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    Reversal of hair loss in Mice with “sugar gel”

    Literature Review
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    • L
      LetTheRedeemed @A Former User
      last edited by

      @sneedful dangit. in that case it could be working on hair growth thru the estrogen function: increase water retention, ie bloodflow

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      • L
        LetTheRedeemed
        last edited by

        Anybody recall Peat's quote on sugar helping hair growth? was he talking topical? I wonder what topical glucose + ATP + Progest E might do.

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        • B
          bot-mod
          last edited by

          This is so simple I could believe in it.

          Thanks for sharing it.

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          • H
            Hearthfire @LetTheRedeemed
            last edited by

            @LetTheRedeemed

            I found this thread talking about it, from a podcast/conversation with Ray Peat and Danny Roddy titled
            "Lost Conversations with Ray Peat #1: The Purpose of Hair, Luciferianism, and Obama as a CIA Creation​

            https://raypeatforum.com/community/threads/did-ray-peat-just-recommended-topical-honey-for-hair.50151/

            Looks like that episode has been nuked off the internet by the censors. Probably for that title and the discussion content.

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            • L
              LetTheRedeemed @Hearthfire
              last edited by

              @Hearthfire brooo you came thru king.

              I'm thinking a topical spray of glucose + a pro-energy substance like t3/niacinamide/aspirin!

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              • L
                LetTheRedeemed @bot-mod
                last edited by

                @ThinPicking right? Now I'm even more excited to try Ray's suggestion of topical glucose.

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                • L
                  LetTheRedeemed
                  last edited by

                  @Mauritio
                  You said this in the old rpf thread above:

                  Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                  I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                  With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                  Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                  MauritioM 1 Reply Last reply Reply Quote 0
                  • MauritioM
                    Mauritio @LetTheRedeemed
                    last edited by

                    @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                    @Mauritio
                    You said this in the old rpf thread above:

                    Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                    I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                    With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                    Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                    It definitely helps . But I switched to using Apple juice because, it has sugar as well and because of the polyphenol content. Actually I dissolved a full capsule of swansons apple polyphenols in a bit of juice and applied it to my scalp . It really made a difference , but it was such a mess to apply that I stopped.

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

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                    • L
                      LetTheRedeemed @Mauritio
                      last edited by

                      @Mauritio gotcha. Thanks for sharing

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                      • W
                        wester130 @LetTheRedeemed
                        last edited by

                        @LetTheRedeemed

                        a month ago someone mentioned topical ribose completely unconnected to this study though

                        https://old.reddit.com/r/raypeat/comments/1dlavfd/baldness_is_insulin_resistance_metformin_is/

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                        • L
                          LetTheRedeemed @wester130
                          last edited by

                          @wester130 nice, thanks for sharing

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                          • L
                            LetTheRedeemed
                            last edited by

                            @Amazoniac Yo brotha.

                            Do you have any thoughts on d-ribose supplementation? Could it have negative repercussions?

                            AmazoniacA 1 Reply Last reply Reply Quote 1
                            • AmazoniacA
                              Amazoniac @LetTheRedeemed
                              last edited by

                              @LetTheRedeemed

                              From what I can remember in posting about it on the Ray Peat Forum, supplementation is safe. In support:

                              • Sub-chronic (13-week) oral toxicity study with d-ribose in Wistar rats

                              I now have a support page!

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                              • L
                                LetTheRedeemed @Amazoniac
                                last edited by

                                @Amazoniac ah ok… thanks so much for the info

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                                • LejebocaL
                                  Lejeboca @LetTheRedeemed
                                  last edited by Lejeboca

                                  @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                                  EDIT: "it increases NO [nitric oxide is bad for metabolism] so according to danny roddy it is le bad." - sneedful
                                  Any references indicating this to be true or false would be appreciated.

                                  This review warns against high doses of D-ribose:
                                  https://www.spandidos-publications.com/10.3892/etm.2021.9927

                                  "In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means. D-ribose may glycosylate insulin to form ribosyl insulin, activate Caspase-9 and -3/-7, trigger transcription factor NF-κB and produce intracellular reactive oxygen species (ROS) that may cause cytotoxic damage to the surrounding tissues and cells, eventually leading to the manifestation of chronic complications (63)."

                                  So, I suppose, D-ribose may increase inducible NO (iNOS) by way of triggering NF-kappaB, which is a primary inflammatory response (see, e.g., pubmed here)

                                  Personally, i will avoid supplementing with D-ribose due to a possible NF-kappaB trigger, even not being a diabetic.

                                  Ben.B CiceroC 2 Replies Last reply Reply Quote 0
                                  • Ben.B
                                    Ben. @Lejeboca
                                    last edited by Ben.

                                    there is a thread about nad+ in the other forum and some researcher posted there that he uses b3 in combination with d-ribose in his patients ...

                                    i would assume he can say more about it.

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                                    • CiceroC
                                      Cicero @Lejeboca
                                      last edited by

                                      FYI, d-ribose and deoxyribose are not the same thing.

                                      https://commonchemistry.cas.org/detail?cas_rn=533-67-5
                                      https://commonchemistry.cas.org/detail?cas_rn=50-69-1

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                                      • CiceroC
                                        Cicero @LetTheRedeemed
                                        last edited by

                                        @LetTheRedeemed The nitric oxide thing might explain why it works--NO is said to be what makes minoxidil work.

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                                        • ?
                                          A Former User @OliverCloasov
                                          last edited by

                                          @OliverCloasov no im not saying he said this particular thing i am making fun of danny’s reductionist midwit bullshit

                                          i dont know or care about what danny has to say about this particular substance.

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                                          • L
                                            LetTheRedeemed @A Former User
                                            last edited by LetTheRedeemed

                                            @sneedful ah yes, the estrogen-cascade-blood-vessel-dilation theory of life. Danny's on the nose about the toxicity of NO.

                                            https://raypeat.com/articles/articles/dark-side-of-stress-learned-helplessness.shtml

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