Reversal of hair loss in Mice with “sugar gel”

[LetTheRedeemed]

@Mauritio
You said this in the old rpf thread above:

Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

[Mauritio]

@LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

@Mauritio
You said this in the old rpf thread above:

Interesting . Add a bit of T3 and caffeine to the mix and and you're good to go.
I already apply t3 dissolved in gin, so I might add plain table sugar and see if I notice an improvement.
With the t3 I notice an almost immediate improvement in hair quality and texture . Similar to the difference of a bad vs. a good hair day.

Did you notice anything? I'm wondering if you need to go pure glucose, not table sugar (50/50 fructose/glucose)

It definitely helps . But I switched to using Apple juice because, it has sugar as well and because of the polyphenol content. Actually I dissolved a full capsule of swansons apple polyphenols in a bit of juice and applied it to my scalp . It really made a difference , but it was such a mess to apply that I stopped.

[LetTheRedeemed]

@Mauritio gotcha. Thanks for sharing

[wester130]

@LetTheRedeemed

a month ago someone mentioned topical ribose completely unconnected to this study though

https://old.reddit.com/r/raypeat/comments/1dlavfd/baldness_is_insulin_resistance_metformin_is/

[LetTheRedeemed]

@wester130 nice, thanks for sharing

[LetTheRedeemed]

@Amazoniac Yo brotha.

Do you have any thoughts on d-ribose supplementation? Could it have negative repercussions?

[Amazoniac]

@LetTheRedeemed

From what I can remember in posting about it on the Ray Peat Forum, supplementation is safe. In support:

• Sub-chronic (13-week) oral toxicity study with d-ribose in Wistar rats

[LetTheRedeemed]

@Amazoniac ah ok… thanks so much for the info

[Lejeboca]

@LetTheRedeemed said in Reversal of hair loss in Mice with “sugar gel”:

EDIT: "it increases NO [nitric oxide is bad for metabolism] so according to danny roddy it is le bad." - sneedful
Any references indicating this to be true or false would be appreciated.

This review warns against high doses of D-ribose:
https://www.spandidos-publications.com/10.3892/etm.2021.9927

"In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means. D-ribose may glycosylate insulin to form ribosyl insulin, activate Caspase-9 and -3/-7, trigger transcription factor NF-κB and produce intracellular reactive oxygen species (ROS) that may cause cytotoxic damage to the surrounding tissues and cells, eventually leading to the manifestation of chronic complications (63)."

So, I suppose, D-ribose may increase inducible NO (iNOS) by way of triggering NF-kappaB, which is a primary inflammatory response (see, e.g., pubmed here)

Personally, i will avoid supplementing with D-ribose due to a possible NF-kappaB trigger, even not being a diabetic.

[Ben.]

there is a thread about nad+ in the other forum and some researcher posted there that he uses b3 in combination with d-ribose in his patients ...

i would assume he can say more about it.

[Cicero]

FYI, d-ribose and deoxyribose are not the same thing.

https://commonchemistry.cas.org/detail?cas_rn=533-67-5
https://commonchemistry.cas.org/detail?cas_rn=50-69-1

[Cicero]

@LetTheRedeemed The nitric oxide thing might explain why it works--NO is said to be what makes minoxidil work.

[A Former User]

@OliverCloasov no im not saying he said this particular thing i am making fun of danny’s reductionist midwit bullshit

i dont know or care about what danny has to say about this particular substance.

[LetTheRedeemed]

@sneedful ah yes, the estrogen-cascade-blood-vessel-dilation theory of life. Danny's on the nose about the toxicity of NO.

https://raypeat.com/articles/articles/dark-side-of-stress-learned-helplessness.shtml

[LetTheRedeemed]

@Cicero said in Reversal of hair loss in Mice with “sugar gel”:

FYI, d-ribose and deoxyribose are not the same thing.

https://commonchemistry.cas.org/detail?cas_rn=533-67-5
https://commonchemistry.cas.org/detail?cas_rn=50-69-1

Thanks, I know. They are different stages of the conversion of glucose toward atp.

Ray was a proponent of even putting sugar on the scalp, so my thought is that any step closer may provide additional benefits.

we can disregard sneedful's comments as he is noncontributory

[LetTheRedeemed]

@Ben thanks!

any chance you have a link? I'd be grateful if you shared! I don't have accounts in any other forum.

[OliverCloasov]

Wild idea here, but building on the topical sugar idea, any thoughts on mixing a target sugar with DMSO for topical use? I ask due to DMSO's penetrative boosting capability

[LetTheRedeemed]

@OliverCloasov I thought of that too, but I read that sugar dissolved in water is so easily absorbed by the skin that I just haven't messed with dmso yet. let us know if you try it.

I'm applying multiple times throughout the day across the whole scalp (to promote metabolism where blood flow is still good, thinking that must help), and about once or twice a day, I'm also applying t3, niacinamide, and haiduts oxidal, which contains methyline blue, niacinamide, and aspirin.

I apply a heaping amount of the d-ribose water immediately after applying the other substances, to avoid "starving" the scalp.

[Ben.]

@LetTheRedeemed

https://raypeatforum.com/community/threads/niacinamide-increases-atp-nad-lower-glucose-cortisol-in-humans.47075/post-826187

the user MC_55 seems to work with d-ribose and vitamin b3.

maybe its worth contacting him.

[LetTheRedeemed]

@Ben interesting. Thanks so much! Unfortunately I will never go back to the rpf, but I’ll still peruse threads of interest (usually the old er ones).

Let them know about this forum!