Posts made by Peatly

@Wkia said in Supplementing T3 not safe afterall?:

Hi, I'm new here and hoping that maybe I can ask about a study that I stumbled upon but have no acces to. Maybe someone else has.

Recently, after reading a lot about thyroid on another forum, I started to take T3 next to the levothyroxine which I have been taking as long as I remember because of hypothyroidism. It went really well, lot's of new energy and temperature went up so that made me really happy.
Maybe I should have stopped googling and reading about the subject then but I did'nt and so I stumbled upon this study from december 2022:

'Heart Failure and Stroke Risks in Users of Liothyronine With or Without Levothyroxine Compared with Levothyroxine Alone: A Propensity Score-Matched Analysis'.
https://pubmed.ncbi.nlm.nih.gov/35570696/#:~:text=In addition%2C the risk of,and history of thyroid cancer.

It's about 1434 T3 users (with or without T4) compared to 3908 LT4-only users.
It says that he risk of heart failure and the risk of stroke are considerably higher after T3 therapy.

Can anyone tell how seriously this study should be taken?
I'm a bit worried now...

Wasn’t this during the height of “died suddenly” when studies were appearing to explain away why people were having heart attacks?

Also this study was in thyroid cancer patients who probably couldn’t meet the increased dietary requirements to support t3 supplementation. Dr Peat has said that too much thyroid can enlarge the heart (see Thyroid: Misconceptions newsletter).

It didn’t end well for Madalyn Murray O'Hair

modules:composer.user-said-in, @peatyourmeat, Why is the Ray Peat community so far right?

@Norwegian-Mugabe

won this thread

Thanks for letting me know. I didn’t realise it was a competition. What prize did he win?

Good question – been thinking about this lately as I too would like to know my pufa status. I came across this article when I was looking. The article explains some of challenges of testing and what to look for.

Metabolic indices of polyunsaturated fatty acids: current evidence, research controversies, and clinical utility

Traditionally Africans (like all groups) had good microbiome because their diets contain fewer or no processed foods. However, now that they have been sold progress, along with “democracy” and liquid oils, they are in equally poor state as Westerners. Mass poisoning with vaccines and other drugs is probably contributing to food allergies as observed in Western countries.

Milk containing vaccines cause milk allergies, EoE, autism and type 1 diabetes

Evidence that food proteins in vaccines cause the development of food allergies and its implications for vaccine policy

Dr Peat talking about the low incidence of bowel and liver cancer in Africans

“Dennis Burkett, who sort of started the fiber fad about 30 years ago, when he discovered that Africans didn't have a very high incidence of bowel and liver cancer and that they tended to have three bowel movements per day, where Americans are more likely to have one or fewer.” Ray Peat

Lactose digestion depends on the presence of the enzyme lactase-phlorizin hydrolase; if milk is not incorporated into the diet the enzyme is not made by the body. Once milk consumption is introduced it can take weeks for the enzyme to be produced – meanwhile symptoms of lactose intolerance will be present until that time.

Not all Africans are lactose intolerance (Africa is a continent not a country)

https://en.wikipedia.org/wiki/Lactase_persistence

High frequencies of lactase persistence are also found in some places in Sub-Saharan Africa and in the Middle East. But the most common situation is intermediate to low lactase persistence: intermediate (11 to 32%) in Central Asia,[7] low (<=5%) in Native Americans, East Asians, most Chinese populations[2] and some African populations.[3][4][7]

In Africa, the distribution of lactase persistence is "patchy":[8][9][3] high variations of frequency are observed in neighbouring populations, for example between Beja and Nilotes from Sudan.[10] This makes the study of lactase persistence distribution more difficult.[4] High percentages of lactase persistence phenotype are found in traditionally pastoralist populations like Fulani and Bedouins.[3][11]

Lactase persistence is prevalent in Nguni and certain other pastoralist populations of South Africa as a result of the dairy they consume in their diet. Lactase persistence amongst Nguni people is, however, less common than in Northern European populations because traditionally, their consumption of dairy came primarily in the form of amasi (known as Maas in Afrikaans), which is lower in lactose than fresh, raw milk as a result of the fermentation process it goes through.[12][13][11][14][15][16][17][18][19]

Dr Peat’s article on milk

@Mauritio said in Vitamin A quotes from Ray's favorite physiology book:

@Peatly said in Vitamin A quotes from Ray's favorite physiology book:

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

Yes, I agree.
What does it have to do with the sun/ Vitamin D?

I was under the impression that being exposed to sunlight, for extended periods, increases your vitamin A requirements. I was thinking that if the sun is being blocked this might lower need?

Dr Peat talking about light exposure and vitamin A

This is the dentist Dr Peat mentions in that clip
Emanuel Cheraskin, M.D., D.M.D., late Professor of Oral Medicine at the University of Birmingham, AL.

The "ideal" daily vitamin A intake

Relationship of vitamin A and oral leukoplakia

The meme King is amongst us – rejoice!!!

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

“About 40 years ago, three different doctors diagnosed, told me that I should have a biopsy on three different things. And since I had already been studying what doctors do and know about cancer, I ignored them and increased my thyroid and used a little nutritional addition like extra vitamin A and folic acid. I put some progesterone and DHEA on the area. And so far, that's 40 years ago, and none of them have persisted.” Ray Peat

@Norwegian-Mugabe said in Why is the Ray Peat community so far right?:

@Aryan_Racist Lol, leftist are the filth of the earth. Their looks always gives them away. I hope Trump deports 30 millions.

@Peatly lol, you make it sound like we should welcome revenge because we have been dominating throughout history. I am super proud that our national wealth fund steals the surplus value of apefreakian labour. I hope we will colonize more in the future. The Aryan supremacy has just begun. I gave an immigrant woman PSTD while having fun playing games. Things are only getting better for us as we stand before a new dawn of an eugenic supercycle. Another white boy summer is incoming.

Nothing in Ray Peat’s work supports your ideology, nor does Christian teachings. In case you are not aware, the far right extremism narrative is being hyped up at the moment. Some of your posts are so outrageous it makes me wonder if you are deliberating drawing attention to yourself for the purpose of associating Ray’s name with your political views. As much as I support your right to free speech, please do not do it in Ray Peat’s name. You’ve admitted to committing a crime by harming a migrant woman. Why would you brag about this? All you are doing is providing evidence to support the potential take down of this forum. It’s plausible that’s your objective.

“If something is driving your aldosterone abnormally high, such as a deficiency of progesterone, then the combination of high aldosterone and high salt intake will increase your blood pressure. But when your thyroid and vitamin D and calcium intake are good, that will hold down your aldosterone and progesterone antagonizes the effects of aldosterone. So that combination of vitamin D, calcium, thyroid and progesterone are the basic anti-aldosterone system and the blood pressure regulating system apart from sodium.” Ray Peat

Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy

SOME CONTEXTS
In biology and biochemistry, calcium is the substance most often studied, so it is significant that researchers still speak of a calcium paradox.

There are several such paradoxes: As bones lose calcium, the soft tissues calcify; when less calcium is eaten, blood calcium may increase, along with calcium in many organs and tissues; if an organ such as the heart is deprived of calcium for a short time, its cells lose their ability to respond normally to calcium, and instead they take up a large, toxic amount of calcium.

Magnesium deficiency and calcium deficiency have some similar symptoms (such as cramping), but magnesium is antagonistic to calcium in many systems. It is the basic protective calcium blocker.
Inflammation leads to excessive uptake of calcium by cells, and is a factor in obesity, depression, and the degenerative diseases.

Protein deficiency is an important cause of deranged calcium metabolism. Vitamins K, E, and A are important in regulating calcium metabolism, and preventing osteoporosis. Aspirin (with antiestrogenic and vitamin E-like actions) is protective against bone resorption and hypercalcemia.

@Orindere said in Why is the Ray Peat community so far right?:

I think that being highly argumentative isn't peaty

On the contrary Dr. Peat was incredibly argumentative. Of course, in ways that were productive.

@Mauritio Well, I'm not sure. It does seem to modulate the thyroid but not in the way I had previously understood it. I’m yet to understand the full mechanism by which thyroid deficiency may warrant more vitamin A but I am reading and hope to report back.

The relationship between thyroid disorders and vitamin A.: A narrative minireview

From the article

“Retinoid nutritional status is able to modulate thyroid gland homeostasis. Vitamin A deficiency (VAD) appears to be closely related to thyroid gland impairment, due also to its frequent association with iodine deficiency (ID) (3, 4, 6, 10). Indeed, retinoids seem to play a role in the development and maturation of the thyroid cell phenotype (4).”

“Several animal studies using mouse models have shown that VAD is related to reduced iodine uptake, impaired coupling of iodothyronines, and reduced thyroglobulin synthesis, which can lead to thyroid hypertrophy and goiter and to a decreased intrathyroidal pool of T3 and T4 (10–15). The hypothesis that vitamin A deficiency, in the presence of protein-calorie malnutrition, might impair the glycosylation of thyroglobulin (Tg) was proposed by Ingenbleek Y in 1983 (12).”

“A relatively recent Iranian study by Farhangi et al. observed that, in healthy premenopausal obese and non-obese women, 4 months of VAS was able to reduce TSH and increase T3 levels (possibly due to a hepatic effect on the conversion of thyroid hormones), reducing the risk of subclinical thyroid dysfunction (32).”

For some reason I can't find that first quote in the Constance R. Martin book

@Norwegian-Mugabe Well, this is not the response I was expecting from someone with high IQ. You bypassed intellect and went straight to a primal reaction.

BTW your country played a role in people trafficking which is contributing to the present situation. Not to mention the many ways the powers that be have colluded to displace people and steal their resources.

David Webb had something to say about rich people being protected. When the time comes I hope your “high IQ” will shield you.

@Jakeandpace Thank you for reading. The study concludes:
Vitamin A metabolism and cholestatic disorders are connected in a certain way, since vitamin A deficiency in chronic cholestatic diseases may be not only a reflection of reduced gastrointestinal absorption of fat-soluble vitamins, but it also could be involved in the pathological mechanisms underlying these diseases. In cholangiopathies, retinoids exert their potentially beneficial effect through different mechanisms: repression and prevention of hepatic fibrosis after liver injury through the inhibition of Ito cell transformation into myofibroblasts, modulation of the immunological response to hepatic damage through the regulation of expansion and apoptosis of myeloid cells, and the reduction of the toxicity of cholestasis through the inhibition of bile salt synthesis. More research is needed on hepatic retinoid levels of patients with chronic cholestatic diseases. Also, different retinoids and application forms may exert different effects and have yet to be investigated, including potential severe adverse effects. However, atRA may be a promising new agent in the therapy of chronic cholestatic disorders.

atRA (all-trans retinoic acid)

@Norwegian-Mugabe said in Why is the Ray Peat community so far right?:

@CO3 I have better health than you. I am extremely strong and have a high temperature. My squat sets are now well into the 200s. I never think of these things on a day-to-day basis. The shopping mall got me into a healthy rage. That being said, it would be totally unhealthy to think it is acceptable that 12% of children are born to single mothers, or that outbreed depression is acceptable. Everything I wrote was correct, even though it is best to avoid the masses and avoid thinking about these things. I am very fortunate to work with a high IQ homoethnic group of wealthy coworkers. I am shielded from average people for most of my life. I am happy with my life, but our society as a whole is literally doomed. You are correct though that our health changes how we view these things. I was angry at the decline a few years ago. Now I laugh at it.

This insularity is hardly conducive to maintaining a high IQ. Wouldn’t exposing yourself to a variety of experiences enhance your intellect?

Thank you @Mauritio

I'm really surprised at that first quote because I was under the impression that hypothyroidism decreases the vitamin A requirement. Do you have the page number for that quote please.

I came across this article recently - vitamin A deficiency is no small thing

Vitamin A deficiency in chronic cholestatic liver disease: Is vitamin A therapy beneficial?

Yes, I’ve noticed that calcium, along with vitamin D, are also being vilified over there. The doctor that Dr. Peat regularly cited in relation to the “sodium cause hypertension debate” is David A. McCarron – (Division of Nephrology, Hypertension, and Clinical Pharmacology, Department of Medicine, Oregon Health Sciences University). He showed that low calcium was responsible for the hypertension being blamed on sodium. This review article goes into detail.

The thing about calcium is that the body has ample reserves (bones) to draw on during periods of deficiency - then one day you have osteoporosis. For the past few years I am noticing more on more women (relatively young) with walking sticks.

Have you tried high dose thiamine? – flagyl (Metronidazole) can cause mitochondrial dysfunction and disturb thiamine metabolism.

Some articles that explain the mechanisms of injury

Cipro and Flagyl Neurotoxicity in Brazilian Jiu Jitsu Athlete

Metronidazole: The New Mitochondrial Nightmare

Metronidazole Toxicity and Doctor Denial

Metronidazole Toxicity, Thiamine Deficiency, and Wernicke’s Encephalopathy