization of the retained potassium. Therefore, the bulk of the retained potassium must have entered cells of extrarenal tissues. However, this argumentation demands further experimental proof.

ADH-induced potassium retention in rats with genetic diabetes insipidus

Could the consumption of high potassium foods, low salt and low water (increased antidiuretic hormone but without too much water retention) be a good way to improve cellular health?

@LetTheRedeemed
What is a diet?

What we should collectively do is discuss the best arguments of the adverse party, this is rarely done. The question is: is a "sustainable" keto diet possible, or are there better keto diets than others? Moore's specific case is of no utility here. Same for what keto influencers think.

Copy-paste of a post I've written elsewhere.
This is about dry fasting but it remains interesting in this context:

Cancer cells have multiple hallmarks and two of them are that (1) they don't burn glucose efficiently (this is called the Warburg effect) and (2) they contain too much water. By the way, genetic mutations found in cancer cells are also thought (not by the mainstream view) to be the consequence of the metabolic issues instead of a cause of cancer.

The Warburg effect is thought by some scientists to be due to the fact that oxygen has trouble reaching mitochondria, the site of glucose metabolism, so that "oxidative phosphorylation" (which is the name of the proper metabolism of glucose, involving oxygen) is not possible. Their explanation is that the Warburg effect is linked to the water excess. Here is an excerpt of a publication explaining this:

More than 80 years ago Nobel Prize laureate Warburg pointed out that in cancerous cell the loss of oxidative capacity of mitochondria and the glycolytic metabolism shift relative to oxidative phosphorylation as O2 could not reach to mitochondria. However, the nature of the primary mechanism leading to generation of Warburg phenomenon has not been elucidated yet.
In 1971 the second revolutionary discovery was made in cancer research by Raymond Damadian, who elucidated that cancerous cell is markedly overhydrated and can be much as 90% water while in norm it can be 70-73%. “Magnetic Resonance” method [2] of detection of cell over hydration suggested by him which serves as an early tumor detection diagnostic method at present has a worldwide clinical usage.
It is established that cell swelling triggers its proliferation, while cell shrinkage promotes its apoptosis [3-6]. Cell hydration causes not only the promotion of cell division and oncogene expression but also inactivates genes inducing cell apoptosis [7]. On the basis of these data cell over hydration was suggested as a primary messenger in carcinogenesis [3,7]. However, the nature of metabolic mechanism the dysfunction of which causes over hydration in cancer cells as well as the link between cell over hydration and Warburg phenomenon are also not elucidated yet. Therefore, it is suggested that the discovery of intracellular signaling pathway through which the correlation between cell hydration and mitochondrial function is realized could be one of the key problems of modern cancer research. [...]
As CO2 solubility in aqua medium is more than 20 times higher than O2 solubility [28], oxygen could not reach to mitochondria and would lead to generation of Warburg phenomenon. Therefore, prevention of generation of Warburg phenomenon can be achieved by both cell dehydration and the decrease of CO2 solubility in cytoplasm.

The Dysfunction of Metabolic Controlling of Cell Hydration Precedes Warburg Phenomenon in Carcinogenesis

Moreover, dry fasting might help with the release of the water excess (edema), as hypothesized in the following publication:

Despite the absolute Na+, K+, and water deprivation and the respective adjustments through Days 1–5, participants continued to excrete significant amounts of all three substances. Under this consideration, DF had natriuretic, diuretic, and kaliuretic effects. The natriuretic and diuretic effects contribute significantly to edema elimination. [...]
The association of adrenaline and EPO with both edema elimination (Fig. 2) and improved cellular oxygenation raises the question of whether edema elimination and improved cellular oxygenation are causally linked. This question is apparently of paramount therapeutic importance.

Dry Fasting Physiology: Responses to Hypovolemia and Hypertonicity

@alex155 thanks for describing what you experienced!

I tend to be on the higher side of blood pressure (before trying, and I don't measure it often), so that might be a good news.

It's possible that it should remain a short term diet (@heteronormie ).

@heteronormie thank you for joining the forum just to save my life

@LetTheRedeemed said in High Metabolism Keto possible?:

@NNight so there is a keto diet ?

Yes.
My first message is a reference about the "There is no Ray Peat diet" meme.

There are multiple ways to do it, which make them comparable with difficulty, when they are gathered under the same umbrella term. This is probably what causes the "paradox" you found.

Ps: I'm not defending keto diets, just proper reasoning.

@LetTheRedeemed
Yes, there are ketogenic dietS.
Drinking only seeds oil is one of them.

@LetTheRedeemed

There is no keto diet.

@Peatful
About Jimmy Moore (https://www.reddit.com/r/keto/comments/apbzv7/comment/eg7c7f0/) :

He's a glutton, that's the explanation. He gorges himself on unlimited fat and calories and eats low protein. He thinks if you don't eat HUGE amounts of fat, you become 'fat deficient'

It looks like the kcal haven't made him any favor.

He is very accessible on Reddit (on the r/saturatedfat subreddit) or on his blog. And I think he also like to do experiments. For example he just carried out a test measuring his "calories out" and which costs near 1000$ (if I remember correctly).

Thus, we might convince him to do cheap blood tests to find whether he really has high cortisol or other metrics?

@Jennifer said in cancer:

Ohh…it is you. Hi! If you haven’t done so already, you might be interested in reading Anita Moorjani’s book Dying to Be Me. She had a spontaneous healing (cancer) within days of having a near death experience. My only caution is if you’re religious, some of the things she says in it might bother you. She doesn’t talk negatively about religion, but what she experienced might be upsetting to those with certain belief systems.

Hi Could be an interesting story (and it's even available in french)! I'm always found of those cases that might help better understand these "incurable" diseases we are suffering from. And don't worry, I'm not religious even if I'm more interested in religion lately.

I can see dry fasting having a spiritual effect on us, and I completely agree that when disease has manifested, it’s a sign that our way of life needs an overhaul, at least, I know mine did, and it started and ended from within. This is just a theory based on my experience with a digestive disorder, thyroid supplementation, serotonin tests and dry fasting, but I suspect an increase in adrenaline, especially if coming from a low thyroid state, and a reduction in serotonin and endotoxin from not eating or drinking (or low irritation diets like carnivore) bring about extreme clarity, i.e., the brain fog has lifted, a heightening of senses and euphoria (think “runner’s high”). I liken it to what I’ve heard described as an LSD trip (antagonizes/blocks serotonin?) or the honeymoon effect where everything seems better—colors are more vivid, flavors are bolder, music is more inspiring, touch is more intense, and I’m in such a happy, giddy state and have so much love for everyone, not that I don’t normally, but it’s heightened. It’s as if I’m experiencing life for the first time. To me, it’s embodying the energy of a child where even a simple box provides hours of pleasure. I can be in an empty room and not want to be anywhere but there in the moment, my joy is coming from this inexhaustible, internal source, not a fleeting, external one.

Yes, dry fasting will increase alertness in some (or fatigue in others) and clearly increases stress hormones (more noradrenaline than adrenaline btw, which tends to decrease, it was found in a DF study). I don't know the exact mechanism linking dry fasting and potential spiritual experiences (it doesn't happen to everyone, far from it even) but as LSD trips, some people seem to keep benefits even long after the fast ended (spiritually or physically, if these can really be divided).

I’ve talked quite a bit about it on the old forum, but I can achieve the above state within days of doing what brings me joy, however, a more practical approach for those who have a hard time embracing it fully is dietary changes and I’ve talked with so many members who have experienced the same thing, even with simple changes to their diet, and read so many accounts in carnivore and fruitarian communities, so that’s a main reason why I’m such a proponent of diet customization, especially in advanced disease states. Ray talked about how our thoughts affect gut permeability and how eating foods that are tasty to us start the digestive process so I think there’s actually a sound, physiological reason for “religious” experiences and spontaneous healing with dietary modifications, following our joy and/or believing in something as powerful as the one who holds the patent to these meat suits we’re wearing (lol). It’s why I suggested the “grandmother” diet. IME, there’s something powerfully healing in feeling we are being cared for, that we’re not doing it all on our own. It’s the power of “working in conjunction with one another, incinerating anxiety and stress.” Perhaps one reason protocols work for many? There’s a power in group thinking.

Didn't know this idea of Peat!

Never tried carnivore nor fruitarian but I generally like what I eat.
I've reduced salt since about a month and unsalted food taste bland at first (so it decrease pleasure, at least initially I believe), then salted foods taste over-salted. What's interesting is I believe salt free might be a feature of both (some, not all) carnivores and fruitarian. Moreover, I think not mixing fats and carbs might lower hedonism too. Not that I think they don't enjoy their food.

Anita Moorjani went from following a cancer protocol (Gerson style) and dying, to falling into an NDE state where she was made aware that if she chose to come back to life and be herself fearlessly she would heal, and coming out of it having a spontaneous healing, while eating ice cream and dancing to ABBA’s Dancing Queen in her hospital room. She believed she would heal because she had no reason not to. However, even after her NDE and the revelation she had, when she was feeling rundown from giving talks about it around the world, she did what the majority of us who are firmly entrenched in this world do. She turned to the internet, started researching ways to feel better, got into smoothies and only got worse so she sat with herself and asked her body what it needed. Chicken and eggs came to mind so she went and boiled up some eggs, felt better almost immediately after having them and learned she just needed more protein. I quit following research and overthinking health, i.e., I relaxed my mind, which losing 20 years of research notes last year made easier, and fully dedicated myself to following my joy, and what took me 14 years of losing what was left of my sanity playing armchair researcher and biohacker, I achieved within months of letting go and I’m now climbing mountains again when I once couldn’t even walk, and this was even after suffering the greatest loss of my life.

I think disproportionately high focus on health research is induced by the diseased state and I can totally believe that it's a relief when you are successfully able to let it go! That's not what life is really about after all. But that's also a sign that you are not in a learned helplessness state.

There’s so much that can be said on the subject, but I don’t want to continue hijacking the thread. I hope whatever your experience with the Lourdes is, it’s an impetus that leads to greater understanding and wonderful, lasting health.

I'll try it soon and report it

@Jennifer said in cancer:

I can understand being afraid to be disappointed, sure. Even if the Lourdes water fails to produce any results, perhaps there’s still a lesson to be gained from the experience? Though, a faith healing I had years ago proved to be less than miraculous, I learned a valuable lesson from it.

Sure. Maybe I will discover it has done nothing for me. And that's really not an issue.

I have recently been interested in people having been healed at the same time with religious experiences. That's fascinating that people healed from such low health states, almost instantly for some.

In a book I've read about cancer spontaneous healing, it seemed like having a regain in religiosity was a healing factor. Also, often these people gained a deep positive view of life and saw their cancer diagnostic as a sign they needed to change their way of life.

Interestingly, (dry)fasting (I'm not here to proselytize about fasting sorry if it comes as such) has helped some people experiencing religious experiences but I hadn't this chance myself. That's why I'm "afraid" Lourdes water is not going to bring anything.

I reposted an interesting study (and some dry fasting / "religious experiences" testimonies in the same thread) on the RPF:
https://raypeatforum.com/community/threads/obesity-is-estrogen-driven-chronic-fasting-burns-mostly-muscle-not-fat.52177/post-972907

-> An excerpt from a book about it:

Spiritual epiphanies bubble into my thoughts while I dry fast, prompting me to feel as if I have a direct line to the etheric realm; I thought it might be because I had meditated for so many years. Thus, I didn’t mention it to the Lyme, mold, and Epstein-Barr patients I coached this year. I created individualized protocols for them before they embarked on lengthy dry fasts, but I didn’t think to mention, “Oh, by the way, you might have a spiritual awakening during the dry fasting.” To my astonishment, every one of them came to me in awe of the spiritual experiences they had. They would ask tentatively, “Is there a spiritual side to this?” The resounding answer is yes. Working in conjunction with one another, the body, mind, and spirit incinerate anxiety and stress, just as they destroy diseased cells. While you are literally starving, spiritual nutrition feeds you and strengthens your resolve.

@Jennifer said in cancer:

Take care.

Thanks, you too!

@ThinPicking said in cancer:

I'm very glad you're here.

Thanks!

@Jennifer said in cancer:

But what kind of water? Tap, well, spring, sea, distilled, RO, alkaline, deuterium-depleted, holy?

This is not a serious question but I answer it nonetheless: in theory, the less water the better, preferably deuterium-depleted.

By the way I have some from Lourdes in my fridge at the moment. I haven't tried it yet and I'm afraid to be "disappointed" (not that I have any specific expectations).

@ThinPicking Nope, I'm NNight 🥸

I'm currently trying a low salt diet along with water restriction. I want to see if it can be health promoting and thyroid boosting. I should probably measure body temp but I'm not used to measure it in the mouth or under the arm so I'm a bit lazy.

With a low salt diet, restricting water intake is quite easy, especially if you eat "damp" foods: vegetables like boiled potatoes or lettuce, well cooked rice, fruits like apples or bananas, unprocessed meat cooked rare, along with saturated fats like cream or butter on the potatoes. A small glass of water (about 250 mL) after meals is generally enough to never suffer any excessive thirst, or at all.

I'm a bit more permissive wrt. to my fluid intake right now due to the higher temperature here.

The diet can also be supplemented with osmolytes to make the process easier. I'm currently retrying a IP6+inositol supplement, with some boron, even if I've found it to be really too harsh stimulant last week, trying lower doses. Some betaine betaine could be a good addition too. Need to find a useful balance.

Since I started, my appetite for alcohol has reduced but it's among my goals to avoid drinking to much fluids (and thus avoid alcohol hangover) so that might just be a unconscious phenomenon.