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New IdeaLabs Product – 3α-Dihydroprogesterone (3α-DHP)

Literature Review
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  • S
    Sunniva @Mauritio
    last edited by Oct 3, 2024, 9:06 AM

    @Mauritio when did you use it during the day?

    "You're changing your past every time you learn something because you become a different organism" Ray Peat

    "Everything is changing thru time, whether it's a word, organism, thing. The world around it changes, and so its relationships change"Ray Peat

    1 Reply Last reply Reply Quote 0
    • P
      pannacottas @AinmBeo
      last edited by Oct 3, 2024, 11:46 AM

      @AinmBeo
      They are scammers, stay away

      W 1 Reply Last reply Oct 3, 2024, 9:25 PM Reply Quote 0
      • W
        wester130 @pannacottas
        last edited by Oct 3, 2024, 9:25 PM

        it would be interesting to see how this boosts Testosterone

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        • M
          Mauritio
          last edited by Oct 4, 2024, 3:17 PM

          There's very little studies on this metabolite ...

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          W 1 Reply Last reply Oct 4, 2024, 4:26 PM Reply Quote 0
          • W
            wester130 @Mauritio
            last edited by wester130 Oct 4, 2024, 5:21 PM Oct 4, 2024, 4:26 PM

            @Mauritio

            " 3α-DHP has also been found to inhibit the secretion offollicle-stimulating hormone (FSH) from the rat pituitary gland, demonstrating possible antigonadotropic effects "

            "opioid antagonists, like naltrexone, have progonadotropic effects, and can increase luteinizing hormone and testosterone levels."

            so are gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone bad for you?

            should they be high or low?

            M 1 Reply Last reply Oct 5, 2024, 11:10 AM Reply Quote 0
            • B
              bio3nergetic
              last edited by Oct 4, 2024, 6:19 PM

              In general, Ray warned against metabolites and downstream hormones.

              M R 2 Replies Last reply Oct 5, 2024, 11:08 AM Reply Quote 0
              • M
                Mauritio @bio3nergetic
                last edited by Oct 5, 2024, 11:08 AM

                @bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                J 1 Reply Last reply Oct 19, 2024, 5:49 AM Reply Quote 0
                • M
                  Mauritio @wester130
                  last edited by Oct 5, 2024, 11:10 AM

                  @wester130 well Ray wasn't fond of pituitary hormones so there's that

                  And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
                  Interestingly it only suppresses FSH and not LH.

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • V
                    Verdad
                    last edited by Oct 5, 2024, 9:45 PM

                    Awesome @haidut! Keep it up your work is truly a light in the darkness.

                    W 1 Reply Last reply Oct 6, 2024, 12:40 PM Reply Quote 0
                    • W
                      wester130 @Verdad
                      last edited by wester130 Oct 6, 2024, 12:40 PM Oct 6, 2024, 12:40 PM

                      @Verdad you aren't worried about lowering gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone?

                      M 1 Reply Last reply Oct 6, 2024, 8:37 PM Reply Quote 0
                      • J
                        jorda11
                        last edited by Oct 6, 2024, 4:23 PM

                        @haidut is this best taken orally or on the skin

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                        • M
                          mexican_coke_fan @wester130
                          last edited by Oct 6, 2024, 8:37 PM

                          @wester130 Is this true? That would mean one's test would tank right?

                          W 1 Reply Last reply Oct 6, 2024, 8:44 PM Reply Quote 0
                          • W
                            wester130 @mexican_coke_fan
                            last edited by Oct 6, 2024, 8:44 PM

                            @mexican_coke_fan the information is contradictory

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                            • R
                              risingfire @bio3nergetic
                              last edited by Oct 7, 2024, 6:22 PM

                              @bio3nergetic might shock you to find this out but Ray took testosterone at the end of his life. He didn't necessarily warn against but rather cautioned people taking downstream hormones.

                              B G 2 Replies Last reply Oct 7, 2024, 11:25 PM Reply Quote 0
                              • B
                                bio3nergetic @risingfire
                                last edited by Oct 7, 2024, 11:25 PM

                                @risingfire No, not a shock. I was aware of the testosterone, but with his use at around a few mg max, with his fairly solid understanding that with something like testosterone, at a low dose, it was not only basically safe but also helpful, he never truly equated the downstream metabolite types to it. For the downstream metabolites, he clearly stated he thought they were unpredictable and not safe to take.

                                R 1 Reply Last reply Oct 8, 2024, 1:12 PM Reply Quote 0
                                • R
                                  risingfire @bio3nergetic
                                  last edited by Oct 8, 2024, 1:12 PM

                                  @bio3nergetic not sure where you're getting your information but testosterone is a downstream hormone

                                  B 1 Reply Last reply Oct 9, 2024, 12:35 AM Reply Quote 0
                                  • B
                                    bio3nergetic @risingfire
                                    last edited by Oct 9, 2024, 12:35 AM

                                    @risingfire There are far more downstream metabolite types from more primary downstream hormones than testosterone. That is what Ray meant, and that's what I am referring to.

                                    R 1 Reply Last reply Oct 9, 2024, 3:38 PM Reply Quote 0
                                    • R
                                      risingfire @bio3nergetic
                                      last edited by Oct 9, 2024, 3:38 PM

                                      @bio3nergetic you should have just said metabolites. I think Ray would have experimented with DHT at some point had he still been alive

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                                      • J
                                        jorda11
                                        last edited by Oct 12, 2024, 6:42 PM

                                        did anybody had good results with this
                                        I personally did not feel anything locally and orally

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                                        • M
                                          Mauritio
                                          last edited by Oct 12, 2024, 8:02 PM

                                          Only tried it once.
                                          It feels pretty strongly anti-cortisol.
                                          Also the next day my libido was a little higher and my muscles looked pretty full.

                                          Thats all , I'm trying Melanon and lanosterol now so might be some time until I get back to 3aDHP.

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          1 Reply Last reply Reply Quote 0
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