@ThinPicking I'm kind of reminded of the way in which Georgi treated mice with, I think it was B1, B3, B7, Aspirin to reverse tumor growth. If tumor growth can be considered a problem of "de-integration" of cells per Warburg (in my head, this is cells "ceasing to trust" the body to provide for them and making do on their own), could "penumbral" brain tissue be brought back into integration in a similar way?
Solving the problem of blood and fluid flow would seem like the important thing. Michael Levin's work in bioelectric organization may be applicable.
https://www.youtube.com/watch?v=OD5TOsPZIQY
The biology stuff in above is interesting. Reminds me of Mind and Tissue by Ray Peat.