Posts made by alfredoolivas

@gloryus

On the original Reddit post, this user said it worked.
It absorbs well and dries fast in my experience.

@sushi_is_cringe Yes lol. It was a clinical trial. I was amazed too

@sushi_is_cringe Oral administration of steroids massively reduces the half-life of steroids + their bioavailability + increases the metabolism of the steroid, so you will get less unmetabolized steroid per dose (which can be a good and bad thing - bad in this case).

Testosterone undecanoate when injected has a half-life of a month - when orally injested? The half-life is a few hours.

The bioavailability of these oral steroids is significantly reduced as well - and even when the bioavailability of oral testosterone undecanoate in combination with a fatty meal is made 120%, the half life is still a few hours!

The low bioavailability and rapid metabolism of oral hormones explain why a weekly dose of 3500 mg of testosterone undecanoate dissolved in vitamin E could be administered to patients for the treatment of Nonalcoholic Steatohepatitis without causing side effects or muscle growth. In contrast, administering this amount via injections would lead to accumulation, eventually resulting in 22 grams of testosterone undecanoate in the body at some point.
https://clinicaltrials.gov/study/NCT04134091

Due to testosterone's protective effect on the liver, a clinical study was done using daily administrations of 500mg (3500mg a week) of oral testosterone undecanoate dissolved in your favourite solvent - vitamin E. Testosterone undecanoate has a half life of a month when injected - if testsosterone undecanoate's half life orally was the same as it's intramuscular half life, the testosterone undecanoate would build up to the point where there would be 22 grams of testosterone undecanoate in your blood stream.

If you had 22 grams of testosterone undecanoate in your bloodstream you would suffer extreme side effects, and look like the hulk?
Well none of that happened, because testosterone undeconate and oral steroids in general, have awful bioavailability and half life as discussed before:
Daily administration of 500mg of oral testosterone undecanoate dissolved in vitamin E was able to grow muscle mass by..... 1.9% to 2.75%

And only 10% of these patients adminstered these crazy doses of test undecanoate had side effects

There was also a fall in triglycerides and total cholesterol on average.

TLDR: As shown by a pharmacokinetics study, oral administration of testosterone and testosterone undecanoate, can bring their half lifes to a matter of hours, and give them low bioavailability. This is why patients with Nonalcoholic Steatohepatitis can take 500mg of testosterone undecanoate a day (dissolved in vitamin E) and gain no muscle and have no side effects - the latter is extremely surprising given how in bad health they are.

@jamezb46

Subcutaneous DHT administration can provide a sustained release of unmetabolized DHT into the bloodstream over several days, offering similar benefits to esterified DHT

However, the big issue with delivering unesterified steroid subcutaneously or intramuscularly, is that they are very insoluble - typically a mix of benzyl benzoate or propylene glycol with water or oil is what the unesterified steroids are dissolved in.

The issue is that 1.) they tend to be dissolved at extremely low concentrations - 50mg per ml (I think) - 2.) they use high amounts of benzyl benzoate and propylene glycol (up to 50% v/v I think) which are toxic. This means that to administer a considerable amount of unesterifed steroid, you will need to administer a lot of toxic solvents with it. However, this isn't even the biggest issue - these unesterified steroid solutions are INFAMOUS for crashing / the unesterfied steroids precipitate out of the solution. When you inject this precipitated solution, it cannot get absorbed into the blood stream, and as a result, a cyst and swelling occurs in the injection site - it is extremely painful and if this happens during an IM injection, it causes your muscles to not work properly- if you do an injection in your quad and this happens? You can lose the ability to walk for a few days (talking from personal expereince).

However; there may be a solution - tocopherol is an excelent solvent for unesterfied steroids - I have made stable 30% progesterone solutions in tocopherol, whereas a 5% progesterone solution in benzyl benzoate wasn't stable. Therefore, the use of tocopherol in place of benzl benzoate or propylene glycol, could fix all of the issues I described above. That being said, tocopherol is very viscous - I am afraid that injecting tocopherol inside oneself, could create a depot of oil that will take too long to get absorbed - potentially forming a cyst around the injection depot. A possible solution to this, would be combining a very small amount of tocopherol with a large amount of oil that has a very low viscocity such as MCT oil - it would make a solution with a safe viscocity, that can still dissolve steroids - for example; one could have a 10% mixed tocopherol and 90% MCT oil solution - you could make maybe 2% of the solution DHT (20mg per 1ml)

If you get the viscocity issue correct, subcutaneous DHT dissolved in tocopherols and MCT, should safely deliver constant umetabolised DHT into your bloodstream for a few days. This is a cheap experiment I may plan to do over the summer.

@jamezb46 Yes, and someone who has a lab or synthesises drugs at home will probably be synthesising esterified DHT as a business - and unless he wants to synthesise DHT on his own, he will have to import bricks of DHT every month through customs... which is impossible given it's current supply and how easy it is to get caught.

The only way DHT enanthate is becoming available to the public is if someone on this "esterified DHT hype train" is rich enough to get a Chinese company to manufacture it for him, clever enough to ensure it is a pure product and to know how to homebrew it into oil vials, and stupid enough to sell steroids (very illegal) or if the UGL labs (the main clients to the chinese steroid labs) want to start selling it - but the UGL labs aren't rich enough either - they simply heat up oils and benzyl benzoate in a beaker and throw steroids into it, and then sell it amongst 100s of other labs that sell the exact same product at the same prices. They don't exactly try to make advancements in the steroid industry or change the game.

@Corngold Sure he may of talked about the importance of endogenous progesterone in men but did he specifically recommended men to take substantial exogenous doses of it? Rarely in my opinion.

@wester130 said in Peat did not believe in the androgenic man?:

His love of painting, art and poetry

Peat was old. He did old people stuff. When he was young (as well as later in life) he also was possibly more of a nerd/intelectuall/ scholar/bookworm(I mean none of those words with disrespect). It's likely the time he was born and upbringing, that lead to these preferences, not hormones.

His recommendation of progesterone

He seldomly recommended it to men, and when he did, it was recomended in low doses, often paired with DHEA. He has talked many times about the anti androgenic effects of progesterone.

A preference for an introspective, reflective thoughtful life

This is androgenic.

@jamezb46 HPLC testing can be done for less than $100 a test. You could identify the purity of the DHT ester, presence of heavy metals and maybe even the presence of other reactants used in the synthesis for as little as $300 I would say. Would that not suffice?

https://janoshik.com/pricing/
Janoshik performs identification assays of common AAS and heavy metals for as little as $60. I am sure other traces of other reagants could be organised as well.

@jamezb46 It's a common trend that drugs (all types) become more effective but also more toxic when a fluorine atom is added to the molecule. Not sure why.

@AL They are fake. He marks the QR code and Serial numbers with a pen, so you can't scan them on a certain turkish medicine verification app (the name is in a foreign language), and verify if the medication is real or counterfeit.

I have probbaly bought close to 30 packs of Tiromel and Bitiron combined from him, before he started to mark out the QR codes - when I scanned their QR codes ALL of them were not registered batches and were therefore fake.

Save yourself hundreds of dollars and stay away from Turkish meds - generally, if you see a very popular medicine being sold for low prices, it is too good to be true.
A small sample of my fake thyroid collection....

@drain-gang https://www.farmaciasdirect.eu/products/periactin-4-mg-30-tablets

@sushi_is_cringe high risk high reward.

@Korven It’s likely that you just want the dopamine.

If a “normie” ex-smoker was in your situation, and wanted to have a cigarette, would you think his body desires the nutrients, NAD boost etc of smoking or does he just desire the pleasure of smoking a cigarette?

The latter makes much more sense, smoke a cigarette if you choose to do so, but let’s not cover it up with some fancy biochemical reasoning.

Smoking is pleasurable and that’s a large reason it’s desirable, and why people quitting cigarettes return to cigarettes, even though they are getting way more nicotine at steadier concentrations, through gum and patches

@samson Fascinating thank you

@dht Haidut was ahead of the time, he made these posts nearly 10 years ago, long before anyone was talking about it.

@sushi_is_cringe @dht DHT was the first real androgen I started with, I used 25mg (dissolved in DMSO) topically a day, and I did like the effects.

The issue is that it is hard to get DHT nowadays, China has had a major crackdown on steroids, and all steroids are more scarce. DHT has basically disappeared and but PPL customer service said they plan to restock it.

@sushi_is_cringe sometimes 2 lbs it depends on the day

@sushi_is_cringe 4g a day (chicken breast) currently. I have avoided it for nearly 4 years, but I still ate eggs and salmon a bit for the first year. I went to a close to zero PUFA 2 and a half years ago when I removed eggs and salmon from my diet, and I did a zero fat diet for a year, until last September.

@dht yeah I have studies showing androgen receptor agonism decreases aromatase, blocks estrogen receptor translocation, and androgens such as testosterone, DHT and nandrolone, being able to block estradiol from binding to the receptor directly.

I also have a rodent study that showed pregnenolone yes, but also testosterone being able to block testicular atrophy from steroid use.

I think androgens by themselves can lower LH and FSH, and lowering estradiol with an AI or lowering prolactin isn’t enough to recover the supressed pituarity, otherwise DHT and its derivatives would be non supressive - unless they are estrogrnjc too by some unknown mechanism (metabolites such as 3a androstenediol)

Peat said testosterone was anti estrogneic once and I think he was on to something, that was discovered and discussed back in the 20th century

@dht well based on experience, observations and older studies to be honest, I have a “holistic ” theory that it is acting identical to progesterone in my body. Can’t prove it or justify it to anyone but myself.

@dht lots of crossover with androgens and thyroid. Both are beneficial to mitochondria, even the toxic androgens like winstrol.

Both are anti-cortisol and estrogenic too