Methylene Blue
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@Tahodama specific thing that's in milk and cheese. forgot the name.
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@CO3 tyramine
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@onliest
Ah, looking it up now. Yeah that explains it. I'm also reading that pasteurized dairy (both present in my smoothie and cheesecake) are low in tyramine, which explains why I didn't feel any symptoms of high BP. I was also taking ~1g of aspirin before bed which may've helped.
Still intrigued I didn't notice any drastic changes in my hormone profile. Or maybe I'm just horribly unobservant. -
Thinking of starting supplementing Methylene Blue as I'm having some low blood oxygen issues. Anybody have some useful info on what would be a good daily dose? Thanks:)
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@Erika I'd start with 1-2mg and avoid other MAO inhibitors to be safe.
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@Lothric wow that is a really high dose. I started taking it last week (took one bottle from the lab at Uni) and just 3 drops are enough for me to feel the nootropic effects. The other day I tried taking like 9 drops through the day and i started peeing blue-ish green, so I wouldn't recommend taking that much as you can feel the effect with 1-2 drops in like half liter of water.
Anyways I'm a rookie with Methylene blue it's just my opinion analysing the start of my usage.
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@Erika I started a week ago with it, I couldn't find specific recommendations for a nootropic use. I just pour 3 drops in like half a liter of water and drink it with calm without rush. I feel the effects on my cognitive skills so for sure it's having effect on cardiovascular system and cellular levels too. That's my advice as someone that just started. Once i tried to put 3 drops directly to the tongue but the flavour is not so pleasant and you feel the intensity of it too much.
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@Martiño Interesting, I didn't know the nootropic effect was a thing. Definitely excited if it will have some effect of my mood. Thank you for sharing your experience with it.
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I have the mb from Idealabs called oxidal. I only take one drop every other day.
I hear you shouldnt take it with coffee. Yet there's caffeine in the bottle.
How does that work? I have put it in my coffee so I'm wondering if I shouldnt -
@CO3 Do you have any actual evidence that 7mg (likely 0.1 mg/kg) is "high dose"? It's used at 15-60 mg per diem for all sorts of mental health disorders and was used at doses far beyond that in world war I for months.
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@CO3 Lactoferrin probably
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@happyhanneke It potentiates the effect of the caffeine meaning any caffeine co-adminstered with the MB makes the effect of the caffeine as if you had taken approx a 10x dose of caffeine. So, if you take MB with 10 mg caffeine, you get an effect from the caffeine as if you had taken 100mg caffeine.
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@jamezb46 That is not true, I am pretty sure that idea was conjecture, spread by Haidut back in the day. I have had 600mg of caffeine and 10-15mg caffeine on the same day, and no, it felt like 600mg of caffeine not 6000mg.
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@alfredoolivas yes that’s where I got the idea. But maybe it’s true at low doses and not high. In other words maybe the potentiation is 10x at very low doses of caffeine like 1 mg but approaches 1x as the amount increases toward some value like maybe 10mg caffeine.
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afaicr (as far as I can recall) 5mg MB 3x a day is the safu dose for self-treating various issues. it's interesting because 5mg 3x a day is the safe DHEA dose too
peat is more conservative and iirc recommended like 70mcg as a safe dose. The quote from him says to take it in similar doses as thyroid hormone.
. for general wellness (a supplement you take for health benefits that you don't really obliquely notice acute effects from), something like 0.5mg a day is probably totally fine. don't take it with iron rich foods or vitamin E
I took like 100-150mg a day for like 2 weeks during wuflu. I can't say if it really helped. I have a suspicion it caused or contributed to what I think is iron lipofuscin on my finger that gradually disappeared since. I was also on a whack of cyproheptadine so that would have mitigated any potential excess serotonin effects.
the first time I ever took MB at like a 1mg dose I got this strange and not totally unpleasant sensation that my vision was widening and getting better.
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@sushi_is_cringe
Yes, the 5 mg, 3x per day sounds right. 15 mg/day is where some of the clinical trials start with mental illness sufferers like depression.
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@jamezb46 Haidut says a lot of stuff man... here is a clip of him saying a few mgs of exemestane, allows him to drink 2 litres of Vodka in a single night. In most countries that is equivalent to 67 shots of vodka...
Youtube Video – [1:17:50..]I wouldn't take his words as gospel.