Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?

cs3000

O. basilicium water extract fully restored glucose & insulin measures in diabetes model
https://scialert.net/fulltext/?doi=pjbs.2020.1010.1017
increases glucose uptake by cells

& increased sleep duration on a sedative more than diazapam , decreased time taken to fall asleep a couple minutes by itself (through GABA) so maybe best timing is PM https://pmc.ncbi.nlm.nih.gov/articles/PMC5020426/#sec162951
extract with both water & ethanol solubles had greatest effect (potential for gaba rebound though)

Mauritio

Another reason to favor O. Basilicum !
Yeah it does have a glucose lowering effect. There's a few studies on basil as a diabetes treatment . I notice the hypoglycemic effect.

Interesting in that dosage it actually caused sleep issues for me . Although that was O. Sanctum and not O. Basilicum as in this study.

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/

Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

Mauritio

"The biochemical parameters of hepatic function, renal function, glucose, triglyceride, and cholesterol level were significantly reduced in the treatment groups compared with the control group (p < 0.05)"

https://pubmed.ncbi.nlm.nih.gov/39555564/#&gid=article-figures&pid=figure-1-uid-0

cs3000

@Mauritio
looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/
Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

Hearthfire

I've grown basil the last few years, it's amazing in stir fry. I got almost addicted to it, I wonder if my body was craving the effects it was having without me consciously noticing

I know what I'm definitely growing again this year
I'll probably do italian basil and holy basil to test out both.

Mauritio

@cs3000 said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

@Mauritio
looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
https://pubmed.ncbi.nlm.nih.gov/36750371/
Although in this study it showed no effect on sleep.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

Even the microdose (30mg) caused waking up to early for me. It felt like hypoglycemia, woke up with a pounding heart.

But maybe you're onto something with the GABA theory. GABA rebound is real.

I obtained dried powder of both basils and will continue experimenting.

Mauritio

@Hearthfire nice they used fresh basil in some studies so that's probably the best way to go!

wester130

could the alcohol tincture be used topically?

Mauritio

Yesterday I did 1g of basil (O. Basilicum)powder.

I took it in the morning and it had a strong relaxing /anti cortisol effect on me.
Muscles looked very full and less water retention as well.
During the afternoon I became a bit irritable and serotonergic ,but not sure if related at all. Might be due to gut issues from the day before.
I also felt quite confident and masculine. Totally recommend. Will try again .

And the best part was it didn't mess with my sleep like in my previous experiments with holy basil.
It was a bit harder to fall asleep but I didn't wake up early.
Maybe that was because it was basil and not holy basil this time, but maybe it was me taking it so early that the GABA rebound was over when i went to sleep.
I also took some limonene in the evening which increases GABA so maybe that flatened the GABA issues.

Today I woke up weighing 500g less and muscles looking Big and full . I had no morning wood today which is unusual . But some androgenic substances do that to me.

I still want to try 500mg and 25mg to see how that feels in comparison.

Hearthfire

@Mauritio Interesting. Keep us posted.

I gotta order a bunch of seeds soon. I'm gonna grow a ton of it to experiment with and put in stir fry.