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New IdeaLabs Product – 3α-Dihydroprogesterone (3α-DHP)

Literature Review
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  • B
    bio3nergetic
    last edited by Oct 4, 2024, 6:19 PM

    In general, Ray warned against metabolites and downstream hormones.

    M R 2 Replies Last reply Oct 5, 2024, 11:08 AM Reply Quote 0
    • M
      Mauritio @bio3nergetic
      last edited by Oct 5, 2024, 11:08 AM

      @bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      J 1 Reply Last reply Oct 19, 2024, 5:49 AM Reply Quote 0
      • M
        Mauritio @wester130
        last edited by Oct 5, 2024, 11:10 AM

        @wester130 well Ray wasn't fond of pituitary hormones so there's that

        And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
        Interestingly it only suppresses FSH and not LH.

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        1 Reply Last reply Reply Quote 0
        • V
          Verdad
          last edited by Oct 5, 2024, 9:45 PM

          Awesome @haidut! Keep it up your work is truly a light in the darkness.

          W 1 Reply Last reply Oct 6, 2024, 12:40 PM Reply Quote 0
          • W
            wester130 @Verdad
            last edited by wester130 Oct 6, 2024, 12:40 PM Oct 6, 2024, 12:40 PM

            @Verdad you aren't worried about lowering gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone?

            M 1 Reply Last reply Oct 6, 2024, 8:37 PM Reply Quote 0
            • J
              jorda11
              last edited by Oct 6, 2024, 4:23 PM

              @haidut is this best taken orally or on the skin

              1 Reply Last reply Reply Quote 0
              • M
                mexican_coke_fan @wester130
                last edited by Oct 6, 2024, 8:37 PM

                @wester130 Is this true? That would mean one's test would tank right?

                W 1 Reply Last reply Oct 6, 2024, 8:44 PM Reply Quote 0
                • W
                  wester130 @mexican_coke_fan
                  last edited by Oct 6, 2024, 8:44 PM

                  @mexican_coke_fan the information is contradictory

                  1 Reply Last reply Reply Quote 0
                  • R
                    risingfire @bio3nergetic
                    last edited by Oct 7, 2024, 6:22 PM

                    @bio3nergetic might shock you to find this out but Ray took testosterone at the end of his life. He didn't necessarily warn against but rather cautioned people taking downstream hormones.

                    B G 2 Replies Last reply Oct 7, 2024, 11:25 PM Reply Quote 0
                    • B
                      bio3nergetic @risingfire
                      last edited by Oct 7, 2024, 11:25 PM

                      @risingfire No, not a shock. I was aware of the testosterone, but with his use at around a few mg max, with his fairly solid understanding that with something like testosterone, at a low dose, it was not only basically safe but also helpful, he never truly equated the downstream metabolite types to it. For the downstream metabolites, he clearly stated he thought they were unpredictable and not safe to take.

                      R 1 Reply Last reply Oct 8, 2024, 1:12 PM Reply Quote 0
                      • R
                        risingfire @bio3nergetic
                        last edited by Oct 8, 2024, 1:12 PM

                        @bio3nergetic not sure where you're getting your information but testosterone is a downstream hormone

                        B 1 Reply Last reply Oct 9, 2024, 12:35 AM Reply Quote 0
                        • B
                          bio3nergetic @risingfire
                          last edited by Oct 9, 2024, 12:35 AM

                          @risingfire There are far more downstream metabolite types from more primary downstream hormones than testosterone. That is what Ray meant, and that's what I am referring to.

                          R 1 Reply Last reply Oct 9, 2024, 3:38 PM Reply Quote 0
                          • R
                            risingfire @bio3nergetic
                            last edited by Oct 9, 2024, 3:38 PM

                            @bio3nergetic you should have just said metabolites. I think Ray would have experimented with DHT at some point had he still been alive

                            1 Reply Last reply Reply Quote 0
                            • J
                              jorda11
                              last edited by Oct 12, 2024, 6:42 PM

                              did anybody had good results with this
                              I personally did not feel anything locally and orally

                              1 Reply Last reply Reply Quote 0
                              • M
                                Mauritio
                                last edited by Oct 12, 2024, 8:02 PM

                                Only tried it once.
                                It feels pretty strongly anti-cortisol.
                                Also the next day my libido was a little higher and my muscles looked pretty full.

                                Thats all , I'm trying Melanon and lanosterol now so might be some time until I get back to 3aDHP.

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                1 Reply Last reply Reply Quote 0
                                • G
                                  Gardner @risingfire
                                  last edited by Oct 17, 2024, 9:25 PM

                                  @risingfire ,
                                  Did he really take testosterone ?

                                  Ray, "I told her about progesterone's general protective effects, its antagonism to testosterone, and its prevention of atrophy in various tissues. She decided to ask her doctor to try progesterone for her husband. Later, I learned that her husband had gone into a very rapid decline immediately after the injection, and died within a week; the physician had given him testosterone, since, he said, "testosterone and progesterone are both male hormones." Besides making me more aware of the problems patients have in communicating with physicians, this tended to reinforce my feeling that a hormone imbalance is involved in ALS. Although I haven't written much about testosterone's toxicity, Marian Diamond's work showed that prenatal testosterone is similar to prenatal estrogen, in causing decreased thickness of the cortex of the brain; both of those hormones oppose progesterone's brain-protecting and brain-promoting actions."

                                  R 1 Reply Last reply Oct 18, 2024, 3:16 PM Reply Quote 0
                                  • R
                                    risingfire @Gardner
                                    last edited by Oct 18, 2024, 3:16 PM

                                    @Goodman you need to look into the context. Too much testosterone can convert into estrogen. Plus there's a difference between prenatal vs a grown man in his 80's taking 1mg a day.

                                    1 Reply Last reply Reply Quote 0
                                    • J
                                      James @Mauritio
                                      last edited by Oct 19, 2024, 5:49 AM

                                      @Mauritio what cancer studies??

                                      M 1 Reply Last reply Oct 19, 2024, 8:29 AM Reply Quote 0
                                      • M
                                        Mauritio @James
                                        last edited by Oct 19, 2024, 8:29 AM

                                        @James the ones on 5aDHP and its effect on cancer.

                                        Dare to think.

                                        My X:
                                        x.com/Metabolicmonstr

                                        1 Reply Last reply Reply Quote 0
                                        • C
                                          cdwg
                                          last edited by cdwg Oct 23, 2024, 2:33 AM Oct 23, 2024, 2:06 AM

                                          @haidut said in New IdeaLabs Product – 3α-Dihydroprogesterone (3α-DHP):

                                          0.01-1.0 microgram

                                          @haidut correct me if I'm inaccurate, please.

                                          1 drop of this product for R&D is about double the dose used in the quoted studies above for HED. (I used Copilot to convert the dosage).

                                          On the older AlloP and 5α-DHP pages, the common max R&D dose was 10 drops.

                                          20d1cd79-5fbb-4216-ae32-80b9cff31033-image.png

                                          If anyone is interested, I like the following stack for busy days. Helped me a lot mitigating the stress when interfacing with a panel of directors and VPs.

                                          Morning/Evening Dose:
                                          1 drop lisuride - topical
                                          1 drop cypro - oral
                                          2 drops androsterone - topical
                                          2 drops 3α-DHP - oral

                                          M 1 Reply Last reply Oct 23, 2024, 3:49 PM Reply Quote 0
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