Reversal of hair loss in Mice with “sugar gel”
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@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
NMN
What is NMN? -
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
ethanol
10% propylene glycol
1% NMN
1% Apple polyphenolsIs it reasonable to use a high alcohol content vodka for "ethanol"?
Also, what apple polyphenols product have you been using?
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@AinmBeo you might have to use proportionally more .
I just started using a new one, but it's a German product. Try to find one that has no other ingredients.
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@Mauritio Have you actually gotten all of that to dissolve? I think I would need to prepare two separate solutions in order to get all of those ingredients to dissolve.
NMN is sill pretty expensive if you're buying stuff that's verifiably real.
The dextrose I sometimes spray onto my scalp an hour prior to showering, but I can't handle having it in my hair all day long.
But yeah, I hope you try it out.
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@Gaston Everything but the dextrose, because I don't have it yet.
But it dissolved very easily .True the NMN is still kinda expensive comes down to 15-30€/ month if I calculated it right. But I'll try it out for a while and then decide if it's worth keeping.
I put the new formula on my scalp for 45 minutes today and my hair looked really good afterwards, as if I used a conditioner of something like that. Didn't get this effect with my previous apple polyphenol solution so it must be something from the new formula.
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@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
Interesting. The hair follicle seems to be use mostly aerobic glycolisis for energy production.
"...the hair follicle exhibits aerobic glycolysis, in that of the total glucose utilized by the hair follicle, only 10% is oxidized to CO2."
I couldn't wrap my head around why the hair uses 90-95% aerobic glycolisis for energy , generating large amounts of lactate, even in the presence of oxygen.
From what I've read it has the following reasons:
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Fast ATP generation: hair is one of the most rapidly dividing type of cells in the body . It constantly needs new ATP, which is generated faster by glycolisis . While OxPhos generates more ATP it takes a lot longer and ...
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...Aerobic glycolisis leads to copious amounts of intermediate generation like lactate and pyruvate . Which can be used to build nucleotides and keratin for new hair . In OxPhos the carbon goes towards CO2.
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The hair is a low oxygen environment similarly to tumours thus both use aerobic glycolisis (Warburg effect) l
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Baicalin outperforms Minoxidil in hair growth study .
https://pmc.ncbi.nlm.nih.gov/articles/PMC9699788/#sec3
Here's another in vivo study in which it helps hair growth. Doesn't quite outperform Minoxidil, but results are still decent.
https://pubmed.ncbi.nlm.nih.gov/29336472/
Promotes anagen hair phase in mice.
https://link.springer.com/article/10.1007/s00210-014-1075-0 -
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@Mauritio why do they mess with these mice instead of just recruiting bald people and applying the solution
what purpose does doing this in mice models with relatively safe things like baicalin accomplish
it seems insane -
@wester130 peppermint = bad
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@Mauritio how so?
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@Mauritio might not by systemic with scalp application
