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    Reversal of hair loss in Mice with “sugar gel”

    Literature Review
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    • O
      OliverCloasov @LetTheRedeemed
      last edited by

      @LetTheRedeemed I'm open to it

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      • O
        OliverCloasov @A Former User
        last edited by

        @sneedful Interesting, did he elaborate on the mechanism and the degree?

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        • Z
          zorba990 @LetTheRedeemed
          last edited by

          @LetTheRedeemed Wonder what would happen if I bubble hydrogen through ribose infused water?

          Found this on Amazon : https://www.amazon.com/RPI-2-Deoxy-D-Ribose-500-Grams/dp/B01N0X8O06

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          • L
            LetTheRedeemed @A Former User
            last edited by

            @sneedful dangit. in that case it could be working on hair growth thru the estrogen function: increase water retention, ie bloodflow

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            • L
              LetTheRedeemed
              last edited by

              Anybody recall Peat's quote on sugar helping hair growth? was he talking topical? I wonder what topical glucose + ATP + Progest E might do.

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              • B
                bot-mod
                last edited by

                This is so simple I could believe in it.

                Thanks for sharing it.

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                • H
                  Hearthfire @LetTheRedeemed
                  last edited by

                  @LetTheRedeemed

                  I found this thread talking about it, from a podcast/conversation with Ray Peat and Danny Roddy titled
                  "Lost Conversations with Ray Peat #1: The Purpose of Hair, Luciferianism, and Obama as a CIA Creation​

                  https://raypeatforum.com/community/threads/did-ray-peat-just-recommended-topical-honey-for-hair.50151/

                  Looks like that episode has been nuked off the internet by the censors. Probably for that title and the discussion content.

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                  • L
                    LetTheRedeemed @Hearthfire
                    last edited by

                    @Hearthfire brooo you came thru king.

                    I'm thinking a topical spray of glucose + a pro-energy substance like t3/niacinamide/aspirin!

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                    • L
                      LetTheRedeemed @bot-mod
                      last edited by

                      @ThinPicking right? Now I'm even more excited to try Ray's suggestion of topical glucose.

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                      • L
                        LetTheRedeemed
                        last edited by

                        @Mauritio
                        You said this in the old rpf thread above:

                        Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                        I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                        With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                        Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                        MauritioM 1 Reply Last reply Reply Quote 0
                        • MauritioM
                          Mauritio @LetTheRedeemed
                          last edited by

                          @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                          @Mauritio
                          You said this in the old rpf thread above:

                          Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
                          I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
                          With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

                          Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

                          It definitely helps . But I switched to using Apple juice because, it has sugar as well and because of the polyphenol content. Actually I dissolved a full capsule of swansons apple polyphenols in a bit of juice and applied it to my scalp . It really made a difference , but it was such a mess to apply that I stopped.

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

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                            LetTheRedeemed @Mauritio
                            last edited by

                            @Mauritio gotcha. Thanks for sharing

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                            • W
                              wester130 @LetTheRedeemed
                              last edited by

                              @LetTheRedeemed

                              a month ago someone mentioned topical ribose completely unconnected to this study though

                              https://old.reddit.com/r/raypeat/comments/1dlavfd/baldness_is_insulin_resistance_metformin_is/

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                              • L
                                LetTheRedeemed @wester130
                                last edited by

                                @wester130 nice, thanks for sharing

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                                • L
                                  LetTheRedeemed
                                  last edited by

                                  @Amazoniac Yo brotha.

                                  Do you have any thoughts on d-ribose supplementation? Could it have negative repercussions?

                                  AmazoniacA 1 Reply Last reply Reply Quote 1
                                  • AmazoniacA
                                    Amazoniac @LetTheRedeemed
                                    last edited by

                                    @LetTheRedeemed

                                    From what I can remember in posting about it on the Ray Peat Forum, supplementation is safe. In support:

                                    • Sub-chronic (13-week) oral toxicity study with d-ribose in Wistar rats

                                    I now have a support page!

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                                    • L
                                      LetTheRedeemed @Amazoniac
                                      last edited by

                                      @Amazoniac ah ok… thanks so much for the info

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                                      • LejebocaL
                                        Lejeboca @LetTheRedeemed
                                        last edited by Lejeboca

                                        @LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

                                        EDIT: "it increases NO [nitric oxide is bad for metabolism] so according to danny roddy it is le bad." - sneedful
                                        Any references indicating this to be true or false would be appreciated.

                                        This review warns against high doses of D-ribose:
                                        https://www.spandidos-publications.com/10.3892/etm.2021.9927

                                        "In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means. D-ribose may glycosylate insulin to form ribosyl insulin, activate Caspase-9 and -3/-7, trigger transcription factor NF-κB and produce intracellular reactive oxygen species (ROS) that may cause cytotoxic damage to the surrounding tissues and cells, eventually leading to the manifestation of chronic complications (63)."

                                        So, I suppose, D-ribose may increase inducible NO (iNOS) by way of triggering NF-kappaB, which is a primary inflammatory response (see, e.g., pubmed here)

                                        Personally, i will avoid supplementing with D-ribose due to a possible NF-kappaB trigger, even not being a diabetic.

                                        Ben.B CiceroC 2 Replies Last reply Reply Quote 0
                                        • Ben.B
                                          Ben. @Lejeboca
                                          last edited by Ben.

                                          there is a thread about nad+ in the other forum and some researcher posted there that he uses b3 in combination with d-ribose in his patients ...

                                          i would assume he can say more about it.

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                                          • CiceroC
                                            Cicero @Lejeboca
                                            last edited by

                                            FYI, d-ribose and deoxyribose are not the same thing.

                                            https://commonchemistry.cas.org/detail?cas_rn=533-67-5
                                            https://commonchemistry.cas.org/detail?cas_rn=50-69-1

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