Posts made by the MOUSE

@CO2Master thoughts on butekyo and acidosis?

https://kahn642.medium.com/metabolic-endotoxemia-the-link-between-the-chronic-diseases-and-the-saturated-fats-you-want-to-eda04c8623e4

A cardiologist does not normally lecture on bacteria, stool, or the intestinal barrier. But I traveled to Philadelphia to lecture to a medical audience on the growing overlap of GI health and cardiovascular health. One example is the metabolite TMAO which is produced in part in the intestinal wall and liver and impacts cardiovascular health.
Another example of the Gut-Heart nexus that is perhaps of even greater importance is the topic of metabolic endotoxemia or ME for short. A brief dive into this body of science will identify that ME may be the most important pathway leading to chronic diseases such as atherosclerosis, diabetes, obesity, dementia and cancer. That is saying a lot.
What is an endotoxin?
An endotoxin is an immune compound also called lipopolysaccharide (LPS). LPS can cause inflammation and is a component of what’s known as gram-negative bacteria. Roughly 65–75% of the bacteria within the gut are gram-negative bacteria. Bacteria use LPS as an “adhesion molecule” to stick to and colonize the gut.
The structure of LPS can be important to determine its potential toxicity. LPS has a tail called the lipid A structure is the fatty acid portion of the LPS. The toxicity of the LPS is mainly determined by the types of lipid A components that it has. Some lipid A components are more toxic than others. Healthy individuals will have a low level of circulating LPS.

Endotoxemia simply means high levels of endotoxins, or LPS, in the blood. In metabolic endotoxemia, a person’s microbiome in the gut fails to protect the body from absorbing toxins during the digestion of a meal or snack. Studies of different populations across the globe consistently show that people in Western societies have microbiomes that provide weaker protection against metabolic endotoxemia.

What is metabolic endotoxemia (ME)?
Endotoxemia starts with a high-fat diet, or even a single high-fat meal. Digestion of high-fat meals can create a chain of events that both create endotoxins and allow them to permeate the gut barrier. First, the digestion of a lot of fat can cause gut dysbiosis — an imbalance of gut bacteria — which causes the opening of the tight junctions in the gut that should create a barrier. A high-fat diet results in a large die-off of gram-negative bacteria, leading the dead bacteria to release LPS from their cell walls. In this instance, the gut-body barrier is open and toxic LPS molecules — endotoxins — are floating around the lumen in the digestive tract and enter the circulation.

LPS shows up in the body’s circulation shortly after a meal, thus causing metabolic endotoxemia or postprandial endotoxemia. Once circulating in the body, LPS interacts with fat cells and other immune cells and creates chronic, long-term inflammation in virtually every tissue in the body. Unfortunately, the body takes a long time to recover from this.
What kind of fats cause ME?
Saturated fat drives metabolic endotoxemia the most of all fats. In fact, coconut oil is one of the most toxic versions of fats in terms of endotoxemia and has been studied in humans. The long-chain fatty acids in coconut oil — the lauric acid, for example — are extremely endotoxic.
Comparing different fats to a saline solution as a control shows both coconut oil and animal fat produce a higher endotoxin response compared to other types of fat. Cod and fish oil produce less of an endotoxin response than animal fat, and omega-3 fatty acids dampen the metabolic endotoxemia response. Vegetables oils are somewhat neutral compared to saline, though not if they are oxidized, which will produce a very high endotoxin response.
How do we know it is the fat content, particularly saturated fat content, of the Western diet and not the excess sugar? In a randomized study in humans, cream raised the level of serum endotoxin but a glass of orange juice rich in sugar did not. In fact, orange juice can blunt the rise in endotoxin that is released from a high fat, high refined carbohydrate meal.
Health implications of ME
Weight and metabolic diseases have a close link to endotoxemia. People who are obese, who have been overeating, or who are type 2 diabetic tend to have much worse endotoxic response than people without these conditions. This begs the question, does someone experience higher levels of endotoxemia because they are diabetic or obese, or does pre-existing endotoxemia contribute to obesity and diabetes? Several preliminary studies on the topic shows metabolic endotoxemia may induce obesity and diabetes.
Amongst non- communicable diseases, bacterial toxin translocation and intestinal permeability — leaky gut — is a leading cause of disability, mortality, and workplace absence worldwide. Metabolic endotoxemia has also been shown to lead to low testosterone levels and obesity in men, which reduces quality of life and increases risk of depression and heart disease.

Lowering ME With Probiotics
Scientists at the University of North Texas ran a pilot study with a spore based probiotic rich in Bacillus subtilis in humans. They measured metabolic endotoxemia in healthy subjects before and after a high-fat meal. After the month of probiotics, the participants showed a reduced endotoxic response.
After the pilot study, the team of researchers expanded the experiment to a larger, double-blind placebo study, published in the World Journal of Gastrointestinal Pathophysiology. Thirty days into the study, the group that received probiotic supplements saw a 45% reduction in endotoxins compared to their baseline following a challenge meal, while the placebo group saw a 28% increase in endotoxin levels. This preliminary result prompted the researchers to extend the experiment to 90 days.
Other blood markers showed a benefit from the probiotic treatment. After 30 days of probiotics, volunteers’ serum triglyceride levels dropped by almost 50 points, whereas triglyceride levels the placebo group remained the same triglyceride levels are a hallmark of ME.
Nutritional Treatment of ME
The rise in ME from high fat meals, particulary rich in coconut oil, can be addressed by changes in dietary choices. Avoiding high fat meals rich in saturated fats has been recommended as a strategy to avoid and resolve ME. These approaches has been reviewed in detail. A recent preliminary study found that pomegranates may offer some unique ability to lower ME. While not specifically studied in terms of endotoxin release, a whole food, plant diet naturally low in saturated fat would be an appealing route to avoid ME and may explain the lower risk of heart disease and diabetes. In a prospective study, a diet enriched with plant fiber, polyphenols and plant proteins was found to reduce ME and to induce favorable changes in the microbiome.
At the present time it is not routine to measure blood endotoxin or LPS levels. Inflammatory markers like the hs-CRP should be measured and reflect the amount of ME. The impact of dietary, lifestyle and supplement measures can be followed by a reduction in the hs-CRP.

@HeightOptimized ye spine grows last, taking peptides, hgh at late age could be beneficial. sleep stretch with relaxin is interesting too, might try myself if can find cheaper source as expesnive af, research more on sides may cause cancer apparently

@HeightOptimized very interesting but thisd cause very bad nausea possibly imo

@yerrag hey, just updating on my situation. its gotten quite better as of recent. i think it was acidosis due to respiratory acidosis( i used to do butekyo and that gave me the habit of short inhalations with small volumes of air, like maybe 30% of a full inhale), excess gut bacteria causing d lactic acid production indicated as i get white coating on tongue in the morning. for this ive been taking bicarb, inhaling more full volume of air slowly, around 5 secs inhale, carrot salad slowly kill off to avoid herxheimer reaction. planning to take mct, antibiotics like doxycicline soon however and then repopulate with kefir, probiotic after i look more into which bacteria is beneficial like boullardi, lactobacillus. i think small intestine should be sterile and then large gut have some bacteria but not too much, think losing bacteria could cause lactose intolerance, digestion problems maybe. i then take promethazine, ondansetron every now and then but not too often to create tolerance, maybe cannabis oil soon. also found avoiding empty stomach in morning, atleast eating a bit helpful. when i was younger tho i could do intense exercise in morning while intermittent fasting not eating much later without issue, if id do that now id get nauseous

@thyroidchor27 ye y do indians have good hair genes usually its interesting

@the-MOUSE also can mixing sugar and milk affect glycemic index? maybe makes it harder to digest the sucrose?

recommendations on diy drinks to make like maybe 2g sodium chloride, 3g potassium bicarb( or maybe other forms), 20g sugar drank throughout day as diy energy drink.

i have 20-40g sugar after waking and before sleeping.

50g dextrose working out. its mainly dextrose im inquiring for, think it can cause dehydration without electrolytes?

also thoughts max limit of dextrose/sugar in one sitting?

@Mulloch94 thnx bro. which form of potassium u reckon is best? im thinking potassium bicarb as can help my acidosis too. my serum hc03 has been 25, anion gap 19 for like a yr now.

mirtazapine might be pre good in my case, ill bring that up. i have some issues falling/maintaining sleep. low appetite. it appears it can cause fluid retention and swelling tho. idk much bout long term effects too as of now but definitely gonna research this further

i agree ginger is pre good, used to take that when i didnt have ondansetron.

im on ondansetron 8mg everyday rn for my persistent nausea/vomiting esp in morning but also throughout day. i think its safe long term, the qt risk is from higher doses? tmmrw meeting doc to discuss acidosis, potential further treatments like phenergan.

haidut suggested from this link
https://raypeatforum.com/community/threads/serotonin-endotoxin-pufa-as-primary-causes-of-depression-and-diabetes-can-be-easily-blocked.22823/post-328970

that

@haidut
"5-HT3 antagonists (ondansetron, tropisetron, granisetron, etc) "

Which one is the safest among above given medicines?

They are about the same in terms of risk. All of them have QT prolongation risks in higher doses but when used in doses recommended by Peat (1mg -2mg daily) should be pretty safe. Progesterone seems to reduce that risk further.
https://raypeatforum.com/community/threads/progesterone-reverses-the-side-effects-of-anti-serotonin-drugs-like-ondansetron.10554/

Palonosetron, Tropisetron however may be interestign alternatives as 5ht3 antagonists?

@yerrag completely understandable yeah its very different over internet text than in person with medical records etc. nontheless youve provided very good inisghts im grateful for and will bring up. i think it could very well be tied with this too, ive had lindsays nails for a substantial period now https://bioenergetic.forum/topic/266/do-you-have-lunula-on-nails/3?_=1708866810091

thats a good suggestion, to say family doctor from overseas told me this. ive never been on ssri, he just prescribed zoloft as he thinks its due from anxiety, without consideration of other underlying issues like acidosis indicated by anion gap etc. only real significant past medication id say was antibiotics and probiotics.

ill try ameliorate this with him and post further results if needed, maybe i could request more specific tests that can provide further insights.

@Hando-Jin
thank you, ive considered cypro but that lowers hgh and i want to take hgh peptides soon for possible late puberty masculiniation. ik its bad in short term, but im seekign to care about longevity etc after this first.

also heard cypro long term can have side effects. think itd be better for me to solve underlying issue acidosis causing this nausea rn.

rn i think maybe consider ondanesteron, Promethazine( esp this could help high ige maybe too) instead. @thyroidchor27 thoughts on Promethazine? i promptly got the idea from here of Antihistamines with antiserotonergic activity section. idk much bout this tho, maybe serotonin antagonists can have rebound/effects from long term use
https://en.wikipedia.org/wiki/Serotonin_receptor_antagonist#Antihistamines_with_antiserotonergic_activity
https://raypeatforum.com/community/threads/otc-anti-histamines-with-anti-serotonin-action.8588/#post-976641

definitely agree i got to ameliorate my current suboptimal thyroid. i think i can do it through addressing this underlying issue first before exogenous t3 maybe. but even so, yeah it could be quite beneficial to start t3 now

@yerrag thank you very much again for this very insightful response

@yerrag said in my recent subhuman bloodwork for recurring nausea/anxiety:

This relationship becomes disturbed when our body becomes very acidic and this is when our blood potassium becomes very high in potassium, which is our body's attempt to move potassium from its cells to its extracellular fluids, as reflected in plasma. Then the doctor will see that and tell us we have "too much potassium." And now we know that is nonsensical because we know better now. But in fairness to the doctor, he will just be exasperated explaining this to the average person.

yup, i had slight hyperkalemia in the past as well with accompanying high anion gap of 19. doctor just said lower cocnut water, bananas etc when i wasnt even consuming muhc potassium in diet. they were oblivious and overlooked acidosis. iron saturation was 27% but i think mayve improved as of recent as was 1 yr ago.

@yerrag said in my recent subhuman bloodwork for recurring nausea/anxiety:

But I am not sure as your blood sugar is not so high. It is only milldly high, and so it's possible you are metabolizing sugar well enough or that you're not eating enough carbs such that your intake of sugar/carbs is such that your sugar metabolism is not really put to the test. Are you on low carb, or keto, or carnivore diet or doing intermittent fasting? As using these methods are a poor substitute to deal with having a faulty sugar metabolism.

i unwittingly intermittent fast, low carb sometimes due to low appetite and nausea. esp of recent this has been exacerbated. mayve affected this recent blood test too, days prreceding this blood test i would have only 1-2 meals a day rlly. even today i could eat very little, which then in a negative feedback loop caused me to vomit out the little i did eat. im recovering rn just thru mix of salt/sugar drinks. today i tried BRAT diet for nausea as was especially nauseous and low appetite eating just banana, 2*20g pea protein, 500-1000g salt drinks throughout day, 2 slices bread, carrot salad with coconut oil i still vomited. but in part i think psychological factors could be playing significantly as well in addition. think i notice these especially spur up when i feel high serotonin, low t, anhedonic. rn trying meditation for that i guess.

also another thing is i usually wake with a white/green coating on back third of the tongue. think it could be due to my diet which rn is like oats with cocoa powder, extra virg olive oil, banana in morning eaten slowly like 1-2hrs. i eat slow due to nausea and in general im just unable to eat quick. i think fibre in morning helps me, i vomit if i have plain orange juice/milk in morning. then sugar/pea protein drinks throughout day, lunch/dinner of rice with fatty gelatinous lamb, extra virg olive oil. on days im nauseuous ill usually just have liquid meals of sugar/protein every few hrs until it settles a bit around later in day and eat rice/lamb.

thiamine ill improve through nutritional yeast flakes i think. yeah i dont think i consumed much of this.

ill heed your suggestions and update how it goes. ill be visiting the doctor in around 4 days, ill try to suggest to him this could be due to acidosis, than him suspecting just anxiety and prescribing ssri.

doing some self research i think ye it seems to be lactic acidosis
https://en.wikipedia.org/wiki/Metabolic_acidosis#Causes

treatment they dont suggest much apart from taking bicarb
https://en.wikipedia.org/wiki/Lactic_acidosis#Treatment

looking at causes could maybe give more insights to treatment methods, fixing underlying causes. like ye it lists thiamine deficiencies as you stated, Impaired delivery of oxygen to cells is interesting too, i mayve unwittingly induced this from butekyo
https://en.wikipedia.org/wiki/Lactic_acidosis#Causes

@yerrag thank you for this reponse truly, you mayve pinpointed something i wouldve never found otherwise. metabolic acidosis could definitely seem the culprit aligning wiht my current syptoms.

idk why it wasnt tested again this time, but my ferritin was very low at 34 around a yr back, although other iron markers were fine like tibc, saturation etc. i took ferrous fumarate, increased red meat intake for this. my calcium appears a bit on the high end too currently, in the past it went beyond reference ranges due to long time in sunlight without k2, if this info may give more context. my case is very obfuscating and complex, esp im just 20yo layman newbie all this and even doctors seem unaware.

i might be a carrier for cystic fibrosis which can allegedly possess symptoms altho not to as great of a severity as actually having cystic fibrosis. i was never tested but have noted salty sweat, aquagenic wrinkling of palms, absence of lunula on nails, thick mucus/dry mouth on workouts( but ive only found out all this recently in past 2 months, importance of electrolytes, in past i drank alot of water with little electrolytes). would wake with yellow piss, but throughout day piss was often clear. another piece of info which may be inked due to defective chloride ion transport channel found in CF.

unfortunately i dont have the ECG graphs but may try request it and if so ill get back to you. ill perhaps copy paste ur response to my doctor as well. unfortunately hes a bit dismisisve tho, like when i bring up stuff hes like nah mate thats fine without further thought like when i inquired about SSRIs etc. but health is priority, short term embarrasment is necessary worthwhile cost.

i have no edema at all, body is quite vascular except for my face, even when i was at low bodyfat earlier i had bloat in face. could be attributed to high TSH however. past tests i was definitely hypo, very low bmi with caloric restricted diet devoid of essential nutrientd. as of recent ive been on pro metabolic diet so i was suprised by TSH of 3.1 but it could be one off affected measurement due to low calorie, high cortisol, vomiting in days preceding to test.

i think with all this, maybe somthing to consider that could ameliorate these then would be to increase intake of iodised salt and bicarb soda. possibly im going to start potassium chloride powder too in my homemade electrolyte drinks for the day.

idk if related but another thing in this post i forgot to mention, sometimes when sunbathing i get panic attack like symptoms, palpitations and nausea subsequently. but the uv is often quite high in my location and i do it for a fair amont of time until i begin sweating.

imgur is multislide, lmk if theres issue viewingn it. may be some redundant info/tests can just skip. rightmost side is most recent results as some tests have results from earlier sessions. here is results, may need to click image to view fully some:
https://imgur.com/gallery/jGT4wF9

results were quite bad, but keep in mind prior days i felt quite shit as due to nausea didnt eat much. and on the day getting test in afternoon( i wake late usually so it was half hr after waking i did it) especially felt high cortisol, hypo, cold, fatigued. was pre dehydrated, they had trouble drawing blood multiple times in fact
https://bioenergetic.forum/topic/827/why-do-i-have-low-appetite-and-nausea-in-morning?_=1708582100490

another past maybe related thread
https://bioenergetic.forum/topic/784/why-is-my-piss-always-yellow-dark-brown-in-morning-despite-being-hydrated-in-night-day/13?_=1708582100493

doctor told me to come back after a week telling me to take Sertraline jfl, but no, i dont think i will. i seem good candidate for cypro but idk if should ask that as reduces hgh and im starting peptide cycle soon, i may just stick with repeat ondansetron. or could continue high gi diet while on cypro maybe as didnt affect igf1. https://pubmed.ncbi.nlm.nih.gov/19618661/

so ye any thoughts what to do. rn im considering gut detox to lower serotonin thru carrot salad, activated charcoal. i had prior antibiotic and probiotic, potnential sibo maybe worsened with high carb, low fibre too jfl. it hink this is due to high serotonin, dehydration( this i can fix easily from now on tho), maybe high histamine too as i exhibit lot of signs that personality, high IgE in blood, idk about dopamine tho i feel adhd, anhedonic, unmotivated often. https://testonation.com/2020/01/03/the-high-dopamine-histamine-personality/
https://testonation.com/2018/03/17/serotonin-60-ways-to-lower-it/

maybe due to increased stomach acid in morning too from skipping meals.

i vomited blood mallory weiss tear last week too so he suggested rlly got to control, mitigate this from now on. lowkey contemplating sui coz of this too ngl. its maybe ovER @thyroidchor27 @haidut

@yerrag these r my recent results btw maybe some more insight. can skip redundant info/tests https://imgur.com/gallery/jGT4wF9
https://bioenergetic.forum/post/9421

@Ecstatic_Hamster thank you for response. im too low iq to comprehend it tho ngl, so i just smoke cannabis?

95.7f. he doesent reveal numbers but even like 3 TSH docs will consider in range. https://protocol.bryanjohnson.com/Monthly-Notes