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New IdeaLabs Product – 3α-Dihydroprogesterone (3α-DHP)

Literature Review
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  • A
    AinmBeo
    last edited by Oct 2, 2024, 2:05 PM

    By the way, the only alternative source for allop (aside from big lab companies like Sigma, which won't sell to citizens), is:
    https://russianstarpeptides.com/product/allopregnanolone-5mg-nasal-spray/
    Has anyone used this?

    P 1 Reply Last reply Oct 3, 2024, 11:46 AM Reply Quote 0
    • M
      Mauritio
      last edited by Oct 2, 2024, 2:47 PM

      Synchronicity strikes again!
      I was thinking about messaging you to ask if you can bring back 5aDHP because I like it so much.
      But 3aDHP seems close enough to try.

      Does it have the some anti-prolactin effect as 5aDHP?

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      W 1 Reply Last reply Oct 2, 2024, 11:26 PM Reply Quote 0
      • W
        wester130 @Mauritio
        last edited by Oct 2, 2024, 11:26 PM

        what did 5a dhp feel like?

        M 1 Reply Last reply Oct 3, 2024, 6:24 AM Reply Quote 0
        • M
          Mauritio @wester130
          last edited by Oct 3, 2024, 6:24 AM

          @wester130 like the sweet spot between dopamine and GABA with a little bit of progesterone in it.
          I did not get those effects from allopreg.

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          S 1 Reply Last reply Oct 3, 2024, 9:06 AM Reply Quote 0
          • S
            Sunniva @Mauritio
            last edited by Oct 3, 2024, 9:06 AM

            @Mauritio when did you use it during the day?

            "You're changing your past every time you learn something because you become a different organism" Ray Peat

            "Everything is changing thru time, whether it's a word, organism, thing. The world around it changes, and so its relationships change"Ray Peat

            1 Reply Last reply Reply Quote 0
            • P
              pannacottas @AinmBeo
              last edited by Oct 3, 2024, 11:46 AM

              @AinmBeo
              They are scammers, stay away

              W 1 Reply Last reply Oct 3, 2024, 9:25 PM Reply Quote 0
              • W
                wester130 @pannacottas
                last edited by Oct 3, 2024, 9:25 PM

                it would be interesting to see how this boosts Testosterone

                1 Reply Last reply Reply Quote 0
                • M
                  Mauritio
                  last edited by Oct 4, 2024, 3:17 PM

                  There's very little studies on this metabolite ...

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  W 1 Reply Last reply Oct 4, 2024, 4:26 PM Reply Quote 0
                  • W
                    wester130 @Mauritio
                    last edited by wester130 Oct 4, 2024, 5:21 PM Oct 4, 2024, 4:26 PM

                    @Mauritio

                    " 3α-DHP has also been found to inhibit the secretion offollicle-stimulating hormone (FSH) from the rat pituitary gland, demonstrating possible antigonadotropic effects "

                    "opioid antagonists, like naltrexone, have progonadotropic effects, and can increase luteinizing hormone and testosterone levels."

                    so are gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone bad for you?

                    should they be high or low?

                    M 1 Reply Last reply Oct 5, 2024, 11:10 AM Reply Quote 0
                    • B
                      bio3nergetic
                      last edited by Oct 4, 2024, 6:19 PM

                      In general, Ray warned against metabolites and downstream hormones.

                      M R 2 Replies Last reply Oct 5, 2024, 11:08 AM Reply Quote 0
                      • M
                        Mauritio @bio3nergetic
                        last edited by Oct 5, 2024, 11:08 AM

                        @bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        J 1 Reply Last reply Oct 19, 2024, 5:49 AM Reply Quote 0
                        • M
                          Mauritio @wester130
                          last edited by Oct 5, 2024, 11:10 AM

                          @wester130 well Ray wasn't fond of pituitary hormones so there's that

                          And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
                          Interestingly it only suppresses FSH and not LH.

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          1 Reply Last reply Reply Quote 0
                          • V
                            Verdad
                            last edited by Oct 5, 2024, 9:45 PM

                            Awesome @haidut! Keep it up your work is truly a light in the darkness.

                            W 1 Reply Last reply Oct 6, 2024, 12:40 PM Reply Quote 0
                            • W
                              wester130 @Verdad
                              last edited by wester130 Oct 6, 2024, 12:40 PM Oct 6, 2024, 12:40 PM

                              @Verdad you aren't worried about lowering gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone?

                              M 1 Reply Last reply Oct 6, 2024, 8:37 PM Reply Quote 0
                              • J
                                jorda11
                                last edited by Oct 6, 2024, 4:23 PM

                                @haidut is this best taken orally or on the skin

                                1 Reply Last reply Reply Quote 0
                                • M
                                  mexican_coke_fan @wester130
                                  last edited by Oct 6, 2024, 8:37 PM

                                  @wester130 Is this true? That would mean one's test would tank right?

                                  W 1 Reply Last reply Oct 6, 2024, 8:44 PM Reply Quote 0
                                  • W
                                    wester130 @mexican_coke_fan
                                    last edited by Oct 6, 2024, 8:44 PM

                                    @mexican_coke_fan the information is contradictory

                                    1 Reply Last reply Reply Quote 0
                                    • R
                                      risingfire @bio3nergetic
                                      last edited by Oct 7, 2024, 6:22 PM

                                      @bio3nergetic might shock you to find this out but Ray took testosterone at the end of his life. He didn't necessarily warn against but rather cautioned people taking downstream hormones.

                                      B G 2 Replies Last reply Oct 7, 2024, 11:25 PM Reply Quote 0
                                      • B
                                        bio3nergetic @risingfire
                                        last edited by Oct 7, 2024, 11:25 PM

                                        @risingfire No, not a shock. I was aware of the testosterone, but with his use at around a few mg max, with his fairly solid understanding that with something like testosterone, at a low dose, it was not only basically safe but also helpful, he never truly equated the downstream metabolite types to it. For the downstream metabolites, he clearly stated he thought they were unpredictable and not safe to take.

                                        R 1 Reply Last reply Oct 8, 2024, 1:12 PM Reply Quote 0
                                        • R
                                          risingfire @bio3nergetic
                                          last edited by Oct 8, 2024, 1:12 PM

                                          @bio3nergetic not sure where you're getting your information but testosterone is a downstream hormone

                                          B 1 Reply Last reply Oct 9, 2024, 12:35 AM Reply Quote 0
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