Thymus health

Lejeboca

This got me thinking that, since our endogenous CORT is "naturally" elevated in the morning, if we have an LPS-prone breakfast, then any existing inflammation will spike.
So

rule #1, breakfast that is easy on digestion (Ray-Peat-right-again!)
At breakfast time consider
charcoal or anything digestion-promoting
getting red/sun light at breakfast time to to decrease NO and other inflammatory cascade factors.

DavidPS

The gut microbiome and the intestinal barrier are involved as well.

Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing (2024)

albion

Anyone tried thymus extract / Thymosin? Some studies showed strong anabolic and immune-promoting effects; it seems to have been a popular "pharmaceutical" treatment back when doctors had spines (and functioning thymus glands?!)

LucH

@DavidPS said in Thymus health:

I am waiting for the results of the TRIIM-X trial (Thymus Regeneration, Immunorestoration and Insulin Mitigation) mentioned in this paper.

When there is a lack of T cells in the body, it can lead to immunodeficiency diseases. Your thymus is the source of new T-cell specificities that fight infections, autoimmune cells and cancer.
This to make the junction with mTOR pathway.
Regulation of T-cells by m-TOR
doi: 10.1016/j.it.2014.11.005
How does mTOR affect T cells?
Overall, by functioning as a central hub that coordinates multiple signaling pathways, mTOR plays a critical role in regulating various aspects of T-cell function, including T-cell development, activation, differentiation, migration, survival, memory formation, and exhaustion.
I can develop but it's going to be a bit too long ...
Well, without giving the details, I use H3CO2 (bicarbonate 2 g) to reset the system from time to time (seasonal).
In the case of chronic inflammation, induced by overexpression of the immune system, the researchers found that the ingestion of H3CO2 (2 g bicarbonate) made it possible to restore normal Treg function so that these cells can do their job(s), and temper self-reactive T cells that attack one's own organs in autoimmune diseases.
NB: In cure, of course. Do not stay too long in M2 mode. Alternate balance is required.
I can develop but not in this post. Too long and I don't want interferences with the_one_I_can_not_mention_the_name

DavidPS

@LucH - I will try using H3CO2 to reset my system.

T-3

@LucH said in Thymus health:

M2 mode

What does "M2 mode" refer to?

yerrag

@Lejeboca said in Thymus health:

This got me thinking that, since our endogenous CORT is "naturally" elevated in the morning, if we have an LPS-prone breakfast, then any existing inflammation will spike.
So

rule #1, breakfast that is easy on digestion (Ray-Peat-right-again!)
At breakfast time consider

charcoal or anything digestion-promoting

getting red/sun light at breakfast time to to decrease NO and other inflammatory cascade factors.

Thanks. What would tou consider to be an LPS-prone breakfast? Is it a soluble fiber-rich breakfast, one that includes substances that kill bacteria and thus produce LPS remnants of bacteria? What are some noteworthy examples of such a breakfast?

LucH

@T-3 said in Thymus health:

What does "M2 mode" refer to?

Repolarization of macrophages M1 <> M2
Lymphocyte T polarization
In an (over-simplified) model, the Th1/Th2 and M1/M2 ratios (M=macrophages) can thus be used as indicators to determine whether or not the immune system is in M1/inhibitory type mode, oriented towards host defense, or in an M2/healing type mode, oriented towards the repair and replacement of lost or defective tissues with a view to maintaining host homeostasis. (Mills 2015a).
(doi: 10.3389/fimmu.2015.00059)
Vocabulary:
M stands for macrophage
Th stands for thymus. Th1 = T helper cell type 1, produced by thymus. = lymphocyte, a type of white blood cell.

There are two major types of T cells: the helper T cell and the cytotoxic T cell. As the names suggest helper T cells 'help' other cells of the immune system, whilst cytotoxic T cells kill virally infected cells and tumors.
Treg cells
Regulatory T cells, or Tregs, are white blood cells that play a key role in regulating your immune system. Tregs control your body's immune response to keep it from over-reacting to harmful invaders known as antigens. Antigens are frequently unwelcome substances that cause an immune response in your body.

Understanding macrophage cells and the balance to find between M1 & M2, inducing a TH1 or Th2 answer (by Treg cells). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329822/

Lejeboca

@yerrag said in Thymus health:

What would tou consider to be an LPS-prone breakfast? Is it a soluble fiber-rich breakfast, one that includes substances that kill bacteria and thus produce LPS remnants of bacteria? What are some noteworthy examples of such a breakfast?

Oops. Missed your question, almost a year-old by now.
I'd say, anything that will sit/rot in your stomach long to let bacteria rejoice and produce LPS.
In my past life, I used to have beans for breakfast when travelling in Ireland.

Lejeboca

A hormonal take on thymus:

Estrogen Blocks Early T Cell Development in the Thymus

From RESULTS:

Estrogen treatment caused a dramatic reduction in thymic size and cellularity. Implantation of slow release estradiol and estriol pellets lead to a marked reduction in total thymic cell recovery after 2 weeks.
Progesterone alone had no effect on thymic cell counts, while progesterone when given with estrogen had a synergistic effect.
We did not observe any significant difference in the total cell recovery between
control sham operated and ovariectomized mice ([part of] Table I):

From DISCUSSION:

Estrogens probably affect the thymocytes both directly via estrogen receptors and indirectly by causing a reduction in the bone marrow precursor cells. Estrogen and progesterone receptors have been identified in thymic tissue [5-7], supporting the concept that sex hormones can regulate immune function through the thymus.

yerrag

@Lejeboca Thanks. Much in line with what we think of soluble fiber rich foods. Makes me think of going back to juicing, as that takes a lot of soluble fiber out of eating fruits, which while potassium rich almost always, if not always, comes with the baggage of soluble fiber.