Topics created by stag

@stag

I wonder if their theories can be shown on blood tests.
Although I know how Dr. Peat feels about free T4 and free T3 labs, an rT3 might be good to track in such cases.

My rT3 indeed does go down when I increase my T3 while taking T4/T3.

Thank you for sharing this - I will look into their therapies further.

@LucH That's a very comprehensive paper, thanks for sharing!

I didn't mean that zonulin is a protective inhibitor, I was referencing that substances that inhibit zonulin (like Larazotide acetate) are protective against its deleterious effects (like type 1 diabetes / celiac), as elaborated on in the papers we have both posted.

@LucH said in Zonulin and its Consequences:

For me zonulin is secreted in presence of excess lectins and gliadin (agglutinin family) to avoid aggregation with L-glutamine from the membranes. Zonulin acts as a garde-barrière, telling the body to let the toxins get away. Zonulin tells the tight junctions to stay open …

Do you have more info on this? A search for lectins and leaky gut discloses this article:
Lectins: The Gluten-Lectin-Leaky Gut Connection

Some lectins that we consume in everyday foods can bind to the sugars in the cell walls of the gut or in the blood. This can cause an immune response, leading to inflammation, intestinal damage, altered gut flora, malabsorption, decreased cellular repair, cellular death, and eventually disease.

These lectins bind to glycoproteins and glycolipids (sugar-coated proteins and fats) found on the surface of human and other animal cells. This binding allows for agglutination (clumping) and sometimes can produce an immune response. They can cause agglutination of blood cells and they can bind to the cells that line the small intestine.

This article also references Fasano, he seems to be a popular guy in zonulin world. The relevant reference regarding lectins is here (I think):
Dietary lectins are metabolic signals for the gut and modulate immune and hormone functions

A related paper is here:
Characteristics and consequences of interactions of lectins with the intestinal mucosa

Following general Peat diet suggestions will have you avoiding most lectin-containing foods anyway, but there are two that stick out: dairy and nightshades. Someone could be getting most of their calories from milk and potatoes thinking theyre fine because its Peaty but may be driving intestinal permeability due to the lectin content.

The example given in the article of a noxious lectin is wheat germ agglutinin. I wonder how bad non-wheat derived lectins like those from potatoes and milk are.

If the mechanism is as described I also wonder if it may be advisable to keep dietary gluten and lectins to a minimum during L-glutamine supplementation, as that combination may provide ample reason for a zonulin trigger. This will be easy for wheat, likely also potatoes, but cutting milk may prove to be a challenge, if necessary. It also may be the case that the supraphysiological doses of glutamine generally used in supplementation may override any zonulin signaling caused by incidental dietary lectins. I'm not sure.

@stag thank you so much for this, I always wanted to read this study fully, much appreciated 🙏

Have you had additional gout flareups since this time, or do you believe you've found a permanent solution for them?

I never suffered gout until I began Peating, but I suspect it's because I didn't consistently incorporate the fiber sources Ray recommends (raw carrots/boiled mushrooms/bamboo shoots) into my diet. This may have left me unable to properly flush endotoxins, and resulted in my gout flare up.

Anyway, I'm in the middle of my second flare up now, and committed to incorporating more fiber in my diet going forward, but I'm still looking for help dealing with the immediate debilitating pain.

@Ecstatic_Hamster tried them a few years ago and never received it. Maybe I'll give it another shot. Thanks.

@skylark said in Warm tone light mode for pdfs:

boox note air

that looks so cool

Here Peat talks about atropine / jimson weed, aka Datura stramonium, infamous for its hallucinogenic and intoxicating properties, but medicinal in this context:

"...the medical standard for a long time was to use muscle relaxant like atropine or jimson weed to relax the duct out of the gallbladder and then take olive oil to stimulate the contraction"

"But is there something, what did you say, Doc, you do before the gallbladder flush that is good to do to relax the muscles around the gallbladder?

The jimson weed. It works like atropine, very similar chemical. And that 50 to 100 years ago was recognized as very effective and safe, but the atropine, partly because drug culture used it for entertainment, it lost a lot of its medical use [...] A piece of leaf the size of your thumbnail sometimes was enough"

bioenergetic:life: 05.16.22 PEAT RAY

@stag What would u do to cope with dirty elektricity?