Progest E Love Thread
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@brad i was referring to the anti-androgenic effects of large doses of prog in males like loss of libido, penis numbness, sensitive nipples etc.
These higher doses "compete" for 5α-reductase to form 5a-DHP, so conversion of T to DHT through that enzyme would be reduced hence the anti-androgenic effects.
A little bit of dhea can help you get away with high doses of prog without these effects, probably as dhea will be favoring the T pathway as opposed to the estrogen one.This is all in theory of course, but im going to soon try progest e with dhea in a 3:1 ratio in high-ish doses for anti-catabolic/anabolic effects and will make a seperate post about it.
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@brad Thinking about giving Progest-E a shot. Whats the protocol look like? Positives and negatives of taking? Any risks?
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@Hitler It depends what you're hoping to address in particular. Would recommend you read this article by Ray.
Some Effects of Progesterone in Men Copyright 2021 - Ray Peat, PhD
Classifying progesterone as a “pregnancy hormone” and a “female sex hormone” has seriously limited understanding of its function in both men and women. It is a stabilizer of cellular structure and function in all organs, similarly in men and women. This stabilizing effect is especially important in the nervous system, where it is protective against stress. In both men and women, a progesterone deficiency is associated with problems including seizures and bipolar disorder, irritability/elation, aggression, and depression, as well as sex-related problems.
In the 1970s, an acquaintance told me that he had become impotent following his vasectomy. I was familiar with the progesterone deficiency produced in women by tubal ligation and by intrauterine contraceptive devices, and I had seen a study of men’s hormones following a vasectomy, in which an isolated deficiency of progesterone sometimes occurred, so he decided to try some progesterone. He later said that a single dose had corrected his erectile problem. Other young men with erectile dysfunction, from other causes, had similarly good results with small amounts of progesterone.
When a problem is quickly and permanently corrected with a small amount of progesterone it seems likely that the progesterone acted in the brain to shift the balance, maintained by endorphins, away from the stress induced inhibition of progesterone and testosterone synthesis. At the same time, though, that progesterone is lowering cortisol, it is also reducing inflammation, partly by acting as an antagonist to aldosterone. Increased aldosterone is associated with erectile dysfunction (Chang, et al., 2019; Wu, et al., 2018, 2016), and it interacts locally as a testosterone antagonist. In this, and other situations involving testosterone antagonists (estrogen, cortisol, aldosterone), progesterone can have a directly testosterone- supporting effect.
After the age of 35 or 40, many men experience a decline in their resistance to stress, corresponding to the decline in protective substances such as DHEA and progesterone. Often a small amount of progesterone, 5 or 6 mg (for example, a drop of Progest-E the size of an unpopped kernel of popcorn) can make a difference, sometimes lasting for a few days or more. Paying close attention, the effects are usually noticeable within about half an hour. At a certain level, progesterone can antagonize the effects of testosterone; in younger men, 2 or 3 drops can have that effect. That effect passes within a day of stopping the progesterone. If a younger man uses progesterone topically, for example for sunburn, a little olive oil should be applied to the skin first to make it spread easily; if it’s used on a large area, the same anti- testosterone effect is likely to be noticed.
REFERENCES
Surgery. 2019 Mar;165(3):622-628. Risk of severe erectile dysfunction in primary hyperaldosteronism: A population-based propensity score matching cohort study. Chia-Hui Chang, Shih-Chieh J Chueh, Vin-Cent Wu, Likwang Chen, Yen-Hung Lin, Ya-Hui Hu, Kwan-Dun Wu, Yao- Chou Tsai.
Asian J Androl. Jan-Feb 2018;20(1):24-29. Aldosterone induces inflammatory cytokines in penile corpus cavernosum by activating the NF-κB pathway. Fei > Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji- Meng Hu , Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding.
World J Urol. 2016 Jul;34(7):999-1007. Elevated plasma aldosterone is an independent risk factor for erectile dysfunction in men. Fei Wu, Shanhua Mao, Tianfang Yu, Haowen Jiang, Qiang Ding, Gang Xu.
Endocrine. 2018 Sep;61(3):372-382. The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction. Fei Wu, Yun Lin, Qingyong Liu. -
@brad Thank you! I'm just wondering, where did you find this article? I looked it up and couldn't find it anywhere, and it wasen't on Chadnet or anything.
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Besides progest e just generally making me.feel warm and fuzzy like sitting in a sunset talking to friends, I have found it to instantly stop the pain from a burn (i.e. 500 degrees Celsius from an oven) and be really helpful for the healing.
Also was extremely helpful when I had a fever last year and felt impending doom/incredible dread on its onset and had an oral temperature of over 39°C. Immediately made all uneasiness evaporate and I slept very well. -
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@ATP thats just a meme
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How to get it in EU? customs fucks me over if I try to order anything from outside.
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@brad Can you get it shipped to the EU? I am worried about losing it to the customs.
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I would also be interested to know if someone has ever gotten it into the EU.
Would like to try it on my shoulder and upper back.
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@brad
Are you needing to heat the progest-e to get the dhea incorporated?I am thinking to add appropriate amount to entire bottle of progest-e for my dad, and then have him put olive oil on skin and then spread progest-e mixture.
Or do you think the olive oil needs to be mixed in with the dhea/progest-e?
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Curious how the mere mention of this always summons a horde of weirdly inconsistent nightmare stories and retards. Odd how that be
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@brad I will try this salve once I can order.
I fractured my scaphoid bone in both of my wrists, they consolidated well but I didn't do any surgery. I had a cast on my right arm for the whole summer. Not on the left one and it healed faster... Anyway, I still have a bit of pain during workouts 1 year after in the scaphoid zone so maybe this salve would help -
Progest-E never seemed to give me any noticeable reactions, good or bad, as a man in my early 20s. Aspirin gives me much greater benefits.
