Reversal of hair loss in Mice with “sugar gel”
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I found this thread talking about it, from a podcast/conversation with Ray Peat and Danny Roddy titled
"Lost Conversations with Ray Peat #1: The Purpose of Hair, Luciferianism, and Obama as a CIA CreationLooks like that episode has been nuked off the internet by the censors. Probably for that title and the discussion content.
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@Hearthfire brooo you came thru king.
I'm thinking a topical spray of glucose + a pro-energy substance like t3/niacinamide/aspirin!
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@ThinPicking right? Now I'm even more excited to try Ray's suggestion of topical glucose.
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@Mauritio
You said this in the old rpf thread above:Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)
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@LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:
@Mauritio
You said this in the old rpf thread above:Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)
It definitely helps . But I switched to using Apple juice because, it has sugar as well and because of the polyphenol content. Actually I dissolved a full capsule of swansons apple polyphenols in a bit of juice and applied it to my scalp . It really made a difference , but it was such a mess to apply that I stopped.
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@Mauritio gotcha. Thanks for sharing
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a month ago someone mentioned topical ribose completely unconnected to this study though
https://old.reddit.com/r/raypeat/comments/1dlavfd/baldness_is_insulin_resistance_metformin_is/
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@wester130 nice, thanks for sharing
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@Amazoniac Yo brotha.
Do you have any thoughts on d-ribose supplementation? Could it have negative repercussions?
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From what I can remember in posting about it on the Ray Peat Forum, supplementation is safe. In support:
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@Amazoniac ah ok… thanks so much for the info
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@LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:
EDIT: "it increases NO [nitric oxide is bad for metabolism] so according to danny roddy it is le bad." - sneedful
Any references indicating this to be true or false would be appreciated.This review warns against high doses of D-ribose:
https://www.spandidos-publications.com/10.3892/etm.2021.9927"In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means. D-ribose may glycosylate insulin to form ribosyl insulin, activate Caspase-9 and -3/-7, trigger transcription factor NF-κB and produce intracellular reactive oxygen species (ROS) that may cause cytotoxic damage to the surrounding tissues and cells, eventually leading to the manifestation of chronic complications (63)."
So, I suppose, D-ribose may increase inducible NO (iNOS) by way of triggering NF-kappaB, which is a primary inflammatory response (see, e.g., pubmed here)
Personally, i will avoid supplementing with D-ribose due to a possible NF-kappaB trigger, even not being a diabetic.
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there is a thread about nad+ in the other forum and some researcher posted there that he uses b3 in combination with d-ribose in his patients ...
i would assume he can say more about it.
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FYI, d-ribose and deoxyribose are not the same thing.
https://commonchemistry.cas.org/detail?cas_rn=533-67-5
https://commonchemistry.cas.org/detail?cas_rn=50-69-1 -
@LetTheRedeemed The nitric oxide thing might explain why it works--NO is said to be what makes minoxidil work.
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@OliverCloasov no im not saying he said this particular thing i am making fun of danny’s reductionist midwit bullshit
i dont know or care about what danny has to say about this particular substance.
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@sneedful ah yes, the estrogen-cascade-blood-vessel-dilation theory of life. Danny's on the nose about the toxicity of NO.
https://raypeat.com/articles/articles/dark-side-of-stress-learned-helplessness.shtml
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@Cicero said in Reversal of hair loss in Mice with “sugar gel”:
FYI, d-ribose and deoxyribose are not the same thing.
https://commonchemistry.cas.org/detail?cas_rn=533-67-5
https://commonchemistry.cas.org/detail?cas_rn=50-69-1Thanks, I know. They are different stages of the conversion of glucose toward atp.
Ray was a proponent of even putting sugar on the scalp, so my thought is that any step closer may provide additional benefits.
we can disregard sneedful's comments as he is noncontributory
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@Ben thanks!
any chance you have a link? I'd be grateful if you shared! I don't have accounts in any other forum.
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Wild idea here, but building on the topical sugar idea, any thoughts on mixing a target sugar with DMSO for topical use? I ask due to DMSO's penetrative boosting capability
