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Reversal of hair loss in Mice with “sugar gel”

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  • M
    Mauritio @Gaston
    last edited by Mar 15, 2025, 7:18 PM

    @Gaston Everything but the dextrose, because I don't have it yet.
    But it dissolved very easily .

    True the NMN is still kinda expensive comes down to 15-30€/ month if I calculated it right. But I'll try it out for a while and then decide if it's worth keeping.

    I put the new formula on my scalp for 45 minutes today and my hair looked really good afterwards, as if I used a conditioner of something like that. Didn't get this effect with my previous apple polyphenol solution so it must be something from the new formula.

    Dare to think.

    My X:
    x.com/Metabolicmonstr

    A 1 Reply Last reply Apr 3, 2025, 1:34 PM Reply Quote 0
    • M
      Mauritio @Mauritio
      last edited by Mar 15, 2025, 8:09 PM

      @Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

      Interesting. The hair follicle seems to be use mostly aerobic glycolisis for energy production.

      "...the hair follicle exhibits aerobic glycolysis, in that of the total glucose utilized by the hair follicle, only 10% is oxidized to CO2."

      https://pubmed.ncbi.nlm.nih.gov/2045676/

      I couldn't wrap my head around why the hair uses 90-95% aerobic glycolisis for energy , generating large amounts of lactate, even in the presence of oxygen.

      From what I've read it has the following reasons:

      1. Fast ATP generation: hair is one of the most rapidly dividing type of cells in the body . It constantly needs new ATP, which is generated faster by glycolisis . While OxPhos generates more ATP it takes a lot longer and ...

      2. ...Aerobic glycolisis leads to copious amounts of intermediate generation like lactate and pyruvate . Which can be used to build nucleotides and keratin for new hair . In OxPhos the carbon goes towards CO2.

      3. The hair is a low oxygen environment similarly to tumours thus both use aerobic glycolisis (Warburg effect) l

      https://onlinelibrary.wiley.com/doi/10.1111/exd.14300

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      C 1 Reply Last reply Apr 6, 2025, 3:32 PM Reply Quote 0
      • M
        Mauritio
        last edited by Mauritio Mar 21, 2025, 4:30 PM Mar 21, 2025, 4:23 PM

        Baicalin outperforms Minoxidil in hair growth study .

        1000013667.png

        https://pmc.ncbi.nlm.nih.gov/articles/PMC9699788/#sec3

        Here's another in vivo study in which it helps hair growth. Doesn't quite outperform Minoxidil, but results are still decent.
        1000013668.jpg

        https://pubmed.ncbi.nlm.nih.gov/29336472/

        Promotes anagen hair phase in mice.
        https://link.springer.com/article/10.1007/s00210-014-1075-0

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        W ? 2 Replies Last reply Mar 21, 2025, 10:27 PM Reply Quote 0
        • W
          wester130 @Mauritio
          last edited by Mar 21, 2025, 10:27 PM

          @Mauritio

          so does peppermint oil

          https://pmc.ncbi.nlm.nih.gov/articles/PMC4289931/

          M 1 Reply Last reply Mar 22, 2025, 7:01 PM Reply Quote 0
          • ?
            A Former User @Mauritio
            last edited by Mar 21, 2025, 10:39 PM

            @Mauritio why do they mess with these mice instead of just recruiting bald people and applying the solution
            what purpose does doing this in mice models with relatively safe things like baicalin accomplish
            it seems insane

            1 Reply Last reply Reply Quote 0
            • M
              Mauritio @wester130
              last edited by Mar 22, 2025, 7:01 PM

              @wester130 peppermint = bad

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              W 1 Reply Last reply Mar 22, 2025, 7:30 PM Reply Quote 0
              • W
                wester130 @Mauritio
                last edited by Mar 22, 2025, 7:30 PM

                @Mauritio how so?

                M 1 Reply Last reply Mar 22, 2025, 7:55 PM Reply Quote 0
                • M
                  Mauritio @wester130
                  last edited by Mar 22, 2025, 7:55 PM

                  @wester130 https://bioenergetic.forum/post/38971

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  W 1 Reply Last reply Mar 22, 2025, 8:11 PM Reply Quote 0
                  • W
                    wester130 @Mauritio
                    last edited by Mar 22, 2025, 8:11 PM

                    @Mauritio might not by systemic with scalp application

                    1 Reply Last reply Reply Quote 0
                    • L
                      LetTheRedeemed @Mauritio
                      last edited by Mar 29, 2025, 7:33 PM

                      @Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

                      @Hando-Jin said in Reversal of hair loss in Mice with “sugar gel”:

                      @Serotoninskeptic

                      "Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."

                      https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat

                      "...excessive glucose is able to increase the expression of hair inductive genes and elongation of hair shaft."
                      https://pmc.ncbi.nlm.nih.gov/articles/PMC7078220/

                      In the above study they used a concentration of 10mM to boost hair growth and mimick excessive glucose . That is just 180mg per 100ml . The issue is that the hair shaft sot relatively deep in the scalp and not much /everything will reach the shaft so to account for the loss i would go for 50mM or approximately 1g or 1% of glucose per 100ml .

                      EDIT : just saw they used d-glucose aka Dextrose . I wanted to use sucrose (table sugar) but I don't think sucrose can substitute as the scalp lacks the enzymes to split up table sugar into glucose and fructose and sucrose is a much bigger molecule, making absorption even trickier

                      On top of that i would use 30% percent alcohol and 10% propylene glycol which sterilize the solution and help absorption and penetration. This is inspired by the formula of Minoxidil, which seems to be absorbed well.

                      So the updated formula would look like this :

                      30% ethanol
                      10% propylene glycol
                      1% NMN
                      1% Apple polyphenols
                      1% of dextrose
                      Rest: Water

                      (add taurine ,caffeine,... to your liking)

                      Total Solids:

                      • Dextrose: 1 g
                      • Apple Peel Polyphenols: 1 g
                      • NMN: 1 g
                      • Total: 3 g

                      Total Liquids:

                      • Water: 70 mL
                      • Ethanol: 20 mL
                      • Propylene Glycol: 10 mL
                      • Total: 100 mL

                      @Gaston

                      Bro that’s a king post

                      M 1 Reply Last reply Mar 30, 2025, 9:59 AM Reply Quote 0
                      • M
                        Mauritio @LetTheRedeemed
                        last edited by Mar 30, 2025, 9:59 AM

                        @LetTheRedeemed thanks 🙏🏻

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        1 Reply Last reply Reply Quote 0
                        • M
                          Mauritio
                          last edited by Mauritio Mar 30, 2025, 10:10 AM Mar 30, 2025, 10:05 AM

                          Update :

                          I had a weird reaction to Propylene glycol. After I added it the formula it gave me estrogenic symptoms like anxiety and puffy
                          face and nipples. I could not find any studies on it being estrogenic , quite the contrary actually . There are some studies showing it might be progestogenic.
                          I have removed it anyways from the formula.

                          I have since then slightly increased ethanol to 35%, to make up for propylene and to increase polyphenols absorption, since they don't dissolve completely.

                          I also noticed that adding sugar makes my hair a little sticky. So I have created a new batch without the sugar as well, only containing NMN, apple polyphenols and ethanol. I can leave this formula in my hair and it looks good, not even a need to rinse it.
                          So it's very practical for every day life .

                          I think I'll make a separate batch including the sugar for maximum effects that I'll use when I don't have to leave the house.

                          I'm thinking about adding biotin to the formula for increased local glyocgen synthesis.

                          Current formula:

                          35% ethanol
                          1% NMN
                          1% Apple polyphenols
                          (1% of dextrose)
                          Rest: Water

                          add taurine ,caffeine,... to your liking

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          A 1 Reply Last reply Mar 30, 2025, 2:00 PM Reply Quote 0
                          • A
                            AinmBeo @Mauritio
                            last edited by Mar 30, 2025, 2:00 PM

                            @Mauritio
                            This is great work.
                            About apple polyphenols:
                            What about using Elderberry extract instead (which I happen to have), which is high in polyphenols like Cyanidin-3-O-glucoside (C3G), which seems to help with hair loss.
                            https://lowtoxinforum.com/threads/cyanidin-3-o-glucoside-c3g-the-next-polyphenolic-star.52555/#post-983384

                            M 1 Reply Last reply Mar 30, 2025, 2:25 PM Reply Quote 0
                            • M
                              Mauritio @AinmBeo
                              last edited by Mar 30, 2025, 2:25 PM

                              @AinmBeo I don't know, wouldn't count on it.
                              Apple polyphenols have humans studies showing their effectiveness, that's why I'm going with them.

                              Dare to think.

                              My X:
                              x.com/Metabolicmonstr

                              A 1 Reply Last reply Mar 30, 2025, 10:25 PM Reply Quote 0
                              • A
                                AinmBeo @Mauritio
                                last edited by Mar 30, 2025, 10:25 PM

                                @Mauritio
                                If NMN is Nicotinamide Mononucleotide, wasn't that banned 3 years ago?
                                I think haidut has said that niacinamide is just as effective as NMN as a NAD precursor.

                                C M 2 Replies Last reply Mar 31, 2025, 12:36 PM Reply Quote 0
                                • C
                                  CrumblingCookie @AinmBeo
                                  last edited by CrumblingCookie Mar 31, 2025, 12:56 PM Mar 31, 2025, 12:36 PM

                                  I've been wondering whether BHB or butyrate would be better energy substrates to hair follices rather than dextrose. I'm thinking preferrably as potassium or magnesium salts.
                                  But alpha-ketoglutaric acid /glutarate may be the energy substrate to prefer (LeeLemonoil had discovered that paper):

                                  Highlights
                                   • mTOR and AMPK modulation by rapamycin, metformin, and a-KG induces anagen hair growth
                                   • Autophagy induction is necessary and sufficient for anagen entry and hair growth
                                   • Autophagy is increased during anagen phase of the natural hair follicle cycle
                                   • Aged mice fed the autophagy-inducing metabolite a-KB are protected from hair loss
                                  
                                  Stimulation of Hair Growth by Small Molecules that Activate Autophagy

                                  It's widely and cheaply available as arginine aKG. I know there are many shampoos etc. with arginine "to promote skin circulation" but not sure if the arginine is a good part. Calcium aKG is difficult and expensive to get and I reckon the calcium is disadvantageous in the skin.
                                  Pure aKG (free acid) is even more difficult to get thatn Ca-aKG. So perhaps the AAKG is good.
                                  a-KB is alpha-ketobutyrate. Which I can't find listed for sale anywhere but it surely looks great for hair.
                                  aKG hairloss mice.jpg

                                  M H GastonG 4 Replies Last reply Mar 31, 2025, 7:02 PM Reply Quote 0
                                  • M
                                    Mauritio @AinmBeo
                                    last edited by Mar 31, 2025, 6:06 PM

                                    @AinmBeo you can still buy the exact same stuff. It's just labeled as research chemical. Similarly to idealabs.

                                    Somebody else posted a study (I reposted it somewhere too) that Niacinamide did NOT have beneficial effects on hair health.
                                    Based on other studies Im starting to think that they're not interchangable when it comes to all effects. I think they both have benefits though .

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    A 1 Reply Last reply Mar 31, 2025, 6:10 PM Reply Quote 0
                                    • A
                                      AinmBeo @Mauritio
                                      last edited by Mar 31, 2025, 6:10 PM

                                      @Mauritio I do not see NMN for sale anywhere on amazon. We do not have access to the labs that only sell to folks like Haidut.

                                      alfredoolivasA 1 Reply Last reply Mar 31, 2025, 6:29 PM Reply Quote 0
                                      • alfredoolivasA
                                        alfredoolivas @AinmBeo
                                        last edited by Mar 31, 2025, 6:29 PM

                                        @AinmBeo These "labs" don't tend sell on amazon, even though some do.

                                        They aren't really "labs", they are just resellers of "research" wink, wink chemicals

                                        1 Reply Last reply Reply Quote 0
                                        • M
                                          Mauritio @CrumblingCookie
                                          last edited by Mauritio Mar 31, 2025, 7:03 PM Mar 31, 2025, 7:02 PM

                                          @CrumblingCookie
                                          Great points !

                                          Butyrate could indeed feed the TCA cycle and increase scalp ATP.
                                          It's a small molecule and very water soluble so it should be possible to add it to my formula.

                                          I found an in vitro study that directly corroborates what you said :

                                          • Butyrate delays catagen phase in hair follicles
                                          • Increases autophagy
                                          • "...may be exploited to promote human HF growth, metabolism, pigmentation and/or antimicrobial defences."
                                            https://www.morressier.com/o/event/62d558b38a1a1f00195adc16/article/62fa00a7cf455b001a73dd1e

                                          Here's another study showing sodium butyrate increases autophagy and inhibits mTOR.
                                          https://pubmed.ncbi.nlm.nih.gov/37686278/

                                          Since these beneficial effects seem to depend on the AMPK-mTOR-autophagy axis that might explain biotin's strong anecdotal evidence for helping hair.
                                          Biotin increases AMPK and thus inhibits mTOR and induces autophagy.

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          C 1 Reply Last reply Mar 31, 2025, 7:55 PM Reply Quote 0
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