Nutritional deficiencies in iron overloaded patients with hemoglobinopathies Low serum 25-hydroxyvitamin D in hereditary hemochromatosis: relation to iron status

@Galaroc said in Niacinimide for PUFA depletion: Hello gentlemen, I am currently in Guatemala and am living with a host family. Trying to keep peaty and am managing well but PUFA intake is currently non-zero. Have access to aspirin but not K2 and therefor hesitate to blast a lot of it to mitigate the PUFA I’m taking in. I am interested in niacinimide as an option for mitigation. I have some energin with me and have been using it regularly (I am totally yellow) but I’d like to explore niacinimide specifically. Anyone have recommendations for brands/dosing/overall protocol for PUFA depletion and management? Ray Peat preferred smaller doses of niacinamide taken more frequently. I currently take 100mg of niacinamide, 4Xday. Niacinamide is water soluble so it only stays in the body for a couple of hours. I use the purebulk.com niacinamide. Another thing that Ray Peat suggested taking is some vitamin E. Perhaps somebody can chime in regarding the amount and the timing? I think the goal is to get the vitamin E into your stomach at the same time as the ingested pufa so it can saturate it and make it safer. Sorry, I don't know the amount of vitamin E needed. I suspect a small dose though. Maybe you can find info about it here.

@bubble Hmmm. That's puzzling. I know that drip coffee is often ground when it is packaged and that pre-ground coffee often harbors more mold than packages of whole beans.

@yerrag thanks alot, for me i love these little maticulus details

amazing results, congratulations. the fact that you have maintained muscularity while switching to gelatin as your only protein source is great. the loss of strength in the gym is probably more due to eliminating starch more so than anything else, but maintaining or improving muscularity and body comp is a big win, not to mention solving the prior health issues. i'm not sure what you can do in terms of rounding out your protein intake with complete sources if dairy, meat, and eggs are problematic. peat has spoken favorably of certain foods outside of these 3 varieties having really good quality protein like potatoes but throwing in 2 pounds of potatoes (peat said this is similar to around 1l of milk in terms of protein amount so about 35g) is probably less ideal than your current scheme which seems to be having a small amount of beef for dinner on occasion. with that said, i think you have the correct idea with how you might use a little bit of beef for dinner, i might recommend experimenting with different cuts to see which ones are more agreeable or less likely to cause issues. i've done remarkably well in the past by using a high quality mince beef while dealing with autoimmune type issues, it's not the worst cut as there is a fair bit of connective tissue in there, but you might be well to experiment with some more gelatinous cuts like lamb shank. you can also make a gelatinous stew using oxtail but i never tried the stuff myself.

Plow a non-white bitch, and you can last for days.

Ray Peat on Nitric Oxide

As mentioned above, try the different types of Thiamine (TTFD, Bento, HCL)

unhomogenized goat milk was the most agreeable but i could never get dairy digestion to the level i wanted it and i suspect the connection between thyroid and dairy intolerance being the cause for myself. this was after trying whole milk, skim, a2, "lactose free" a2, unhomogenized goat milk, etc the protein in goat milk tends to be more agreeable (doesn't produce β-casomorphin-7) which can have an impact on digestion, but this doesn't really matter that much as you can just drink a2 cow milk. some posit that goat milk having smaller sized fat globules makes for easier digestion. for myself, trying every milk variation looking for the solution was a bit of cope when the fundamental issue is thyroid it seems. if you address that and dairy digestion becomes agreeable, you can't go wrong with rays recommendation of skim or low fat milk, anything without fortified vitamins or other nasties should work nicely. my own TSH has been trending upwards for some years now (the top end of the reference range for normal limits is comically high). ray i believe said for a healthy person TSH should be below 1 and anything above that is a sign there could be impaired metabolic health. pulse is important in this context as well because there are other factors that can suppress TSH so you need to check other markers to get a good picture here of your metabolism.

@Grothendieck UR welome

@Kvirion Its not dessicated its frozen

@yerrag said in Just found out I have reactive hypoglycemia. What now?: Those raccoons also feast on koi in Singapore. I don't have that problem here in our overcrowded Manila. I have a mind to move to the mountains, but when push comes to shove, I procrastinate because the idea on becoming a nomad appeals to me as well. Decisions, decisions.... I moved here from a big metropolis in 1981. I went through a bad divorce (is there any other kind?) and decided to get out of Dodge when the divorce was finalized by the Court. It was the best decision I ever made (next to that divorce). It was an amazing little town in the early 1980's. Nobody locked their doors; they kept their keys and money in their vehicles (unlocked). If a stranger needed a ride to somewhere, people were known to just hand them the keys and say, "Here, take my truck." People were so scarce in the county back then that everyone always waved when passing another vehicle on the road, acknowledging the other human being. The times have changed the place; too many tourists now. I miss my little town.

@Peatriot Thanks, I am thinking that too now.

I would second the idea to only take antibiotics as needed. There are many antimicrobial options that don’t carry the risk of upsetting the balance of organisms or causing overgrowth in less desirable organisms like fungus/mold/bad bacteria like c diff.

I've had knee pain my whole life, but am now free of it. I switched to barefoot shoes and after a while of adjusting, my pain just went away. I like barefoot shoes a lot, because you feel more connected with the ground/world.

@Not_James_Bond thanks for the reply! Very interesting, and I can see how it would become necessary based on this. Did you look at Dr Lonsdale’s work in conjunction with your experimentation? I’ve come across his work before but I don’t think I understood how essential B1 is in my own personal context.