Reasons for longevity in Japan?
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I’ve only read the second link (Dr. Saul Newman). Rather cheap. I summarize: Those people have no birth certificate; so no proof for old age. The rest is blabla.
But “we” are shooting the wrong target: It’s not about centenarians (100ies) but about old aged persons fit and well in their body / mind, still active at 80ies.
Only logical.
Take this example: In Okinawa: Most people were fit in their old age but when the Americans arrived with coke and burger, the natives began to eat manufactured food. They became then obese at 40ies... -
@DavidPS
Good find. How useful and practical would it be to take inhibitors every day to reduce hyaluronidase if HA reportedly only has a half-life of 1-3 days and wouldn't it be better to raise HA synthesis rather than block its degradation?
Is there decreased HA synthesis or increased HA degradation with age? And why so?
I see genistein as a related flavone inhibits the enzyme HA synthetase 2 through protein kinase - making it important to check if any of the other substances listed in the table above do the same. Similiar to how aromatase inhibitors often act as xenoestrogens themselves and therefore result in no overall benefit. -
@CrumblingCookie - I do not think that HA is the main reason for the longevity of the people in the videos. I think the videos were designed to sell supplements. However, HA will contribute to their youthful appearance.
List Of 15 Foods High In Hyaluronic Acid
In addition, I eat foods high in apigenin. See figure 2 in Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)
Eating healthy whole foods is important.
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541) 👀
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@DavidPS said in Reasons for longevity in Japan?:
@CrumblingCookie - I do not think that HA is the main reason for the longevity of the people in the videos. I think the videos were designed to sell supplements. However, HA will contribute to their youthful appearance.
List Of 15 Foods High In Hyaluronic Acid
In addition, I eat foods high in apigenin. See figure 2 in Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)
Eating healthy whole foods is important.
Coincidentally, and anecdotally, my brother, who abuses his body with drink and little sleep, has skin that looks better than it should, for all that abuse. And the two things he eats a lot of, are #1 and #2 in that second list you provide: grapefruit and clementines. He will mix up the clementines with tangerines and mandarins (which maybe have the same nutritional value, idk).
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@Luke I think 3 of the main factors are
1, high ergothionine intake (mauritio has a post on that),
2. a more relaxed way of being, (generally, outside of anime studios) (maybe helped created by high % of elderly population)
3. lower rates of vaccination since the 70s after children died from them and a bunch of lawsuits hit creating a more measured approach (especially with mercury being used for a while & aluminium creating extra toxic burden) (only two new vaccines were licensed in Japan between 1990 and 2007 compared to 17 in the US)https://www.youtube.com/watch?v=RfHTcloRdIU 97 year old running a restaurant (humans in true form)
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
https://substack.com/@cs3001 -
@cs3000
Thank you. Here is the thread if other people are interested: https://bioenergetic.forum/topic/1799/ergothioneine-amino-acid-for-life-extension/14?_=1736257389403 -
Using the macro visualizer by @exfatloss you can see that 1950’s Japan and Okinawa diets consisted of shockingly high carb intake (80-85% of calories) Coming from mostly white rice and sweet potatoes. This means they ate a very low-fat (low pufa) and lowish protein diet particularly methionine/cysteine/tryptophan. This could contribute to their longevity and leanness.
The earth speaks to us all, Just listen
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@Serotoninskeptic
Wow, that is so interesting!Looking at the macros, they ate a very, very good diet.
In the methionine thread I've written about high carb, low protein, low fat probably being the ideal diet (but restriction 2 macros is hard) and that is pretty much what the Okinawans ate !
That also gives credit to the low protein idea being sustainable long term. Around 10% protein is what they use in a lot of studies, so that seems to be a good goal."Key nutritional biomarkers for longevity among Okinawans include lower levels of homocysteine and higher levels of antioxidant vitamins, ..."
https://en.m.wikipedia.org/wiki/Okinawa_Centenarian_Study
--> both could result from a low protein dietIirc they also have/ had higher androgens and androgenic Features than other Japanese ethnicities.
This study shows Okinawan men have higher testosterone but also higher estrogen than American men.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8496353/Dare to think.
My X:
x.com/Metabolicmonstr -
Blue zones are just a BS myth...
https://youtu.be/rB4lhT71SLo
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https://www.dailymail.co.uk/wellness-us/article-13023311/blue-zones-healthy-life-bogus-fake-birth-certificates.html -
@Mauritio @Serotoninskeptic nice insight ty
Japanese and Okinawans were similar for averages (Okinawans had less disease too though) doi: 10.1196/annals.1396.037
(average, maximum) for Okinawans (83.8 years, 104.9 years) compared to other Japanese (82.3 years, 101.1 years),
nearly 1/2 the pufa intake , relatively high for fat % but they also ate 16mg vit E which helps counter pufa vs 6mg with the other japanese (less vit E with more pufa). 9% protein & 13%.
check this https://journals.physiology.org/doi/full/10.1152/ajpregu.00834.2004
(^ I wonder if there's some exponential element to vit E need for higher pufa intake? other studies havent replicated that with lower, and their diets typically high in pufa. but rats are usually fed high vit E as a baseline already.
extreme dose not needed to counter a lot of the pufa, especially with lower intakes seen here. both also ate >200mg vit C too i think which helps vit E function, if the other japanese ate 16mg too would it have closed the disease gap a lot? which was still much better than usa)Around 10% protein is what they use in a lot of studies, so that seems to be a good goal.
this was a good one, with 10% fat and ~80% carb diet (13% as sugar), (7% protein vs 13% vs 7% + bcaa,
they added 1.8g l-cystine to 70g casein (casein doesnt have much as only protein source, some cystine needed e.g for the sulfur reactions)(mrna expression, in liver)
https://pmc.ncbi.nlm.nih.gov/articles/PMC6073443/#sec5-nutrients-10-00918
so 10% protein in the middle would still give a fgf21 ucp1 boosttheir lean mass & bone gain suffered on 7% but some gain
yeah bumping up to 10% might be best of both
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@Mauritio @Serotoninskeptic @cs3000
When Lindeberg examined the Kitava diet, he noticed they had a similar macronutrient ratio: ~ 70% carbs, 20% fat, 10% protein. Some fish and coconut, but mostly starchy tubers and fruit.
Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.
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Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.
Could it have been the Tukisenta?
"The diet of the Tukisenta in New Guinea was studied in 1973. Their diet consists almost entirely of sweet potatoes. The Tukisenta were lean, healthy, and had little to no sign of heart disease or other diseases of civilization"
The earth speaks to us all, Just listen
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@Serotoninskeptic said in Reasons for longevity in Japan?:
Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.
Could it have been the Tukisenta?
"The diet of the Tukisenta in New Guinea was studied in 1973. Their diet consists almost entirely of sweet potatoes. The Tukisenta were lean, healthy, and had little to no sign of heart disease or other diseases of civilization"
Could be. I found the interview (part 1, it starts at 16:25): https://oneradionetwork.com/dr-ray-peat-ph-d-answering-a-plethora-of-questions-regarding-health-diet-and-nutrition-january-1-2014/
Altough I didn't understand what he was saying. Something with ...inions?
Edit:
Here is another one, starting at 01:13:00. That was the interview I remembered: https://oneradionetwork.com/dr-ray-peat-ph-d-got-milk-milk-is-a-good-food-really-july-18-2019/Pacific islanders, so could be Tukisenta.
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I am wondering if a large part of their longevity is related to the rich soil shown in the Connie Chung videos above and natural water shown in the video linked by cs3000.
Bruce Ames has a triage theory of aging.
Abstract
Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541) 👀
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@DavidPS I noticed also in a few of the so-called "blue zones" they are drinking mineral-rich spring water that's been filtered through limestone rock, resulting in high mineral content, particularly calcium and magnesium, due to the limestone's composition. Specifically Nicoya, Costa Rica which has a high concentration of this mineral-rich limestone. Their traditional diet is also low-protein and consists of primarily peaty foods. Nixtamalized corn, black beans, yams, white rice, tropical fruits. The black beans are notably low in pufa compared to other legumes as well.
Soybeans: 5.1g/100g
Chickpeas: 2.7g/100g
Kidney Beans: 0.3g/100g
Pinto Beans: 0.2g/100g
Black Beans: 0.1g/100g -
Here is a link to a photo of Connie Chung (born 1946) and her husband Maury Povich (born 1939). The photo was taken in 2023. From the photo, do you think that she is using the fountain of youth molecule that she shilled?
