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    Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?

    Literature Review
    holy basil tulsi testosterone thyroid
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    • MauritioM
      Mauritio
      last edited by Mauritio

      Here's another cool study for basil (O. basilicium, NOT holy basil) on Testosterone.

      If anyone is still following this thread at this point you might want to go for basil not holy basil. Or both. I just haven't seen a single negative study on basil in relation to testosterone and for holy basil there are a few.

      In arsenic treated rats it was able to almost completely restore their testosterone values to normal . Unfortunately they didn't have a control+ basil group , but basil almost tripled the T value of the arsenic treated rats compared to only arsenic treated rats. It also restored sperm health and testes weight and increased antioxidant enzymes drastically .

      All of this especially at the highest dose of 500mg/kg, HED= 6g of O. Basilicum 95% alcohol extract.

      https://www.researchgate.net/publication/356840663_Potential_ameliorative_effects_of_Ocimum_basilicum_extract_and_leaves_on_testicular_toxicity_induced_by_sodium_arsenite_in_male_rats

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      1 Reply Last reply Reply Quote 0
      • MauritioM
        Mauritio
        last edited by

        There might be a few MAO-B inhibitors in basil.
        https://pubmed.ncbi.nlm.nih.gov/32883197/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        1 Reply Last reply Reply Quote 0
        • cs3000C
          cs3000
          last edited by cs3000

          O. basilicium water extract fully restored glucose & insulin measures in diabetes model
          https://scialert.net/fulltext/?doi=pjbs.2020.1010.1017
          increases glucose uptake by cells
          c89a6be9-7c4b-4678-a198-652feab2748f-image.png

          & increased sleep duration on a sedative more than diazapam , decreased time taken to fall asleep a couple minutes by itself (through GABA) so maybe best timing is PM https://pmc.ncbi.nlm.nih.gov/articles/PMC5020426/#sec162951
          extract with both water & ethanol solubles had greatest effect (potential for gaba rebound though)

          "world," as a source of new perceptions
          more https://substack.com/@cs3001

          "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

          1 Reply Last reply Reply Quote 0
          • MauritioM
            Mauritio
            last edited by Mauritio

            Another reason to favor O. Basilicum !
            Yeah it does have a glucose lowering effect. There's a few studies on basil as a diabetes treatment . I notice the hypoglycemic effect.

            Interesting in that dosage it actually caused sleep issues for me . Although that was O. Sanctum and not O. Basilicum as in this study.

            In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
            https://pubmed.ncbi.nlm.nih.gov/36750371/

            Although in this study it showed no effect on sleep.
            https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

            Dare to think.

            My X:
            x.com/Metabolicmonstr

            cs3000C 1 Reply Last reply Reply Quote 0
            • MauritioM
              Mauritio
              last edited by

              "The biochemical parameters of hepatic function, renal function, glucose, triglyceride, and cholesterol level were significantly reduced in the treatment groups compared with the control group (p < 0.05)"

              https://pubmed.ncbi.nlm.nih.gov/39555564/#&gid=article-figures&pid=figure-1-uid-0

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              1 Reply Last reply Reply Quote 0
              • cs3000C
                cs3000 @Mauritio
                last edited by cs3000

                @Mauritio
                looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

                In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
                https://pubmed.ncbi.nlm.nih.gov/36750371/
                Although in this study it showed no effect on sleep.
                https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

                so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

                "world," as a source of new perceptions
                more https://substack.com/@cs3001

                "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                MauritioM 1 Reply Last reply Reply Quote 0
                • H
                  Hearthfire
                  last edited by

                  I've grown basil the last few years, it's amazing in stir fry. I got almost addicted to it, I wonder if my body was craving the effects it was having without me consciously noticing 🤔

                  I know what I'm definitely growing again this year 😁
                  I'll probably do italian basil and holy basil to test out both.

                  MauritioM 1 Reply Last reply Reply Quote 0
                  • MauritioM
                    Mauritio @cs3000
                    last edited by

                    @cs3000 said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

                    @Mauritio
                    looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

                    In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
                    https://pubmed.ncbi.nlm.nih.gov/36750371/
                    Although in this study it showed no effect on sleep.
                    https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

                    so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

                    Even the microdose (30mg) caused waking up to early for me. It felt like hypoglycemia, woke up with a pounding heart.

                    But maybe you're onto something with the GABA theory. GABA rebound is real.

                    I obtained dried powder of both basils and will continue experimenting.

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

                    1 Reply Last reply Reply Quote 0
                    • MauritioM
                      Mauritio @Hearthfire
                      last edited by

                      @Hearthfire nice they used fresh basil in some studies so that's probably the best way to go!

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      W 1 Reply Last reply Reply Quote 0
                      • W
                        wester130 @Mauritio
                        last edited by

                        could the alcohol tincture be used topically?

                        1 Reply Last reply Reply Quote 0
                        • MauritioM
                          Mauritio
                          last edited by

                          Yesterday I did 1g of basil (O. Basilicum)powder.

                          I took it in the morning and it had a strong relaxing /anti cortisol effect on me.
                          Muscles looked very full and less water retention as well.
                          During the afternoon I became a bit irritable and serotonergic ,but not sure if related at all. Might be due to gut issues from the day before.
                          I also felt quite confident and masculine. Totally recommend. Will try again .

                          And the best part was it didn't mess with my sleep like in my previous experiments with holy basil.
                          It was a bit harder to fall asleep but I didn't wake up early.
                          Maybe that was because it was basil and not holy basil this time, but maybe it was me taking it so early that the GABA rebound was over when i went to sleep.
                          I also took some limonene in the evening which increases GABA so maybe that flatened the GABA issues.

                          Today I woke up weighing 500g less and muscles looking Big and full . I had no morning wood today which is unusual . But some androgenic substances do that to me.

                          I still want to try 500mg and 25mg to see how that feels in comparison.

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          H 1 Reply Last reply Reply Quote 0
                          • H
                            Hearthfire @Mauritio
                            last edited by

                            @Mauritio Interesting. Keep us posted.

                            I gotta order a bunch of seeds soon. I'm gonna grow a ton of it to experiment with and put in stir fry.

                            1 Reply Last reply Reply Quote 0
                            • L
                              lobotomize-me
                              last edited by

                              Just bought 4 basil plants and whenever i eat couple g of basil my voice drops extremely low, never seen such crazy effects in my life.

                              MauritioM 1 Reply Last reply Reply Quote 0
                              • MauritioM
                                Mauritio @lobotomize-me
                                last edited by

                                @lobotomize-me nice any other androgenic effects?

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                L 1 Reply Last reply Reply Quote 0
                                • L
                                  lobotomize-me @Mauritio
                                  last edited by lobotomize-me

                                  @Mauritio I had a game on the first day I took basil. You can read more about my experience in my other post. Although the game started off badly, on the way there I was super confident, joking with friends, feeling what i can describe as a extremly dht dominant state, and I truly felt like a "ruler" instead of a sheep.

                                  The confidence seemed to fade during warm up, I wasn't unconfident, just silent and passive mentally. Even if I made a mistake, I didn't care too much what i felt could be described as a seratonin dominant state , putting my head down (I'm still trying to understand why this happens). When the game began, I fell into an extremely seratongenic state where everything just happened around me. I lost the ball multiple times and performed poorly(with hindsight i can remember me thinking as if i am in a cage trying to survive), so I asked my coach to substitute me off.

                                  I talked with him and requested to be put back in after a few minutes he complied. Seeing my team struggle on the field made me angry and motivated. I told my coach I was ready, he put me back in, and then I dominated the other team.

                                  At that moment, I genuinely felt like a ruler I can't fully describe it, but it felt incredible. I played amazingly, felt highly confident, had a high drive, commanded my team with helpful feedback, and overcame mistakes quickly. I'm not sure if basil had anything to do with this, but this was my full experience after taking sweet basil(High confidence/DHT dominance, although when faced with physical and mental pressure, suffered from a serotonergic state).

                                  (Hope you can also help me figure out how to replicate the experience I had the second time I was substituted in and help me avoid entering the sheepish state of mind)

                                  MauritioM 1 Reply Last reply Reply Quote 0
                                  • MauritioM
                                    Mauritio @lobotomize-me
                                    last edited by

                                    @lobotomize-me Interesting. Hard to say.
                                    I wouldnt take it right before a game tbh. Its too anti-cortisol. The serotonergic state you describe could simply be that : no energy due to lack of cortisol. That can make you pretty fatigued when T3 isnt there to pick you up.

                                    Maybe try the night before the game.

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    L 1 Reply Last reply Reply Quote 0
                                    • LukeL
                                      Luke
                                      last edited by

                                      After reading the reports in this thread I bought a box with some dried basil powder, the one you can find in every grocery store among the spices. I'm not sure if it's as potent as fresh basil or concentrated powder, but I notice that I'm more relaxed and less stressed afterwards. I just take about a teaspoon and chew on it for two or three minutes before I swallow it (I find the taste quite pleasant and could imagine that the ingredients are good for the teeth, although that's speculation). Basil definitely peaked my interest.

                                      I also bought the tulsi extract from Sunday Naturals that @Mauritio mentioned in this thread. The results are more mixed. The first day I took an entire capsule around noon and didn't notice much. Felt stressed beforehand and felt stressed afterwards. With smaller doses it gives me a relaxing effect. I wonder why the tea gives me better results. Maybe it's just the dose and the dose of a full capsule is just too high. Last Sunday I made a camomile tea and poured the content of a tulsi capsule into the cup as well. I slept pretty well that night (by my standards). There seems to be something about tea that agrees more with me than a concentrated powder. Maybe I was an Englishman in a former life.

                                      I've never been a big party attender, but I never went to a party where I didn't probably offend most of the people there by talking about what I was interested in. (Ray Peat)

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                                      • L
                                        lobotomize-me @Mauritio
                                        last edited by

                                        @Mauritio but wouldnt me being/feeling as if i am a sheep in a cage indicate that i have too much cortisol/stress?

                                        Plus i just realised the active compound in basil is rosmarinic acid which i saw you mentikned in another thread is Immunosuppressive

                                        MauritioM 1 Reply Last reply Reply Quote 0
                                        • MauritioM
                                          Mauritio @lobotomize-me
                                          last edited by

                                          @lobotomize-me yeah it would . But maybe it's from something else.

                                          Why is rosmarinic acid the main active component ?

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          L 2 Replies Last reply Reply Quote 0
                                          • KvirionK
                                            Kvirion
                                            last edited by

                                            Just a field report...
                                            I tried Holy Basil today. I didn't notice much effect.
                                            Probably, some anti-inflammatory (maybe TSH lowering one?) and a bit cortisol/adrenaline lowering one, but since I have my cortisol pretty under control this wasn't any significant change.
                                            No change in body temperature or libido.

                                            A little learning is a dangerous thing ;
                                            Drink deep, or taste not the Pierian spring :
                                            There shallow draughts intoxicate the brain,
                                            And drinking largely sobers us again.
                                            ~Alexander Pope, An Essay on Criticism

                                            MauritioM 1 Reply Last reply Reply Quote 0
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