Experiments with transdermal hormones
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@yeyo12 there was a post on old rpf about how using honey removes the smell. If you want a DMSO formula Id use 70 DMSO : 20 Vit E : 10 honey
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@metabolicmilk
What is your goal with this?Which testosterone & DHT bases are good for topical application? (fromPPL)
Also whats the Exemestane for?
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@metabolicmilk what other results are you getting?
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@Kilgore anti E
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@wester130 grow bigger while losing fat. It's working.i feel like my bones are growing
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I put DHT GEL on my Nether-Regions: Insane EQ, Painful B*ners, Masculinity, and SIDE EFFECTS
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@metabolicmilk I agree it can have strong health effects. Its interesting how some people here are wondering why so many are interested in DHT here. It has some of the most potent anti stress effects a molecule can have and literally is produced in healthy men. When one gets into a stressfull state testosterone will slowly decline in comparison to DHT which plummits. Its extremely anti estrogenic, pro gaba, anti adrenaline, anti cortisol, anti inflammatory. I think the people who didnt notice anything either needs to improve their health situation abit more first, or wasnt eating nearly enough. I would consume 6-7k calories when I was top health and was completely shredded. In this state my natural test was higher than avarage but my dht was extremely high. Later I started also adding 11-keto dht and androsterone and saw even more benefits. After alot of stress and lack of good food for 1.5 year the thing that helps me recover to my old state faster is not only good food, but also hormones...
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What do you guys think about a solution like this?
30mg T
5mg DHT
5mg DHEA
5mg Progesteroneper 1ml Vitamin E.
What about adding pregnenolone?
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@Kilgore I could not get T to dissolve in a reasonable amount of Vit E. It's just not a good solvent alone. There's a thread somewhere that I posted in awhile ago.
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@Kilgore That's a good plan, I would take it orally though, not transdermally. The biggest issue I faced with creating a vitamin E steroid solution, was finding the right vitamin E solvent; 1.) Many Vitamin E / Tocopherol oils, are either alpha or mixed tocopherols diluted heavily with a seed oil like sunflower oil or wheat germ oil. 2.) Some are sold as "vitamin E oil / tocopherol oil" but are actually only wheat germ oil, due to it's high vitamin e content.
Both alpha and mixed tocopherol work equally as well, according to haidut via email.
I use https://www.mysticmomentsuk.com/products/vitamin-e-natural-vitamins?variant=2738367922200
It's 70% mixed tocopherols and 30% sunflower oil, which of course isn't perfect, but the sunflower oil consumed is minimal. It's the best value source of high-concentration vitamin E oil I could find in europe/UK, despite it using more expesnive mixed tocopherols. I couldn't find affordable alpha tocopherol oils in Europe, and this mixed tocopherol product is more concentrated and cheaper than any tocopherol oil I could find on iHerb. -
@Crypt-Keeper I can personally make a progesterone and DHEA vitamin E solution, where I can dissolve 150mg of each into 1ml of vitamin E. So that's a 30% solution of DHEA and progesterone dissolved in vitamin E.
I pre heat the tocopherol first in the microwave to a high temperature, and then throw in the powders, swirl them vigorously, and put it back in the microwave, and warm the solution, and swirl it again vigorously. I then inspect the oil by shining a light through the bottom of the jar I brew the solution in, and I can see little to no undissolved hormone.
I failed to make a pregnenolone solution with vitamin E at first; but I found out that the trick to making steroid solutions whether that be in vitamin E, or benzyl benzoate with steroid esters, is to pre heat the solution well before adding the hormones in.
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@alfredoolivas said in Experiments with transdermal hormones:
That's a good plan, I would take it orally though, not transdermally.
Why?
Earlier in this thread Brightside explained the benefits of transdermal application over oral:
Few reasons. For me, injection seems like a primitive method, while topical is a much more elegant solution. But the general reasons would be:
risk of infection
introducing needless PUFAs
long term suppression and need for PCT to stop
more of a commitment/big deal to do (buying potentially contaminated UGL gear or going to a TRT clinic)
more often a need for AI (since topical generates more DHT)Additionally, this is only for TRT, but people might want to use other hormones like P5, P4, DHEA, DHT, Exe, 5aDHP, etc. Using topically is convenient and can offer a high absorption compared to oral, or it can provide an alternate metabolism. (like in the case of DHEA or T).
I like these benefits, but I have 0 experience with any of this so I am open to any ideas.
As for the Vitamin E I have is from NOW. I know its not the best but I don't mind it for a first try. Next time I might try this as it was recommended to me by a fellow peater.
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@Crypt-Keeper Thanks I'll look through it.
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@Uncover Well said.
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I mix progesterone with vitamin E powder and some drops of coconut oil.
I don't make a solution to store. I simply put the day's ingredients on a spoon, mix with a finger for 2 seconds, and apply directly to my gums.
I store coconut oil in this dropper container
https://www.amazon.co.uk/gp/product/B0BY8Y6S8Z/I use this Vitamin E powder (the capsules are easy to open)
https://www.timehealth.co.uk/product/vitamin-e-complex/ -
@Kilgore vitamin d, especially micellised vitamin D, would amplify the mixture a lot
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@Kilgore Ray said only 20% of vitamin E is absorbed when applied topically. However, he claimed that steroids dissolved in vitamin E have close to 100% absorption when taken orally. This is why he always referred to oral administration when referring to Progest E.
Topical application of steroids dissolved in vitamin E does have the benefit of slow, sustained absorption. However, if you wish to absorb a desired dose of steroids, such as 10mg of testosterone, you will need to apply 5x more solution because only 20% will be absorbed; this would require you to use 5x more steroids and 5x more vitamin E, and funnily enough, using 5x more vitamin E is the main issue here, because vitamin E is an expensive solvent and applying large amounts of vitamin E oil, is very tricky due to it creating oily skin (as it is not readily absorbable, compared to ethanol or DMSO).
Vitamin E "Oil" from NOW. has 510mg of alpha-tocopherol per 1ml, so you can probably dissolve 50-100mg of steroids in there, per ml, with ease. The NOW Vitamin E "Liquid" has 300mg of alpha-tocopherol per 1 ml, so you can probably dissolve 30-60mg of steroids per ml of oil with ease.
The NOW Vitamin E-Oil with "Mixed Tocopherols" has a 58mg amount of alpha-tocopherol per ml; I don't know how much of the other isomers it has, such as gamma-tocopherol, so I wouldn't use that immediately. I am sure NOW customer service will tell you how much total mixed tocopherols is contained within a serving.
The product that you linked me, is 100% tocopherol solution; very good, much better value than NOW products. A way to see the concentration of vitamin E oil, inside a product is to see the IU per ounce. This product has 42,500 IU of d-alpha tocopherol per oz, which means that there is 28,475mg of d-alpha tocopherol per oz (multiply IU by 0.67 to convert to milligrams). So it is pure tocopherol, and it says also so in the ingredients list.
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would the vitamin E powder dissolved in ethanol produce the same results as fat soluble vitamin e?
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@wester130 I have no idea how soluble steroids are in the artificial vitamin E esters dissolved in ethanol. I have used artificial vitamin E, in the form of dl alpha-tocopherol oil (the natural alpha tocopherol is d alpha tocopherol), and it worked. It had a bad taste, whereas mixed tocopherols taste okay.
My advice is don’t cheap out, use the tried and tested natural tocopherol oils, you can find sources on this thread.
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@alfredoolivas Thanks. My main concern is the long term suppression and need for PCT to stop part really.
I might even just make 2 different solutions; one to apply topically (T,DHT) and one to take orally (DHEA,Progesterone,Pregnenolone).
@alfredoolivas said in Experiments with transdermal hormones:
Vitamin E "Oil" from NOW. has 510mg of alpha-tocopherol per 1ml, so you can probably dissolve 50-100mg of steroids in there, per ml, with ease.
I have a couple bottles of those. I haven't ordered the powders yet since PPL is out of stock on DHT.
