Dandruff or scalp irritation? Try BLOO.
@Santosh said in Experiments with transdermal hormones:
What specific points make you think I do ?
Elaborate, don't just throw sarcastic questions especially while hypocritically prefacing they are genuine.
Why would I elaborate when you won't read it anyways? That's the point.
I'm not hypocritical, though. If you answer genuinely, I will too. Not everyone's like you
@Mauritio said in Cyanidin-3-O-glucoside (C3G), the next polyphenolic StAR ?:
Thanks for mentioning. I forgot about taking it. It made me kind of wired but tired after a while ,but I did enjoy it. And might try it again.
Oops. I actually wrote this like a month ago, but when accessing the forum yesterday from my phone this posted for whatever reason and I didn't notice.
I've also stopped using it. It was just way too damn stimulating on the digestive system. I did like the pro-dopamine effects though, very noticeable and powerful, most definitely.
Thanks for putting all of this together, @Mauritio .
I kept an eye on the thread at RPF and was mildly interested, but when I saw that it induces uncoupling AND it increases bile output, I just had to try it.
Like someone mentioned on the other thread, using this with Pu-erh is probably going to be highly effective. The increased use of acetylcoa into cholesterol and increased bile acid synthesis is going to be super effective for reducing reductive stress, not to mention the uncoupling effect and enhanced sirt6 activity.
Then you have the increased star activity too. Thus is just a really cool compound.
So far I’m on day two, and I can say that it does really work for stimulating digestion. I have an issue with sluggish peristalsis that weakly responds to pretty much everything. Huperzine A seems moderately effective, but higher than 200mcg I get cramps. Magnesium sucks, and everything else is kind of useless.
I’ve taken two doses so far, and both times it crashed me pretty hard, mainly because my digestive system started working too abruptly. I’m thunking that if I keep going,
@Kilgore said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@brightside said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@Kilgore Yeah, they tried to pass it off as a different substance.
Test Base is #37, and Test prop is #1. I got a bag of #37...
Not sure if this reply is to me but I dont really understand exactly what you mean here.
Either that, or they are using esterified DHT which has a much better solubility.
I will ask them about this actually.
Oh, oops, that wasn’t to you.
But I’m saying that they label their products with a number instead of an actual label with words.
@Santosh said in Experiments with transdermal hormones:
@brightside said in Experiments with transdermal hormones:
@Santosh said in Experiments with transdermal hormones:
Oh I see, this whole thing is about your ego.
You can't accept that I started making threads about my discoveries back in 2019, and you arrived LONG after.Imagine my ego being tied to the topic of transdermal hormones LOL
I care about accurate information, which you bring none.
Notice how in my RPF thread, anytime I bring up any argument you keep deflecting and changing the topic or going for an attack. You never actually say anything.
Case in point being your reply to me just now.
Why switch your opinion?
Where's the logic and reasoning?
Where's the proof for such a bold claim?
Where's literally anything of substance?Man, I don't really care. You can stroke your ego all you want, just don't do it in my thread. This thread is for accurate information and brainstorming.
"Your" thread doesn't exist if I don't bring up the topic of transdermal hormones in September 2019 both on the RPF and on MesoRx with my homemade formulas, both the DMSO one and the Ethanol/MCT one.
You piggy backed on my threads making small adjustments to the formula that bring nothing new to the absorption rate.
Switch my opinion to what ? I always had the same.
Would you like a cookie?
Actually, if anyone deserves to be called a pioneer, it’s this guy from 2002.
Genuine question, do you have a problem with reading comprehension?
@Kilgore Yeah, they tried to pass it off as a different substance.
Test Base is #37, and Test prop is #1. I got a bag of #37...
@Kilgore said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@brightside said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
Anyone who's used DHT base before knows that it dissolves up to 50mg/ml max.
@Mulloch94 said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
alphagels has top notch DHT
Interesting cause Alphagels claims:
"We have transdermal DHT gel available in two strengths:
10% DHT (100mg/ml)
20% DHT (200mg/ml)"Or are there different ways DHT can be dissolved?
Also will taking DHT stop natural testosterone production? Can you point me to the best info I can read up on this?
Yeah, that's BS.
Either that, or they are using esterified DHT which has a much better solubility.
@Mulloch94 How would you compare DashPCT vs places like farmacias del nino and alldaychemist?
@milkgains_bro said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@brightside I had very good experience with Qingdao Sigma Chemical Co. You can check their thread on ThinkSteroids with latest review etc. They had good amount of raws in ther portfolio.
Sweet, thanks for the comment. I'll def use them when I buy more raws
@Santosh said in Experiments with transdermal hormones:
Oh I see, this whole thing is about your ego.
You can't accept that I started making threads about my discoveries back in 2019, and you arrived LONG after.
Imagine my ego being tied to the topic of transdermal hormones LOL
I care about accurate information, which you bring none.
Notice how in my RPF thread, anytime I bring up any argument you keep deflecting and changing the topic or going for an attack. You never actually say anything.
Case in point being your reply to me just now.
Why switch your opinion?
Where's the logic and reasoning?
Where's the proof for such a bold claim?
Where's literally anything of substance?
Man, I don't really care. You can stroke your ego all you want, just don't do it in my thread. This thread is for accurate information and brainstorming.
I wish I had a better answer, but honestly - IDK.
I've been using a combination of scrotal T cream and DMSO + Test. However, since the test I have is apparently Test Prop, I can't really compare that to the T base, and can't say what would be the most effective or beneficial.
I can definitely feel that this test has a much slower come-up, and doesn't provide as much of a kick as T base would. Using scrotally, I feel a mild kick, and then it fades away after half a day, so I need to reapply, typically 2-3x per day. (I use 1pump @ 18.75mg / pump )
The DMSO that I use on my thigh at night seems to last all day?? but I don't really feel anything dramatic, which is probably good. I'd have to get bloods to tell you if it was actually getting me to good levels, but I feel perfectly fine. It also absorbs quite poorly, and feels fatty for a while before it crystalizes.
I've just recently gotten some kefir grains and started making and drinking kefir. It seems to be helping my gut quite a bit. If that works out, then I would be able to get a much better idea of which test application method works best, since gut issues really mask a lot of the effects of androgens.
@Mulloch94 said in Experiments with transdermal hormones:
@brightside Interesting. So MCT oil would be a viable co-solvent along with ethanol? I only ask because I've never used it. Tocopherol has been an excellent lipid-based compound and I haven't had the need to venture out much further than that. It also mixes with more volatile solvents like ethanol without an issue too. I've noticed a mixture of ethanol & tocopherol to be particularly useful in getting DHT it solvent quite easily, which I've always noticed can be tricky as it's slightly more temperamental than normal T base.
I personally don't see a reason to use it.
In order to boost penetration of fat soluble actives, you need to disrupt the lipid matrix. (unless relying on other mechanisms like denaturation of keratin proteins like DMSO) Fats like MCT and olive oil do do this, but only because they are a lipid that's not as structured as your lipid matrix. Pretty much any fat is less structured than your lipid matrix.
But, if you look at the stratum corneum lipid matrix, you can see that triglycerides are kind of massive in relation to everything else.
Why would you use more stable molecules, like MCT or other triglycerides instead of opting for smaller, more volatile and more disruptive lipids? (surfactants too) Simply switching from triglycerides to fatty acids drives up absorption dramatically, especially if the fatty acid is short or unsaturated.
Actually, I have yet to see a single study that says MCT oil is effective at increasing transdermal penetration of hormones.
Not only that, but MCT does not hold any hormone. MCT also sucks at mixing with ethanol. I did an experiment a year ago with a three dishes containing ethanol, ethanol+MCT, and ethanol+stearyl alcohol. The ethanol+MCT one crashed a few hours in (I was testing evaporation speed, so they were uncovered). I started out with roughly 80% Ethanol, 20% MCT, so that means the point at which it crashed was probably like 30% MCT, and 70% Ethanol? Something like that, but I never experimented to confirm.
To summarize, MCT isn't that miscible with ethanol, it's not a penetration enhancer, and it doesn't even hold any hormone. So then, why use it?
Moisturization is the only use I see.
Sorry for my little rant lol
It's interesting about the vitamin E. I wrongfully discounted it in the beginning, but clearly you and others are having good experiences with it. I'm kind of put off of the idea of using tocopherols since they are so thick. What kind of tocopherols are you using?
I'm asking because I'm concerned about the policosanols that are in the TocoVit type stuff. Since they're very long acids, they would probably add a structuring effect to the lipid matrix - something I don't want. Also, I'm curious if Vitamin E's effect comes from not necessarily by disruption, but by enhancing solubility of the hormone, like you mention.
Hmm, what do you think about this?
@Mulloch94 said in Experiments with transdermal hormones:
@Santosh Thanks, yeah I didn't know IPM was that useful as a co-solvent. Apparently it's stronger than ethanol, and when mixed in a 2:1 ratio with ethanol enhances the capability, at least with Cialis.
@Santosh said in Experiments with transdermal hormones:
Not only is salvo expensive, it's also a terrible health choice.
I already knew about benzyl alcohol's toxicity issue, but I wanted to see how I'd react nonetheless. Yeah not good. My skin was sensitive to it for one thing, but I also generally did not feel good when using their anti-estrogen product Virtus. Not sure if it lowered my estrogen too much or was related to the other ingredients, or both.
It's really not. The numbers for T's absorption come mostly from studies using AndroGel, something that has ethanol + IPM + carbomer. Those numbers are 9-14% absorbed hormone. IPM boosts the flux quite substantially, up to 11x in some study, but that just means you absorb the hormone faster, not necessarily more. ( you do end up absorbing more, especially since the IPM helps the Test stay dissolved on the skin, but, again, thats boosting it up to only a measly 9-14%.. )
I'm not saying IPM is a bad penetration enhancer, but just stating the facts, since Santosh likes to make up BS to make himself seem like the pioneer he really craves to be.
Also, this is just me being picky, but IPM is not a co-solvent (in the case of T), but a penetration enhancer. You can't dissolve a meaningful amount of hormone in IPM, and it doesn't increase the solvent capacity of mixtures either. (But to be fair, it seems to with Cialis, as mentioned in the study above).
@Santosh said in Experiments with transdermal hormones:
I'm going to put an end to the dozens of messages I receive in my inbox on this forum : yes, ethanol + MCT oil + IPM has the best convenience and absorption profile of all transdermal methods, no DMSO is not ideal.
I use DMSO solutions when I want to elicit deep transcriptional changes, such as anchoring a long lasting androgenic state by megadosing DHT in DMSO for a few days.
???
Now it's the "best convenience and absorption profile of all transdermal methods"?
Why do you always talk with such pride? If you really wanted to put an end to the questions (or just be helpful) you would make a post about it, put it on your profile, or something of that sort.
I emailed them a year ago. I don't think this information is proprietary, since they shared it freely, but if anything I'll remove the image.
The actually effective fatty acids in their mixture are are the shorter chain ones (namely C8, C10, and C12). Those fats are incredibly smelly, and you would know about them in your product instantly. This means that they are in such low quantities that it's basically meaningless (or that their ratio is heavily skewed towards C14, and C16).
For example, when I used lauric acid, even in low <5% amounts, I can smell it on my skin for hours. Out of the medium chain fatty acids, LA is by far the best smelling (smells kind of chemically, not horrible but not good either), so if there would be any meaningful amount of C8 or C10, you would smell like you were rolling around with goats and sweat.
Basically, the SFA esters don't add much to the product, and in my opinion they might as well just use MCT oil.
@Santosh said in Any experiences with DHT?:
Mast was very disappointing, even when used in high doses as a transdermal in a Benzyl alcohol solution.
So far only testosterone gives me good emotional and sexual feelings.I might give Tren base a try.
What exactly are you searching for?
@Mulloch94 said in Any experiences with DHT?:
Have tried normal DHT as well? I've been curious to here people's testimonies on how masteron compares to normal dht. I have a small baggie of Mast P but never used it.
Yessir. I've been using it probably for almost a solid 9 months at this point at a dose of 10-25mg a day.
The Mast didn't seem worth it, and I probably won't use it unless I run out of DHT. For my situation, the DHT is exactly what I need.
Dammit, I had a response typed out and I accidentally closed the tab and it didn't keep it for whatever reason.
I'm not sure what you're arguing for, though.
Topical androgens are generally less estrogenic than injected ones, and that's mainly due to the DHT. Sure it's not super potent, but it's still superior, IMO.
Even if you suppress yourself a bit, you will still exert a more potent androgen pressure on your tissues than without the DHT. So at the end of the day, it's still a win. The stories of people liking T + DHT instead of T + AI, is partial proof of that (although it's not fair, since they're on complete replacement)
The doses I've been using almost total to the 150mg you mention, as well. I do notice suppression at that dose, but like I said, I still come out on top.
I'll put it this way, I'd rather be partially suppressed from a high DHT level, versus a high estrogen level.
@Santosh said in Any experiences with DHT?:
@brightside said in Any experiences with DHT?:
Best hormone. DHT > all others.
Clarity, energy, estrogen reduction, decreased inflammation and autoimmune like no other hormone.
It's not magic, but it's damn good.
It's even more helpful when you're actually sick, while T is much more hit-or-miss
How do you like it compared to Proviron ?
Haven't tried. I have tried Mast, though, and that was definitely interesting and different. Obnoxiously strong morning wood and erections, and I did see what people meant by mood benefits from Mast.
@tea said in PSA TO ALL PPL/DO (PurplePandaLabs/DragonOrdnance) SHOPPERS:
@thyroidchor27 Idealabs not updating the product photos irks me so bad. Let's see what happens with the product info being linked to what used to be rpf.
For real. I wanted to email them so they would send me empty bottles to take pictures with so that I would have nicer pictures to look at lmao