@Uncover said in Open-label trials - how is this allowed?: The most fun part about it is there is awlays something to learn even when I think im almost done I find a new part of the puzzle Yeah, I've similar feelings here - it's probably nested like a Russian doll... One can think that he is out of the cage, but then turns out one is still inside a bigger cage... & @MarkusAllenUSA Regarding Open-label trials - besides what has been already written - and I agree with, another reason is that they are simply cheaper... And knowing that double-blind study can be sophistically manipulated too, then what's the difference? https://medium.com/@vohchenwei/the-risks-and-realities-of-data-manipulation-in-clinical-research-a-critical-analysis-for-medical-aea5d9207887 Especially knowing that today most researchers are not aware of the limitations of their own work... Ray wrote about this: https://raypeat.com/articles/articles/authoritarians.shtml https://raypeat.com/articles/articles/adaptive-substance.shtml https://raypeat.com/articles/articles/intuitive-knowledge.shtml

@yerrag Sorry to hear about your troubles, I wish you well and a quick recovery! Never trust GenAI about nuanced, subtle, or fuzzy topics. GenAI doesn't think or reason; it just makes statistical inferences between words. In technical terms, fennel seeds can increase serotonin, but practically not - the amounts are insignificant! (It is about weak MAO inhibitions) https://pmc.ncbi.nlm.nih.gov/articles/PMC3521852/ The most probable mechanism is significantly increasing GABA, which should help with deep sleep. https://ppj.phypha.ir/article-1-664-en.html BTW be careful with fennel it can also increase estrogen... Substances known to potentially lower serotonin: S. Boulardii, lavender, Shilajit, beta-alanine, Ca, Mg, glycine, lysine, Tyrosine/DLPA + BCAA, Aspirin, vitamin B9, B1, quinones, caffeine, creatine, Schisandra, inosine, theanine, propolis, Siberian ginseng, PRL-8-53, LSD, and Manganese; avoiding PUFAs…

Two more months have passed. Healing from the thing in September was very slow, until I realized cutting down on nicotine was a good idea. Now limiting nicotine to after eating. Still not doing great, my body just doesn't seem to function very well. Trying to reintroduce things (like ketchup) made some symptoms come back, and then it's back to slow healing from that. At least now it's obvious that gastritis has been a problem all along. Definitely not doing as great now in fall and winter, although B vitamins seem to keep me going somewhat. No appetite, losing weight, no libido, barely enough energy to keep up with I need to get done, let alone having any energy to enjoy my free time. Is chronic gastritis enough to explain most of this, I don't know. Feels a little bleak. Considering trying an H2 blocker, just accepting being exposed to the excipients. A good thing is eating soft bland food has practically gotten rid of the constipation problem. I had been eating carrot salads for a long time out of pure inertia but they were actually constipating. Endoscopy coming up in a month.

@DavidPS Holymoly

@cs3000 said in Muscle twitches/acute “cramps”. Help appreciated: @ejmcc27 generally a sign of lower atp / hypoxia (eyelid is very common place to get twitches 1 area that shows hypoxia & hypothyroidism obviously, e.g darkens or droops down, with very high usage. atp is used in reversing muscle contraction, with twitches the muscle is failing to stay in the relaxed state), could try stopping vitamin D and limiting UV light for a few weeks to confirm if its that making it worse. thats what i found. + eating more calories if you have low intake (fat release of stored vit d otherwise). in poor health vitamin D can excessively convert to a form that inhibits mitochondria. it could be from a range of things causing the hypoxia / lower atp though I don’t believe/show signs of being hypothyroid. But will try to limit vitamin D and see what happens.

@Uncover i usually go to that island that is close to bangkok koh samui iirc. thanks for the info. bkk is super cool

@happyhanneke For cynomel weigh out 10-20mg to get that 2.5 to 5mcg range. And with cynoplus make sure the doses don’t exceed 10mcg of t3 per dose. So 53mg of cynoplus max in a dose. Even less is probably better, splitting it up throughout the day.

@bantoidbelittler aspirin (with vit K and dissolved in baking soda). Danny calls it the Swiss Army knife of health and I’ve really come around to it myself.

@Rah1woot the video recording to view the relaxation reaction speed sounds like a really good idea, more data points sounds better than less

@Mauritio There are diffusers that only use the oil

@Dibodibo said in Help finding cancer info: I need a link to Georgi's study on B1, B3, B7, and aspirin curing cancer. Hi, I haven’t got the link of RPF but here is some info from the old RP forum. See last one. https://raypeat2.com/articles/articles/the-cancer-matrix.shtml https://raypeat2.com/articles/articles/leakiness.shtml https://raypeat2.com/articles/articles/cancer-progesterone.shtml Here is a link for Haidut site (no particular subject on both elements) http://haidut.me/?s=cancer+aspirin+and+vitamin+B http://haidut.me/?s=cancer+aspirin+ Here is the link you asked for, I suppose. A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma https://bioenergetic.forum/topic/6/a-combination-of-vitamin-b1-b3-b7-and-aspirin-has-curative-effects-on-human-mantle-cell-lymphoma => Human-equivalent doses for the substances were ~15mg/kg vitamin B1 (thiamine Hcl), 30mg/kg vitamin B3 (niacinamide), 1.5mg/kg vitamin B7 (biotin), and 15mg/kg aspirin. Administration was once daily, orally. Link given by Haidut on bioenergetic.forum https://twitter.com/haidut/status/1751716166387597730

It doesn’t sound fancy but just eating regular balanced meals throughout the day is the main way out. Reverse diet to find a good high maintenance calorie and be consistent. You don’t have to rely on reheating potatoes all the time either. Add in more sugar sources like from fruits, dried and juiced.

Another article related to cardiac fibrous. The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review Fibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure. Interleukin (IL)-11 is regulated in various heart diseases and has recently been reported to be an important cytokine in fibrosis in this organ. However, this topic has been little explored, and many questions persist. Thus, this systematic review aimed to report on possible IL-11 therapies evaluated in rodent model-induced cardiac fibrosis.

@happyhanneke nice. Consider researching sodium thiosulfate and see if that can be added to the dmso for benefit. It’s one of the least spoken of supplements in the bioenergetic community for some reason, but Ray spoke about using. It is a powerful decalcifier.

@yerrag Yeah I would describe myself as acidic now. I have really bad sleep and low t so that adds to it. So I should check creatine clearance test, check pth vit d and ionized calcium? I want to see if the kidney or PTH came first. I do think PTH is more likely but I wonder if it is curable naturally once I get DJS and am able to get a goods night sleep and low stress. However if its a ademona n the PT then I would assume not? My salvia feels thick and sulphury and I would call it a unquenchable dry mouth/thirst. If I don't drink water I get a burning in my right side. I also have very foamy urine I am worried it is something more severe such as cancer etc. If it is I will use it as a opportunity. I am going to get blood drawn again in a week or so so ill make another thread then. I also am going to chec t3 t4 and some other things

@functionalgirl As aspirin (acetyl-salicylic acid) and salicylic acid are only weakly soluble in water, you could use the form of sodium salicylate instead which is very water soluble and available in pure powder form online.

My sincere congratulations to all USA citizens! I'm happy for you and hope that the EU will follow... [image: 1731620410867-53cfdd59-5c80-49db-9c47-b53d8fc1a241-image.png]

From RP: When cells are stimulated, they adapt, with substance flowing into complexification until an approximate, appropriate equilibrium is reached. Stimulation is a need, and an opportunity, for adaptation and differentiation. If there is a need for adaptation, without the necessary substance and energy, the cell or organism will either deteriorate or withdraw. Energy, structure, and carbon dioxide: A realistic view of the organism Ray Peat Discussion in 'Articles & Newsletters' started by mas, Mar 8, 2014. https://raypeatforum.com/community/threads/energy-structure-and-carbon-dioxide-a-realistic-view-of-t.3344/#post-39530