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    Reasons for longevity in Japan?

    Case Studies
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    • MossyM
      Mossy @DavidPS
      last edited by Mossy

      @DavidPS said in Reasons for longevity in Japan?:

      @CrumblingCookie - I do not think that HA is the main reason for the longevity of the people in the videos. I think the videos were designed to sell supplements. However, HA will contribute to their youthful appearance.

      Foods High in Hyaluronic Acid

      List Of 15 Foods High In Hyaluronic Acid

      In addition, I eat foods high in apigenin. See figure 2 in Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)

      Eating healthy whole foods is important.

      Coincidentally, and anecdotally, my brother, who abuses his body with drink and little sleep, has skin that looks better than it should, for all that abuse. And the two things he eats a lot of, are #1 and #2 in that second list you provide: grapefruit and clementines. He will mix up the clementines with tangerines and mandarins (which maybe have the same nutritional value, idk).

      "To desire action is to desire limitation" — G. K. Chesterton
      "The true step of health and improvement is slow." — Novalis

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      • cs3000C
        cs3000 @Luke
        last edited by cs3000

        @Luke I think 3 of the main factors are
        1, high ergothionine intake (mauritio has a post on that),
        2. a more relaxed way of being, (generally, outside of anime studios) (maybe helped created by high % of elderly population)
        3. lower rates of vaccination since the 70s after children died from them and a bunch of lawsuits hit creating a more measured approach (especially with mercury being used for a while & aluminium creating extra toxic burden) (only two new vaccines were licensed in Japan between 1990 and 2007 compared to 17 in the US)

        https://www.youtube.com/watch?v=RfHTcloRdIU 97 year old running a restaurant (humans in true form)

        "world," as a source of new perceptions
        more https://substack.com/@cs3001

        "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

        LukeL 1 Reply Last reply Reply Quote 0
        • LukeL
          Luke @cs3000
          last edited by

          @cs3000
          Thank you. Here is the thread if other people are interested: https://bioenergetic.forum/topic/1799/ergothioneine-amino-acid-for-life-extension/14?_=1736257389403

          War is when a government tells the people who is the enemy. Revolution is when the people work it out for themselves.

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          • serotoninskepticS
            serotoninskeptic @Luke
            last edited by serotoninskeptic

            @Luke

            Using the macro visualizer by @exfatloss you can see that 1950’s Japan and Okinawa diets consisted of shockingly high carb intake (80-85% of calories) Coming from mostly white rice and sweet potatoes. This means they ate a very low-fat (low pufa) and lowish protein diet particularly methionine/cysteine/tryptophan. This could contribute to their longevity and leanness.

            https://macros.exfatloss.com/swamp?diet=eskimos_1914

            MauritioM 1 Reply Last reply Reply Quote 0
            • MauritioM
              Mauritio @serotoninskeptic
              last edited by Mauritio

              @Serotoninskeptic
              Wow, that is so interesting!

              Looking at the macros, they ate a very, very good diet.

              In the methionine thread I've written about high carb, low protein, low fat probably being the ideal diet (but restriction 2 macros is hard) and that is pretty much what the Okinawans ate !
              That also gives credit to the low protein idea being sustainable long term. Around 10% protein is what they use in a lot of studies, so that seems to be a good goal.

              "Key nutritional biomarkers for longevity among Okinawans include lower levels of homocysteine and higher levels of antioxidant vitamins, ..."
              https://en.m.wikipedia.org/wiki/Okinawa_Centenarian_Study
              --> both could result from a low protein diet

              Iirc they also have/ had higher androgens and androgenic Features than other Japanese ethnicities.

              This study shows Okinawan men have higher testosterone but also higher estrogen than American men.
              https://pmc.ncbi.nlm.nih.gov/articles/PMC8496353/

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              cs3000C 1 Reply Last reply Reply Quote 0
              • KvirionK
                Kvirion @LucH
                last edited by Kvirion

                @LucH

                Blue zones are just a BS myth...
                https://youtu.be/rB4lhT71SLo
                +
                https://www.dailymail.co.uk/wellness-us/article-13023311/blue-zones-healthy-life-bogus-fake-birth-certificates.html

                A little learning is a dangerous thing ;
                Drink deep, or taste not the Pierian spring :
                There shallow draughts intoxicate the brain,
                And drinking largely sobers us again.
                ~Alexander Pope, An Essay on Criticism

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                • cs3000C
                  cs3000 @Mauritio
                  last edited by cs3000

                  @Mauritio @Serotoninskeptic nice insight ty

                  Japanese and Okinawans were similar for averages (Okinawans had less disease too though) doi: 10.1196/annals.1396.037
                  (average, maximum) for Okinawans (83.8 years, 104.9 years) compared to other Japanese (82.3 years, 101.1 years),
                  e6cef64a-caea-4b18-82b6-cb804fa6211f-image.png

                  nearly 1/2 the pufa intake , relatively high for fat % but they also ate 16mg vit E which helps counter pufa vs 6mg with the other japanese (less vit E with more pufa). 9% protein & 13%.
                  72a74a72-fabe-4bb7-99fe-37220cfa9e30-image.png
                  check this https://journals.physiology.org/doi/full/10.1152/ajpregu.00834.2004
                  612c3fb1-df48-4f11-911a-650652fa9839-image.png
                  (^ I wonder if there's some exponential element to vit E need for higher pufa intake? other studies havent replicated that with lower, and their diets typically high in pufa. but rats are usually fed high vit E as a baseline already.
                  extreme dose not needed to counter a lot of the pufa, especially with lower intakes seen here. both also ate >200mg vit C too i think which helps vit E function, if the other japanese ate 16mg too would it have closed the disease gap a lot? which was still much better than usa)

                  Around 10% protein is what they use in a lot of studies, so that seems to be a good goal.

                  this was a good one, with 10% fat and ~80% carb diet (13% as sugar), (7% protein vs 13% vs 7% + bcaa,
                  they added 1.8g l-cystine to 70g casein (casein doesnt have much as only protein source, some cystine needed e.g for the sulfur reactions)

                  (mrna expression, in liver)
                  b1656081-4072-4d19-bff2-168243655d75-image.png
                  https://pmc.ncbi.nlm.nih.gov/articles/PMC6073443/#sec5-nutrients-10-00918
                  so 10% protein in the middle would still give a fgf21 ucp1 boost

                  their lean mass & bone gain suffered on 7% but some gain
                  yeah bumping up to 10% might be best of both
                  02ac8e24-fdc3-41a5-a636-730d9d26ea73-image.png

                  95a963ff-4e26-4a10-9c30-3d94514d76de-image.png

                  "world," as a source of new perceptions
                  more https://substack.com/@cs3001

                  "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

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                  • LukeL
                    Luke
                    last edited by

                    @Mauritio @Serotoninskeptic @cs3000

                    When Lindeberg examined the Kitava diet, he noticed they had a similar macronutrient ratio: ~ 70% carbs, 20% fat, 10% protein. Some fish and coconut, but mostly starchy tubers and fruit.

                    Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.

                    War is when a government tells the people who is the enemy. Revolution is when the people work it out for themselves.

                    serotoninskepticS 1 Reply Last reply Reply Quote 0
                    • serotoninskepticS
                      serotoninskeptic @Luke
                      last edited by

                      Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.

                      Could it have been the Tukisenta?

                      "The diet of the Tukisenta in New Guinea was studied in 1973. Their diet consists almost entirely of sweet potatoes. The Tukisenta were lean, healthy, and had little to no sign of heart disease or other diseases of civilization"

                      LukeL 1 Reply Last reply Reply Quote 0
                      • LukeL
                        Luke @serotoninskeptic
                        last edited by Luke

                        @Serotoninskeptic said in Reasons for longevity in Japan?:

                        Do any of you remember the people Dr. Peat sometimes mentioned in interviews who ate almost nothing but potatoes/sweet potatoes all year, plus pork one week a year? He mentioned they had good muscle mass despite low protein, but I forgot whom he was talking about and I lost my notes.

                        Could it have been the Tukisenta?

                        "The diet of the Tukisenta in New Guinea was studied in 1973. Their diet consists almost entirely of sweet potatoes. The Tukisenta were lean, healthy, and had little to no sign of heart disease or other diseases of civilization"

                        Could be. I found the interview (part 1, it starts at 16:25): https://oneradionetwork.com/dr-ray-peat-ph-d-answering-a-plethora-of-questions-regarding-health-diet-and-nutrition-january-1-2014/

                        Altough I didn't understand what he was saying. Something with ...inions?

                        Edit:
                        Here is another one, starting at 01:13:00. That was the interview I remembered: https://oneradionetwork.com/dr-ray-peat-ph-d-got-milk-milk-is-a-good-food-really-july-18-2019/

                        Pacific islanders, so could be Tukisenta.

                        War is when a government tells the people who is the enemy. Revolution is when the people work it out for themselves.

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                        • DavidPSD
                          DavidPS
                          last edited by

                          I am wondering if a large part of their longevity is related to the rich soil shown in the Connie Chung videos above and natural water shown in the video linked by cs3000.

                          Bruce Ames has a triage theory of aging.

                          Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage
                          (2006)

                          Abstract
                          Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.

                          “Medical science has made such tremendous progress that there is hardly a healthy human left.”
                          Aldous Huxley 👀
                          ☂️

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                          • serotoninskepticS
                            serotoninskeptic @DavidPS
                            last edited by

                            @DavidPS I noticed also in a few of the so-called "blue zones" they are drinking mineral-rich spring water that's been filtered through limestone rock, resulting in high mineral content, particularly calcium and magnesium, due to the limestone's composition. Specifically Nicoya, Costa Rica which has a high concentration of this mineral-rich limestone. Their traditional diet is also low-protein and consists of primarily peaty foods. Nixtamalized corn, black beans, yams, white rice, tropical fruits. The black beans are notably low in pufa compared to other legumes as well.

                            Soybeans: 5.1g/100g
                            Chickpeas: 2.7g/100g
                            Kidney Beans: 0.3g/100g
                            Pinto Beans: 0.2g/100g
                            Black Beans: 0.1g/100g

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                            • DavidPSD
                              DavidPS
                              last edited by

                              Here is a link to a photo of Connie Chung (born 1946) and her husband Maury Povich (born 1939). The photo was taken in 2023. From the photo, do you think that she is using the fountain of youth molecule that she shilled?

                              https://www.justjared.com/photo-gallery/4995792/maury-povich-connie-chung-rare-appearance-daytime-emmys-01/

                              “Medical science has made such tremendous progress that there is hardly a healthy human left.”
                              Aldous Huxley 👀
                              ☂️

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