Posts made by alfredoolivas

@jamezb46 Very very interesting, amazing comment.

@jamezb46 said in Dht, testosterone pre workout...:

Haidut’s explanation raises some questions: for one, even if caffeine increased cellular uptake of oxandrolone, if we suppose that without caffeine the same amount of oxandrolone was absorbed form the intestines, then wouldn’t a blood test for oxandrolone show the same amount of oxandrolone in the blood in both cases? Could the blood test discriminate between extracellular and intracellular oxandrolone?

Exactly... that is why the hypothesis of increased bioavailability makes sense but it doesn't at the same time

@jamezb46 said in Dht, testosterone pre workout...:

But if caffeine indeed increased cellular uptake, why wouldn’t the same be true with respect to endogenous androgens? Maybe it is true, but there are simply not that many endogenously produced androgens available in a physiological stage when people normally consume caffeine thus only leading to a marginal increase in total androgens inside cells when taking coffee as one normally would.

By what mechanism could caffeine increase cellular uptake of androgens? Well, here’s one thing I know: Lipophilic caffeine derivatives like pentoxifylline and their metabolites are known to be anti-viral agents.

Some anti-viral agents like adamantane are known to work by increasing the lipophilicity of cells, prohibiting the entrance of the virus into the cells.

Okay here we are getting somewhere I think. The lipophilicity of the cell only determines free steroids affinity for the cell. Not bound steroids. Inside the cell free steroids are the only steroids that can get metabolised by enzymes

If it a cell is more lipophilic - more free steroids will enter the cell - and since more free steroids are in the cell, more will get metabolised.

Therefore; the ratio of a steroid to it's metabolites shows the metabolism of a steroid, and since metabolism of a steroid is determined by the lipophilicty of the cell, the ratio of a steroid to it's metabolite is an indicator for the lipohilicty of the cell?

In the study mentioned, at oxandrolone's maximal concentrations, caffeine decreased the ratio of oxandrolone to it's metabolite epi oxandrolone by 25% (from 10 to 7.5), therefore caffeine increased the metabolsim of oxandrolone by 25%.

So either caffeine induces the enzymes that metabolise oxandrolone, or it increases the lipophilicity of the cell, and free steroids affinity for the cell, causing more free oxandrolone to enter the cell to be metabolised into epioxandrolone decreasing the ratio of oxandrolone to epioxandrolone.

@jamezb46 I love that study, very unknown for some reason.

What is interesting as you mentioned was that the oxandrolone crashed at the 8-hour mark, then rose and remained elevated for the rest of the 24 or so hours.

Their explanation for this was that caffeine increased the bioavailability of oxandrolone right? I find that hard to understand, Anavar has a bioavailability of 97% already.
"We postulate that caffeine increases the bioavailability of oxandrolone, probably by
increasing gut emptying. Practically this means that similar concentrations/effects may be
achieved using lower dosages. "

How can caffeine boost the bioavailability past 100%, to get 20x the concentration compared to the control group?

Haidut claimed it was due to increased cellular uptake of oxandrolone. What do you think?

@jamezb46 Thank you, do you think it would be worth taken in the evening-pre workout 3 times a week, for it's mental benefits?

@sushi_is_cringe @CO3 IdeaLabs has a really good success rate with delivering their products - their progesterone product is a white 15ml bottle, and it gets through customs and air port security every time; even when there is 6 different bottles in the package / carry on luggage.

@Ena Sugar is also white.... but when you dissolve it in water, the solution isn't white is it.... the same thing applies to progesterone.

@jamezb46 Any idea on Turinabol's safety profile? I know it is liver toxic, but how suppressive is it, is it nephrotoxic etc?
Also what mental effects do people report from it? It seems like a good steroid to run with T, from what I read, it gives a nice boost without any side effects.

@bio3nergetic thank you, I think it's okay to share the link. its in the name of science

@jamezb46 This too.

@jamezb46 Great comment.

@Mauritio I can't look stuff up on the RPF anymore due to a pay wall :(. Is there a long half life, therefore it should be only taken a few times a week? What were the "too much" symptoms from the 50mg doses?

@Mauritio You have me curious, have you tried this at all? Edit: You have, did you experience any mental benefits?

@sushi_is_cringe Halo does lower test, and it's crazy to say there is no risks of mental issues, but I actually investigated the liver side effects of Dianabol, and you may have a point.

@sushi_is_cringe Okay but Halostestin and DBol are extremely liver toxic right? You have to take proper time off, blood work and recovery to make sure your liver is okay. It seems silly to only care so much about LH and FSH and your gonads, and then ignore their toxic effects in other organs.

Furthermore, they all inhibit testosterone synthesis whilst you are on them, so testosterone derived neurosteroids such as 3a-Androstanediol and Androsterone will be depleted if you run orals by themselves.

And not to mention, the mental effects could potentially be very unpleasant and even affect your life negatively.

Amazing!

@jamezb46 I was talking about blocking cortisol at the receptor level. Yes, I expect many of them to increase cortisol due to 11 beta HSD 2 inhibition and AcTH being release, but overall, they are all anti-catabolic; fluoxymesterone actually binds to and antagonises the glucocorticoid receptor, amongst other anti-glucocorticoid mechanisms it may have.

https://pubmed.ncbi.nlm.nih.gov/173192/

"The synthetic androgen fluoxymesterone and the hormone testosterone displayed Ki values of 7.5 X 10(-6) M and 1 X 10(-5) M, respectively, for the inhibition of [3H]dexamethasone binding in muscle cytosol. On the basis of competition experiments it is postulated that interaction of androgens with glucocorticoid receptors prevents the binding of glucocorticoids and might be responsible in part for the anabolic effects of pharmacologic doses of androgens in muscle."

@sushi_is_cringe If you are interested in cycling D-Bol/methandienone, this study is helpful; it certainly seems possible to not have to do no PCT afterwards yes. However, in this study low doses of D-Bol were used.

https://www.tandfonline.com/doi/abs/10.3109/00365517709100649

"The effects of a one-month course of treatment with a p͟o͟t͟e͟n͟t͟ anabolic steroid, methandienone (5 and 10 mg daily), and a very weak androgen and hormone precursor, dehydroepiandrosterone sulphate (DHEAS, 20 and 40 mg daily) and placebo on plasma testosterone, LH and FSH levels, red cell volume and red cell 2,3-diphosphoglycerate (2,3-DPG) concentration in endurance sportsmen were studied using a double-blind test system. A highly significant decrease in mean plasma testosterone was observed after the 5 and 10 mg methandienone regimen (66 and 73%). Treatment with 40 mg of DHEAS decreased mean testosterone levels by 41% (not statistically significant). P͟r͟e͟-͟t͟e͟s͟t͟ ͟t͟e͟s͟t͟o͟s͟t͟e͟r͟o͟n͟e͟ ͟l͟e͟v͟e͟l͟s͟ ͟w͟e͟r͟e͟ ͟r͟e͟a͟t͟t͟a͟i͟n͟e͟d͟ ͟a͟b͟o͟u͟t͟ ͟1͟0͟ ͟d͟a͟y͟s͟ ͟a͟f͟t͟e͟r͟ ͟t͟h͟e͟ ͟e͟n͟d͟ ͟o͟f͟ ͟t͟h͟e͟ ͟t͟r͟e͟a͟t͟m͟e͟n͟t͟ ͟p͟e͟r͟i͟o͟d͟ ͟w͟i͟t͟h͟ ͟t͟h͟e͟ ͟h͟i͟g͟h͟e͟r͟ ͟d͟o͟s͟e͟s͟ ͟o͟f͟ ͟b͟o͟t͟h͟ ͟c͟o͟m͟p͟o͟u͟n͟d͟s͟, while 2–6 weeks afterwards a significant over-compensation in mean plasma testosterone levels was observed."

@CO3 So is it or is it not rancid?

@sushi_is_cringe Testosterone falling is worse than LH and FSH falling. It is a sign that the gonads aren't working properly, whereas LH and FSH falling are simply a sign that the pituitary detects there is too many androgens.

Anavar blocks cortisol receptor transcription, via activating the androgen receptor. Androgens in general are antagonistic to cortisol, via activating the androgen receptor. D-Bol is likely anti-catabolic too, despite increasing cortisol levels. Only trenbolone, and M-Tren, directly binds to and blocks the glucocorticoid receptor as far as I know.

https://pubmed.ncbi.nlm.nih.gov/15219414/

@jamezb46 Haidut says a lot of stuff man... here is a clip of him saying a few mgs of exemestane, allows him to drink 2 litres of Vodka in a single night. In most countries that is equivalent to 67 shots of vodka...
https://youtu.be/KSuhf6PS2jk?si=-rTm2tGK4uZeap4b&t=4670

I wouldn't take his words as gospel.

@jamezb46 That is not true, I am pretty sure that idea was conjecture, spread by Haidut back in the day. I have had 600mg of caffeine and 10-15mg caffeine on the same day, and no, it felt like 600mg of caffeine not 6000mg.