"I believe Ray said something like until you get the gut fixed, going after liver/thyroid won’t work well because you will have a continued source of estrogen and serotonin elevation via gut health, impacting liver/thyroid"
Ray said lots of things about gut health and very little of it makes sense. Estrogen only has a modulatory role in gut transit and gut function in general. There's no way for it to greatly influence or impact homeostasis in the gut. Again with the serotonin shit..you do know that the very thing that allows the intestines to contract and perform a bowel movement rely almost exclusively on serotonin, right? Both the ENS and MMC rely exclusively on multiple 5-HT receptors given that the gut houses of 95% serotonin receptors and produces 90% of serotonin. it's in everything from the enterocytes to the microvilli. The gut does not and cannot function optimally without it. Cascara anthroquinones, the darling of Peats bowel stimulants retards MMC by down regulating serotonin receptors in the gut and can also damages enteric neurons due to how powerfully it causes contractions in intestines. Those painful cow patties it produces after using it for a while and senna for that matter are because the MMC and ENS are not doing what they are supposed to be doing, and they need serotonin receptors to do it. There's not some magical alternate pathway you can tap into through focussing solely on cellular respiration. That's just how it is