@eric said in Are zyns Peaty?:

Georgi went into nicotine in detail in an old GE episode. The summary was that nicotine is a mixed bag and is ultimately not peaty. I'll try to find it.

found it (may be errors in transcript)

I wouldn't use nicotine long term. I think nicotine has some great advantages short term. It is an aromatase inhibitor. It's a monoaminoxidase type B inhibitor. So in other words, you will lower estrogen and may increase. It will decrease the degradation of dopamine, right? But it also releases free fatty acids, and it's pretty effective at that. And it has a potent pro-adrenergic effect. And it's also like basically acts as an agonist of the acetylcholine receptors. So this in the long run actually has really detrimental effects. And they outweigh the positive ones. And ironically actually, despite the fact that smoking cigarettes has other and more dangerous. So overall, cigarette is ironically like a stronger carcinogen. But systemically for the health is better in the sense that it has additional components there that mitigate somewhat the negative effects of nicotine. So, but if you only use nicotine, it's not a carcinogenic. But I think over time, it really targets the brain and the elevated free fatty acids. It basically raises your metabolism in a bad way. It mimics exhaustive exercise. You're going to get the same adrenergic slash cortisol response if you run for like, I don't know, five, six, ten miles.

From Generative Energy #05

@cornwallis

I purchased doxycycline tablets from Mexico, only one box of 10 tablets. I experienced with several low doses, and can recommend staying below the 40mg to avoid development of bacterial resistances.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421036/

I experimented with the following dosages:

On the first day, I took half a tablet (50mg) and experienced slight intestinal discomfort.

This prompted me to reduce the dose to 25mg once every 24hours. After about 2 days of this I increased the dosage to 25mg every 12 hours, this was in an attempt to keep reducing the bacterial load at a steady pace. Keep in mind I did this without any advice or instruction from any doctor or medical expert.

I ended up only consuming about 225mg total, and have 7.75 tablets left over.

I would recommend staying upright during the first 20-30minutes of consumption and if you can handle it, on an empty stomach. Make sure to be careful with sunlight exposure as doxycycline can make you very sensitive to sunlight exposure.

@lucasmenem said in Cerebral thiamine, what you know?:

excellent information, thank you very much

You're welcome. I'm glad to try to help by sharing info about my own health journey.

I've posted more info about thiamine recently on this thread

@shedim I can't breathe when

@fd It is possible for sure but probably unlikely with doses lower than 5mg a day

@PissBoy It's about restricting the activation of the cholinergic system by protecting yourself against patterns of learned helplessness. You could try and visualise sodomising your school's faculty. Ray and Georgi talked about this.

The dark side of stress (learned helplessness) - Ray Peat
Intelligence and metabolism - Ray Peat
How do you know? Students, patients, and discovery - Ray Peat

@Cearrson Hi, I suggest that the positions in which you instinctively sleep are potentially better in many cases, sleeping on your back is not better in itself, I have observed several people who snore and have sleep apnea on their backs, and when I suggested that they sleep on their sides and / or reduce their number of pillows and they instinctively began to sleep more on their sides, they no longer snored and no longer had sleep apnea

@PissBoy I was starving all the time, but I also drank insane amounts of coffee which worked as an appetite suppressant.

@skylark yes I have talked about this before with my friends and family (another sound that I dislike very much is styrofoam, though not as much as Velcro, which even thinking about it now makes me wince in pain) — and the only person who gets me is a close friend of mine who told me that he hates the sound of metal grating on metal and told me that his dad and brother share similar things, and he said something about overstimulation and autism, which runs in his family.

Sounds like re-peat. Which is really what most have been doing. Just ray-peating everything he said.

Names matter. Literally. It’s part of the key to understanding our reality.

@yeezy both sound good. Experiment!

@HoldenCox I take it sublingual

@hypermensch I had this for many years, it's something that got solved over a long period of time, so it could have to do with a variety of factors, but I woul say the main way to go about relieving it quickly would be lowering endotoxin (DAILY carrot salad, limitation of starch consumption), increasing calcium, and using beneficial things like aspirin and progesterone.

When you’re cutting, either from restricting calories or preferably by raising the metabolic rate, you’re going to have less energy in the system and most facets of health will suffer. Focus on lowering stress and increasing youth-promoting hormones like thyroid, progesterone, pregnenolone, DHEA before and during the cut. A clean bulking phase followed by a shorter cutting phase serves well to bolster nutritional stores prior to the cut. In the cut, I would increase ratio of carbohydrates to protein slightly and prioritise gelatinous sources of protein over muscle meats. I would also focus more so in concentric loading of muscles during training. This is to lower inflammation while maintaining muscle mass during the cut.

50-100mg pregnenolone with 400 IU Vitamin E.

I have unusually low temp usually but if I take this, my wife starts asking me whether I'm sick or have a fever. It's very effective.

The Wim Hoff cold plunge training guys are saying the health benefits are because of the adrenochrome produced.
True?

@A-Former-User said in How to lower Adrenaline:

I remember from the RP Forum that you're a huge fan of thiamine and convinced that thiamine deficiency is behind most people's problems. I'm not so sure about that. The list of symptoms of thiamine deficiency is basically every symptom under the sun, and I know that Ray Peat was never terribly convinced that thiamine was the be all and end all. I asked him about it once and he said it's most likely hypothyroidism. He advocated for dosages between 10-100 mg a day. There is a very long list of people who believed they had beri beri and started taking high dose thiamine and experienced nothing but misery and a host of new problems, which I know the thiamine cheerleaders simply call "the paradoxical reaction" (or something to do with methylation or not having the right co-factors etc), but it never went away and they had to give up. They're in a facebook group and it's depressing reading. Do me a favour mate and PLEASE don't spam every thread on this new forum with the beri beri guff!

I should just ignore you because you are being a first class jerk. But I've decided to respond instead.

#1: Ray Peat recommended thiamine quite a lot actually; he just never wrote a full article about it. Here are a few links for your consideration:

Thiamine mentioned in Ray Peat's written work

Vitamin B1 (thiamine) mentioned in Ray Peat's written work

Thiamine mentioned in Ray Peat's audio interviews

Vitamin B1 (thiamine) mentioned in Ray Peat's audio interviews

#2 This forum is named the Bioenergetic Forum for a reason.
https://www.nature.com/subjects/bioenergetics
"Bioenergetics is the branch of biochemistry that focuses on how cells transform energy, often by producing, storing or consuming adenosine triphosphate (ATP). Bioenergetic processes, such as cellular respiration or photosynthesis, are essential to most aspects of cellular metabolism, therefore to life itself."

Ray Peat focused a lot on the concept that if cellular energy is optimized then health follows.

It will probably come as a shock for you to learn that thiamine is required for cellular energy. Thiamine acts as a co-enzyme in several steps in the Krebs cycle which is how cellular energy (ATP) happens.

The importance of thiamine (vitamin B1) in humans