Topics created by pittybitty

@pittybitty said in What helps improve executive function?:

I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains.

Give details, please, because it's not with a B-50 multi you're going to have a game changer.
You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis.
And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people.

Potential roles of Vit B6 in inflammation and immunity.

Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633
Main ideas
• Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1)
• Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine).
• Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6)
• Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11)
• The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications.
• Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP.
• Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16)
• It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18)
Sources and References (in English, on the link, my forum).

See too:
English Corner – Vit B6: How much is too much?
Main ideas

Too much of a good thing is bad.

Especially bad for neuro-sensitive people.

Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP.

And for B1 thiamin
*) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal
Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019
*) ## Thiamine and the Microbiome – Dr. Lonsdale
https://www.hormonesmatter.com/thiamine-microbiome/ 03/23
Excerpt:
The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .

@Peatslop-enjoyer said in What Vitamin B cofactors should I supplement?:

Could you provide the link? Thank you.

Vitamin B6: How much is too much? Which kind, with staples.
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
Excerpt:
The English Corner – Vit B6: How much is too much?
Main ideas

Too much of a good thing is bad. Especially bad for neuro-sensitive people. Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP. Look at the 6 vitamers form before continuing (figure):
3 basic forms of vitamers B6: PN= pyridoxine PL = pyridoxal PM = pyridoxamine

And their derivative, coupled with a phosphate molecule:

PNP = pyridoxine 5’-phosphate PLP = Pyridoxal 5’-Phosphate (active form) PMP = Pyridoxamine 5’-Phosphate

And the form used as a catabolite (excreted in the urine)

PA = 4-Pyridoxic acid.

A tight regulation of the PLP concentration is necessary in the cell: The aldehydes are toxic. A self -regulation and a protective mechanism coexist. But there is a radical side effect: PLP will no longer passes the encephalic barrier. A withdrawal effect will soon take place, with an impact on neurotransmitters.

PMP is a safer form: PMP is slightly increased in plasma, and rapidly converted into PLP and PL when needed.

An excess of pyridoxine (PN) is deleterious. No pyridoxine supplement advised: PN has an inhibition effect on PLP, the active form.

PL could be converted to PN by a PL reductase (side effects when too high supplementation).

PM could be more suitable for supplementation because of the very low formation of PN by PM.

If we suffer from a lack of enzymes, we must pay attention to the conversion pathway: PLP as a coenzyme factor has a pivotal role in catalysis of various enzymatic reactions.

See the roles of PNP-dependent enzymes, namely kinase and oxidase (+ phosphatase).
To be continued on the link. See above (my forum: Mirzoune et Ciboulette).

A tight regulation of the PLP concentration is necessary in the cell: The aldehydes are toxic.
We must not go beyond the absorption capacity of the body. We are not all equal. If you suffer from inflammation, if you need more antioxidants, you will probably burn more B6. What should be avoided is to approach the limit / the level of an overburdened of metabolism. A limit that will be different, depending on the individual.
Why does an excess of B6 or an inadequate enzymatic metabolism cause a problem of neuro-sensitivity? An excess of Pyridoxal (PLP) will lead to the inhibition of the enzyme PLK (Pyridoxal Kinase). PLK is set out of function via the “Salvage pathway” process. Details on the link, with references.
Useful link
*) English corner: B6 leads to decrease of cytokines in neuropathy
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
Efficacy of Vitamin B1, B6, and B12 in Peripheral Neuropathy
*) Useful nutrients in case of neuropathy
https://mirzoune-ciboulette.forumactif.org/t2031-haute-dose-de-b6-p5p-contre-algodystrophie-et-scc#29618
Mg bisglycinate, Zinc, Vit B6 PLP 20-25 mg, Vit C 500 mg, Vit D 5 000 UI (with K2).
*) English Corner: Anti-Stress & Neuro-Protective Effects of Thiamine (B1)
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1

See part 2 (in the same post): How much and which kind of thiamine?
Excerpt from video of Dr. Allil OVERTON.
=> Practical example for beginner (patient N° 1): Basic protocol for thiamin insufficiency.
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29716
With references.

Maybe look into gut bacteria and soil bacteria and how they are similar. I'm currently making a post about this but I'm still doing the reading. The bacteria in the gut can make B vits

@questforhealth I think the high concentration of B vitamins and magnesium far outweighs the cost of the high MUFA ratio, especially if you eat lean cuts.

I just ate a single pork chop and I already feel so much better, it's a life saver right now.

@pittybitty I would take antibiotics. Either azithromycin or doxycycline or penicillan. Charcoal and well-cooked mushrooms.

I like pork! obvious downsides to it in the sense that'll eat anything and it does not have multiple ruminant stomachs. So I wouldn't eat US pork at all, since you guys feed them plastic and shit.

I have some chorizo, fried in coconut oil, but eating cured (old) meats is apparently much worse than fresh. So the best form of pork would be like a cutlet fried in tallow, butter or coconut oil. I agree it makes a lot more sense metabolically than beef, especially from older animals. Lamb I think is better than both most of the time.

i think they are serotonergic. cooking them seems to reduce this. Fresh salsas upset my digestion, cooked or can salsas do not.

@santiagotrad That's a good option! Pricey, but if it works it works

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

Those raccoons also feast on koi in Singapore. I don't have that problem here in our overcrowded Manila. I have a mind to move to the mountains, but when push comes to shove, I procrastinate because the idea on becoming a nomad appeals to me as well.

Decisions, decisions.... I moved here from a big metropolis in 1981. I went through a bad divorce (is there any other kind?) and decided to get out of Dodge when the divorce was finalized by the Court. It was the best decision I ever made (next to that divorce). It was an amazing little town in the early 1980's. Nobody locked their doors; they kept their keys and money in their vehicles (unlocked). If a stranger needed a ride to somewhere, people were known to just hand them the keys and say, "Here, take my truck." People were so scarce in the county back then that everyone always waved when passing another vehicle on the road, acknowledging the other human being. The times have changed the place; too many tourists now. I miss my little town.

@API-Beast I’m unsure. I know for myself, cooking rice pilaf well in bone broth was great for quick, digestible starches with no blood sugar “crash” feel. Same with jasmine rice and sweet potatoes.