Niclosamide reduces serotonin and glutamate

Mauritio

@war4512 said in Niclosamide reduces serotonin and glutamate:

@war4512 I’ll read more about niclosamide today because it seems to me that a single study is not necessarily conclusive on this matter. Especially since it was a study conducted on carp.

Agreed.
Of course there is glycogen depletion at first when you increase your metabolism. But if that was the cause the weight loss would have shown the next day and not the day after that . Plus glycogen is quickly refilled when having meals.

The opposite of what you said concerning glycogen might even be what's happening.
Subjectively I notice that I can go alittle longer between meals and my muscles look fulller.

The paragraph you quoted merely describes how niclosamide kills parasites.
Yes that happens through uncoupling, and yes if we uncoupled our metabolism too much we would die too (ever heard of DNP?) .
That does not make physhological ucoupling unhealthy . the lowering of ATP is made up for by increases in temperature and metabolism and reduction in oxidative stress.

I suggest you read about the basics and benefits of uncoupling and their effects on humans. Georgi has a lot of good content on that.

war4512

@Mauritio said in Niclosamide reduces serotonin and glutamate:

Of course there is glycogen depletion at first when you increase your metabolism. But if that was the cause the weight loss would have shown the next day and not the day after that . Plus glycogen is quickly refilled when having meals.

Well, if you've noticed that your muscles are fuller, it’s probably because you are compensatorily consuming large amounts of glucose. T3 also has some ability to reduce glycogen, but this depends on the dose and metabolism. When I take thyroid hormones, I also notice that I’m fuller, but that’s because I consume around 600/700g of carbohydrates a day, which has a compensatory effect.

@Mauritio said in Niclosamide reduces serotonin and glutamate:

I suggest you read about the basics and benefits of uncoupling and their effects on humans. Georgi has a lot of good content on that.

I’m familiar with the process of uncoupling. It’s an extraordinary mechanism, but as I mentioned, it depends on the substance or another physiological factor that induces it. PUFA, for example, also promote uncoupling, but through PPAR-gamma, impairing biogenesis, which T3 does not do. However, if there is a noticeable increase in lactate, it is probably related to limiting OxPHOS, resulting in increased glycolysis.

@Mauritio said in Niclosamide reduces serotonin and glutamate:

The paragraph you quoted merely describes how niclosamide kills parasites.
Yes that happens through uncoupling, and yes if we uncoupled our metabolism too much we would die too (ever heard of DNP?) .

I fully agree, however, the pharmacological action of niclosamide on parasites should also have systemic effects. I didn’t say that mitochondrial uncoupling is bad – it depends on the substance that causes it. For example, T3 also uncouples mitochondria, but it has a beneficial effect. There are also uncoupling substances that cause negative symptoms.

Mauritio

@war4512 said in Niclosamide reduces serotonin and glutamate:

Well, if you've noticed that your muscles are fuller, it’s probably because you are compensatorily consuming large amounts of glucose.

As i said susected its probably from higher glycogen synthesis, which was almost twice as high.

"Moreover, the NEN-treated mice exhibited higher glycogen synthesis rates (Table 1), which were further confirmed by a direct measurement of glycogen synthesis showing higher rates in both liver and muscle (data not shown)."
https://pmc.ncbi.nlm.nih.gov/articles/PMC4299950/

Mauritio

Here are a few resources for further reading on uncoupling

"When mitochondria are “uncoupled,” they produce more carbon dioxide than normal, and the mitochondria produce fewer free radicals. Animals with uncoupled mitochondria live longer than animals with the ordinary, more efficient mitochondria, that produce more reactive oxidative fragments. One effect of the high rate of oxidation of the uncoupled mitochondria is that they can eliminate polyunsatured fatty acids that might otherwise be integrated into tissue structures, or function as inappropriate regulatory signals."
Ray Peat

https://lowtoxinforum.com/threads/vos-uncoupling-thread.5037/

https://lowtoxinforum.com/threads/uncoupling-increases-life-span-and-generates-more-mitochondria.29283/

https://lowtoxinforum.com/threads/uncoupling-increases-t3.40540/

https://lowtoxinforum.com/threads/uncoupling-metabolism-oxphos-may-treat-inflammatory-conditions.43555/

Mauritio

@Mauritio said in Niclosamide reduces serotonin and glutamate:

They're catching up! They're using A combo of niclosamide and acetazolamide to treat cancer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10214212/

@cs3000 have you seen this one ?
If I understand correctly they created a new molecule containing both niclosamide and acetazolamide,which has potent anti-tumour effects .

Again it's the combination of an acetazolamide with an mTOR Inhibitor, in this case niclosamide, that has superior effects.
The same was seen in a other study I think you posted, with rapaymcin and acetazolamide.

Mauritio

Inhalable spray-dried dry powders combining ivermectin and niclosamide to inhibit SARS-CoV-2 infection in vitro

https://www.sciencedirect.com/science/article/abs/pii/S0378517325001383

cs3000

@Mauritio amazing result . tho in supp materials didnt show much effect for the lung tumor metastasised for some reason
https://pubmed.ncbi.nlm.nih.gov/27153561/
(increasing apoptosis with the lowered pH from co2, or reversing hypoxia, then inhibiting proliferation further , but not always,
are some exceptions like with certain tumors characterized by poor immune cell infiltration, carbonic anhydrase inhibition doesnt help because even less immune infiltration with the lower pH, but a general approach)

Mauritio

Niclosamide has excellent safety profile. They gave humans up to 1600mg daily and they observed no major side effects.
I'm taking about 50mg .

cs3000

@Mauritio hmm i read a trial where they gave 500mg x3 and had to stop the study because of side effects , but another trial didnt, maybe it was the timeframe not sure but it has some mutagenic effects , those are megadoses tho

low dose orally took out an antibiotic resistant strain of Enterococcus bacteria in mice https://pmc.ncbi.nlm.nih.gov/articles/PMC5988938/figure/F4/

Mauritio

@cs3000 oh what were those side effects ?

Wow, niclosamide night be able to replace the low infrequent antibiotic dose peat recommend and the dosage wasn't even that high. Nice.

bio3nergetic

@Mauritio sorry if I missed it, but where do you get this stuff from?

Mauritio

@bio3nergetic it's OTC in Germany. You can get 4 500mg pills for like 15€ ,which should be enough to try it out. For me that's like 40 dosages so will last quite a while.
It's called yomesan.

bio3nergetic

@Mauritio said in Niclosamide reduces serotonin and glutamate:

yomesan

Thanks, I'll look into US options.

alfredoolivas

@Mauritio You have me curious, have you tried this at all? Edit: You have, did you experience any mental benefits?

Mauritio

@Mauritio said in Niclosamide reduces serotonin and glutamate:

@bio3nergetic it's OTC in Germany. You can get 4 500mg pills for like 15€ ,which should be enough to try it out. For me that's like 40 dosages so will last quite a while.
It's called yomesan.

Inflation is real on this one.
In 2021: 5 tablets 6€
2025: 4 tablets 15€

Had to look up my old post on it lol
Post in thread 'Niclosamide for fat loss/ uncoupling' https://lowtoxinforum.com/threads/niclosamide-for-fat-loss-uncoupling.42781/post-718904

Mauritio

@alfredoolivas yes you can look up my posts on the thread on the rpf on it.
And I still experience increased mood and energy on it. Im figuring out the dosage.
50mg seemed to be too much . 25 too little and today I took 35mg . Which seems to be a good mix.

So 35mg, 1-2/week might be a good protocol.

alfredoolivas

@Mauritio I can't look stuff up on the RPF anymore due to a pay wall :(. Is there a long half life, therefore it should be only taken a few times a week? What were the "too much" symptoms from the 50mg doses?

bio3nergetic

@alfredoolivas Mauritio is referring to this one. I remember I was watching that thread when we were all there.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781/page-6

BTW, no worries about his nonsense paywall. Simply using g00gle with a site exclusive search string (at least g00gle turns out to be good for ONE thing!) You can search for anything on that forum using this method.

Example: Niclosamide site:raypeatforum.com

Yes I also stick it to him by NEVER typing the low toxin blah blah title. That is RAY PEAT'S work he built that forum on. I will always type the old, true name.

And yes, I will never post actual inbound links to that forum. Leaving links only helps "his" forum's ranking.

alfredoolivas

@bio3nergetic thank you, I think it's okay to share the link. its in the name of science