Posts made by CrumblingCookie

@Pooooop
Could be also in part due to very contracted, dysbalanced muscles around your spine, specifically in the area of your shoulder blades and your lower cervical vertebrae. So the stiffness prevents the rotary motion and compresses otherwise pre-weakened nerve bundles to your hands, epecially when under further exercise load. Maybe your neck posture is way worse since the restart in the worse gym or you're training the wrong muscles instead of their necessary counterparts.

@DavidPS
I've ordered the BioGaia Gastrus tablets with the two L. reuteri strains to try it out.
It stands and falls with the lactose and dairy protein tolerability of the fermentation product.

@yerrag said:
Thanks for your literary weekend intro!

She encourages it's use against candidiasis, and no doubt has antifungal properties. I don't have candidiasis but I went to have my blood examined using live blood analysis and discovered my red blood cells to harbor fungal species much like candida that would act like a parasite as it's life cycle revolves

I don't have diagnosable candida either but the essential point I take from your report is the importance of whatever shapeshifting pathogens reside intracellularly in their respective tissue niche.
So I may very well have bred highly resilient cell-wall-deficient bacterial / fungal organisms in my gut cells from the antibiotics.
That turpentine
@CrumblingCookie said:

helps to maintain villous lenghts during a couple of days of starvation/fasting (I hadn't known that villous atrophy sets in so quickly from a "use it or lose it" point).

may very well also have an unexpected background then: That such organisms, when their intestinal environment becomes too inhospitable by lack of nutrients in fasting or by antibiotic treatment, penetrate and damage the intestinal villi.
As it's known and proven for hyphae, i.e. the protruding fungal forms of yeasts.

I had read Dr. Jennifer Daniels' short book on turpentine before.
And a couple of years ago I had already taken turpentine at 2 teaspoons per day for over two weeks. Which was a lot. I found 1 teaspoon already quite aggressive on the GI system. But I liked the "brain effects" of improved microcirculation (some headaches, though, too).

I'll continue the monoterpenes in the small amounts of 4 drops multiple times daily. Doing the maths, that comes to about 1.5 teaspoons a week in total which surprisingly matches the total of Dr. Jen Daniels dosing recommendation of a 3/4 teaspoon once or twice a week.

@DavidPS

Thanks for this hint. I've just watched the video/instructions by Dr. William Davis. I like him. 36hrs fermentation for 12 doublings of c. 3-4hours as the sweet-spot plateau of live bacteria; 300 billion L. reuteri per serving!

Previously I had only made my own "yoghurt" (by legal definitions it's not) with selected L-lactid acid producing lactobacilli or with bifidobacteria only.
I've noticed that using bifidobacteria can make dairy (proteins) completely tolerable. Including B. breve is crucial for that.
It needs at least 12-18hrs of fermentation, however, and with many brands/origins of milk it just doesn't work properly at all* (it either remains very liquid, doesn't truly ferment as it should, or as in one brand even starts bubbling wildly with a terrible stink because of prior contamination). Which left me dissatisfied. Along with the fact, that I don't actually want to mass-feed bifidos into my small intestine. So pasteurising the bifidobacteria-"yogurth" after its fermentation should have been the logical next step to gain maximum tolerability from dairy. With such efforts only to tolerate and utilize dairy, I simply chose to forego it and depend on other foods.
Nevertheless, it was a great thing to find out.
Using only the good lactobacilli (rhamnosus, casei, paracasei, salivarius. There was no reuteri, though) yielded a better and tastier "yoghurt" (or super-tasty cottage cheese!), but there was still incomplete tolerability.
A combination of selected lactobacilli with the selected bifidos gave the best taste in some milks in which the use of only bifidos would lack the "punch" of freshness from lactic acid – the acetic acid from bifidos has a stale taste in comparison.

I'll give the max-feeding with L.reuteri a chance. I knew about and used it before but merely as the mentioned small probiotic drops for infants which didn't do much at all. It sounds like a good continuation of my previous dairy experimentations.
*: Comforting to read that Dr. Eric Berg also struggles quite a bit to get his L.reuteri fermentation recipes and ingredients just right.

With bactericidal reutericin as its major metabolite this is another approach to circle in on taking out the nasty resilient hidden unknown varieties of pathogens in the guts. There's a common goal and effect there shared with the mentioned turpentine.
If those L.reuteri reports about shifting body composition, i.e. increases of youthful muscle and loss of abdominal fat become true that'd be fine with me.
Have you noticed anything of that?
Did you include or forego the also-mentioned L.gasseri and Bacillus subtilis?

Recipe as per Dr. Eric Berg: 1 capsule (20 billion CFU), 2 table spoons inuline, a little half&half milk/cream to blend everything into a paste, then a liter of half&half, ferment at 99° F / 37° C for 36 hours and then eat half a cup a day.

@yerrag said:

Use of natural substances available in nature that are known for their antifungal properties may help as a start. Taking turpentine orally, for example. This would help change the microbiome towards a dominance by bacteria instead of fungal forms.

When you said turpentine, did you only think of its antifungal properties or of more?

I've been harboring some aversion to turpentine and didn't try it as intended. A few days ago, however, I started 4-5 times daily 4-5 drops of aforementioned monoterpenes (from peppermint oil) and whilst it's ached a little inititally and especially when taken without any dextrose (it's recommened to be taken with sugar, just as turpentine) its effects are remarkably beneficial and remarkably quickly so.
I've tried to find associations of turpentines/terpenes with intestinal mucosa.

And couldn't find much, really. From a bit of crossreading, however, it appears to be the case that turpentine AT LOW DOSES, but not at large doses (opposite effects!), exhibits trophic effects on the intestinal mucosa and villous length and proliferation by releasing cytokines (and perhaps improved microcirculation).
It helps to maintain villous lenghts during a couple of days of starvation/fasting (I hadn't known that villous atrophy sets in so quickly from a "use it or lose it" point).

So overall, low but not high doses of turpentine seems to stimulate the intestinal mucosa, and sort of imitate a well-functioning microbiome--brush border interaction in the absence of a proper microbiome?
Or maybe it reinstates the proper microbiome by putting right the brush border functionings? It's difficult so say with these reciprocities.

@war4512 Good replies!

@zaaku said in How did you treat your NAFLD and how long did it take?:

[Consider three to four times as much daily choline.]
Is this recommendation from personal experimentation or from a study?

Own experimentations after having read the available studies. The RDIs and AIs for choline are lamentable.

@CrumblingCookie said in B12:

Without choline, supplementation of B vitamins eventually leads to liver damage (Biskind).

https://pubmed.ncbi.nlm.nih.gov/16273261/
Benjamin Y Lee, Krishna Yanamandra, Joseph A Bocchini Jr
Department of Pediatrics, Louisiana State University Health Sciences Center

Abstract

Based solely on clinical clues from a malnourished population, thiamin alone was intentionally and successfully injected to human cases with some tumors or masses. Two cases of submandibular gland cyst and 13 out of 15 cases of Baker's cyst were cured without recurrence for several decades. In a case with pathology-confirmed osteosarcoma, subcutaneous perfusion of thiamin HCl 300 once only reduced its circumference from 30 to 20 cm, equivalent to a reduction of 50-75% in volume, within 2 days.
Current concepts on the role of thiamin in carcinogenesis are controversial. Some authors claimed that thiamin supported high rate of tumor cell survival, proliferation and chemotherapy resistance and suggested anti-thiamin therapy for cancer. On the other hand, some investigators have reported evidence of prevention of several varieties of cancers by dietary thiamin. A limited number of animal studies revealed evident relationship between thiamin deficiency and cancer development. Therefore, further study on the mechanism switching thiamin between cancer supporter and suppressor is needed.

@zaaku said in How did you treat your NAFLD and how long did it take?:

I was consuming 500mg choline via eggs and milk, but added an extra egg 2 days ago to reach 700mg choline per day.

Consider three to four times as much daily choline.

Consider TUDCA and monoterpenes and CoQ10.
Consider a cholagogic of your choice like sylibine, chlorogenic acid (coffee), coffeine, emodine, artichoke leaf extract, gold coin grass, liquorice.

@zaaku said in How did you treat your NAFLD and how long did it take?:

increased my T3 dose to 20-25mcg almost 3 weeks ago which has led to a decrease in appetite.

Consider the possibly detrimental and exacerbarting impact of additional T3 on an already burdened liver.

@LucH @Jakeandpace
That graph, whilst displaying B12+Folate+P5P as the most crucial, does not show B4.
B4 is choline. It's really unfortunate that B4 has been dropped from the "canonical" B vitamins.
In my view all good vitamin b complexes should build up on no less than 150-200mg of choline per dose.
Without choline, supplementation of B vitamins eventually leads to liver damage (Biskind).
It's also super important for the nerves and brain and all organelles as phospatidylcholine in the membranes. Which is a vital building block when stimulating cellular replication with B12 etc.
Choline can be converted to TMG=betaine for methylation purposes. But that's a one-way-pathway, i.e. supplying betaine (or methyl-B12) only spares some choline going into that route. Which is of limited use and perhaps even conflictive if increased methylation results in a metabolic boost (cave: or unfavorable epigenetic silencing) with which overall choline intakes are too low to keep up.

@Serotoninskeptic said:

He also gets jitters and anxiety from coffee which leads me to believe its a nutrient deficiency or thyroid issue. Any advice is appreciated.

He also reported getting cold extremities after drinking the coffee. This leads me to believe cortisol and/or adrenaline are chronically elevated.

Glucose loading cures everything?

@Jakeandpace

Don't neglect the P5P and perhaps give choline a try. Either citicoline or the common bitartrate three times a day?

@Peatful said:

It’s “suffocation” in many places where it is legal

Supposed to go fast
Supposed to…
And yet many have needlessly suffered
While family watched
Some wanting to reverse their decision

I feared it to be something along the line of ineffective executions of death penalty.

@Insomniac said:

This narrative is very useful for framing support for widespread euthanasia as loving and compassionate.

I agree with you there. It remains ambiguous.

@Peatful said:

Read the data on how it is done
What it looks like
The cost

Brutal and or cruel…

I haven't looked into that tbh. Is it just "cold" or brutal in many more ways?
If it were me I certainly wouldn't want to have it in a specified medical setting. I had seen lots of possible ways in the early days of internet and would want to choose my own way and moment.

@Peatful said:

I will leave it to you as to why one should care

It's sinister and my thoughts about it are ambiguous.

@Peatful said:

Rebranded eugenics

In the bigger picture I am very certain that we are not amidst any eugenics programme.
It's kakogenics. Or metriogenics to the lower end of such. You all know the playbooks.

In this sense and the commercial setup of the world MAID is like the ultimate discarding after having caused great demise upon a human being and leeched off all its commercial securities.

That said, to those who find themselves at the irreversible end of such willful malice,
or to those who find themselves at the end of otherwise greatly unfortunate fates...

I find this a classic example of misinterpretation of scientific studies.
And there are way too many to discuss each one of those in their wrong conclusions.

D3 metabolism in rodents is known to be crucially different from D3 metabolism in humans.
It's beyond poor science to even directly convert these rodent findings to human equivalent doses.

This just feels like science-spam.
The findings themselves and the priorly known implications of hypothyroidism may be valid.
The conclusions (and motives for funding such studies) with regard to "vitamin D prevents it" are not.

@Sam-Crow said in Methionine restriction shrinks tumors by ~90%.:

They used the exact same 'complete' tumor for comparison in pictures 2 & 3 but another one in picture 1. Why is that?

No, watch closely: They've used the very same complete tumor in all three pictures. But in the first picture it is turned by +90° clockwise and it looks fresher. So they probably did the methionine restriction first along with the control, then froze the control while they did the other two tests and took the complete control tumor back out for the later comparison photoshots.

@Mauritio said:

we need small and hydrophilic molecules for an anti-fungal effect

Im looking for anti-fungal candidates that fit the above category:

Encapsulated calciumhypochlorite granules ("Chloryte") may fit this bill for the upper GI and various deep tissues. It's rather rough and destructive and not a thing to do for more than two weeks at the very most, IMO.

@Mauritio said:

I took Haarlem oil daily for a while.
I believe it contains turpentine and sulfur. I got less and less of an effect as time went on so I stopped. But I recently reintroduced it and found that cycling it, seems to maintain its effects.

Turpentine (or more generally monoterpenes) reduce hepatic cholesterol synthesis, thereby reducing the cholesterol-saturation of bile which is then able to gradually dissolve cholesterol "plaque" or even proper stones along the bile ducts and in the gall bladder. That improves the biliary milieu along with better biliary flow. It's a very long-term process, however. It takes several months of taking monoterpenes ("Rawachol" capsules or tincture is an OTC product) 2-3 times daily. Tudca or Udca works well together with monoterpenes.

@Mauritio said:

I'm not sure how the treatment should look.
Increasing transit speed and frequently emptying the gallbladder by eating fiber, using specific supplements like FXR-agonists

Tudca and Udca also reduce the same enzyme of hepatic cholesterol synthesis, while additionally altering the bile acids composition towards being much more hydrophilic and less sticky, and also increasing the bile salt export pump for an in overall much greater bile flow (less stasis).
I'd rather use those daily instead of doing any more gall bladder flushes ever again (which only work in a very mechanical and macroscopic way).

@yerrag
Sorry to read that you crashed into excessive MB MAO-inhibition and agitation, anxiety.
3x32mg = 96mg of MB in one day after already 48mg the day before and some the day before is really much.
It'd be easiest if some of the caused anxiety and insomnia were caused by low-BG and some dextrose could help.
I know fresh ginger, ginger juice or oily ginger extract are anti-serotonine at high doses. They'll block CYP3A4, though, so not a sustainable thing to do.

Not sure whether your CO hypothesis holds up after a trial with this much MB. Do you think your current extrapolations are becoming too far stretched? Perhaps very limited in their practical extent, even if theoretically true?

@yerrag said:

After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.

The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. If the 20mg didn't bring any benefits but no bad feelings either, I myself would take try another 20mg already one hour after the first dose.
If up to 1mg/kg bodyweight within a couple of hours brings no relief I'd dimiss it and look elsewhere and keep MB in the cupboard for an acute urgent situation of ischemia.
I think MB is a very powerful and important instrument acutely.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). I won't take it again without carbs or glucose / on an empty stomach because of the glucose drop.

I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.

@yerrag said:

I don't have a hydrogen machine, though I admit I also am skeptical of hydrogen machines.

That's okay. Maybe careful inhalation of H202 solution (stabilizer-free) could also help the impaired alveoli? Either with a spray bottle or nebulizer or a vaporizer, humidifier for the whole room over night at about max. 1%.

@yerrag said:

As how would more oxygen work when the lung is watery and can't take in oxygen in normal amounts.

Have you looked into uses of molecular hydrogen gas?
Especially within recent years it has shown to be very effective in pulmonary conditions. By reducing the inflammation at the alveoli level the actual gas exchange is re-enabled. I.e., giving O2 in increasing gradients in pulmonary conditions often only increases the stress and doesn't get through to the bloodstream whilst there's more and more water filling the lungs.
The molecular hydrogen however (added to normal air, or as H2+O2, or as Brown's gas from a wet cell catalyst comprising H2+O2+plasma H2) soothes and allows for O2 to get in and CO and whatnot to get out.
I can confirm it increases SpO2 and capillary perfusion within moments. It's also a sort of a nutrient feeding right into these ATP nanomotors (ATP synthase?). And it's somewhat immunoinhibitive to an uncertain practical extent, decreasing NETs and citrullination and by antagonising TLR4 also the beta defensins/innate immunity and of course the ROS by neutralizing the hydroxyl radical (HO) in particular.
Overall the best effects of molecular hydrogen arise not from continuous but from intermittent use.

Lymphatic massage manuals or one of those "Chi machines" may be another idea to support lymphatic drainage, along with foot or full body baths with perhaps sodium hydrogen carbonate or hydrogen peroxide (to bring in more oxygen to bind with the CO (which also creates HO radicals so in a way it's an opposite approach to H2)) or magnesium chloride (the chloride for increasing renal excretions).