Posts made by CrumblingCookie

@psi
Here's a thought which may cover energy metabolism, acidity/sensitivity and intestinal microbiome balance:
According to the FDA it's fine to add up to 0.05% of H202 to milk for cheese production.
That's about 4 tablespoons of 3% H202 to a gallon of milk.
What if you drank SUCH milk?

@S-Holmes said:

I so wish I could take hydrogen peroxide. I have 3 bottles of 35% food grade in my fridge, but taking it orally just nauseates me terribly, so using it topically (diluted of course).

I'm wondering whether this is because you are so full of toxins (for some odd reasons there is said to be no Herxheimer from H202) or because it yielded such a metabolic boost in you that it sank your glucose when you had tried it in the past? How's 1 drop 35% but regularly?

@S-Holmes said:

Thanks for the good discussion friends. This fellow lab rat appreciates you!

+1 and thank you too!

@gentlepotato said:

Stephen's explanation is the amount of glucose limiting events, but (without going in to my family histories and ancestry in to great of a detail) I have generations of severe glucose limitation in my genes

I would like to mark this as a side quest and contribute that immune cells are the continually most energy craving type besides nerve cells. Nevertheless it would ultimately affect all kinds of tissues and cells to have significant shortcomings in cellular energy usage over the long term. [In any kind of starvation or fasting, immunity drops very quickly (which can be palliative and life-saving by limiting the rate of immunological damage in the short term)].
So what you mentioned about (epi) -genetic effects, potentially trans-generationally, and the very real occurrences of trans-generational trauma by physical abuse, war crimes, starvations and the like may very well be perpetuated not only by the original glucose-limiting shunts but as well by the opportunistic changes of the intrinsic intracellular pathogen load, i.e. the so-called metagenome, which is being passed-down from parents to child and can be much exacerbated by adverse events "Metagenomics Of The Human Body", findings from the Human Genome Project.

@S-Holmes and @gentlepotato
I have not read up on itaconate yet because I'm having too much on my plate rn. So I need to leave this puzzling-together to you for now and am looking forward to your further findings.

What I have tried and can report back on:

Taurine: I had taken 700mgs of taurine to every dextrose serving. It made me more tired/sleepy/groggy like previously when I had increased dextrose. Also, I was craving more dextrose and instead of 80-90gs I was using 90-100gs at a time. So I got the confirmatory impression that taurine definitely enhances glucose uptake.

Hydrogen Peroxide: This can be good news to everyone and particularly to those who've been gaining weight with dextrose. Drinking 2ml of 3% H202 (equivalent to about 3 drops of 35% H202) in half a glass of pure water several times a day increased my warmth, made me a little less hungry, made me crave less dextrose (back down to pretty much 80gs at a time) and looks like it's very subtly but steadily reducing my weight. It provides more oxygen to everywhere, but the H202 itself also acts immunostimulatively, tissue pH balancing, peroxidising many toxins and hydrocarbons and it's actually a cofactor in many enzymatic pathways. E.g. the peroxisomes in almost all cells use and produce H202 and they are where fatty acid oxidation for non-glucose energy creation takes place.
I'm greatly interested in how supplemental H202 works for others who do the glucose protocol.
It may fit in well and make for a holistic approach as an integral complement to glucose. And it's just as stupendously basic and essential which makes me like it a lot.
I highly recommend everyone to read the book "The Truth about Hydrogen Peroxide".
The guy who wrote it has put a lot of effort into it with hopes and aspirations no lesser than those of Dr. Stephens.

@CrumblingCookie said in Glucose loading cures everything?:

The organic dextrose comes in large, white, PP plastic containers and at the first (and every ensuing) opening of that container I was taken aback by a distinct plasticky smell. Luckily, however, no matter how hard I try I cannot sense that plasticky smell from the dextrose powder once I've taken it out of that container. So that's good.
Taste-wise, this particular organic dextrose seemed even "softer" than regular dextrose but I'm not very sure about this and whether that's a good (extra pure?) or a bad (solvents?) sign.
I will work/drink my way through it and report back.

Update on the dextrose powder quality:

I'm coming close to having 20kgs of dextrose consumed.

A few days ago I had used up the organic dextrose (large PP container) and so changed back to the dextrose bought at the supermarket (in small cardboard boxes, baking section).
The latter immediately tasted revolting to me. Urgh. I taste a hint of soapiness in it, too. Certainly a bit more nausea from it. And again it felt much harsher against my teeth (sucrose residues?) than the other powder.

I immediately ordered the big container again. In the meantime, I've neverthelesse been using the supermarket dextrose and I somewhat re-accustomed myself with it but it remains unpleasant.

I suppose the key take-away from this is to source and try different dextrose powders. Organic may be preferable to conventional. And what comes in plastic containers may be preferable to what comes in cardboard.

@GlucoseOrBust
On the RPF I've found a link to this ebook and website and mentioning of "The One-Minute Cure, The Secret to Healing Virtually All Diseases" as a pdf floating on the internet.
Oral H202 seem to be a neutral-tasting, deeper and rougher precursor to the CDS.
You will find many more people taking CDS as per one of the many protocols. I myself simply can't stand the taste of CDS anymore.
There's also oral sodium chlorite, which is to be taken with a stomach acid buffer (potassium or sodium hydrogencarbonate) and named Chlorite In Soda Solution. That's also almost neutral-tasting and much longer lasting with once or twice a day being sufficient and reacting with acidic microenvironments in the body over many hours. Half a drop of 25% solution is enough to start with.

@S-Holmes
Here's an article on its dermatological use: https://doi.org/10.1016/j.jaad.2019.05.030. The 1-6% gel concentrations actually seem to more successful and more tolerable in treating acne than common other creams.

@S-Holmes said:

I tried food grade H202 in water a few times, and again recently. I can't do more than 3 drops without feeling sick.

Which percentage of H202 did you use 3 drops of and was it pure or with stabilizers?
Some nausea is always to be expected from oxidative therapies, unfortunately. The use of GI binders can help it go away until the dose can be increased.
But what if glucose will substantially help with such nausea, as it nourishes the essential liver functions AND prevents the BG from dropping which causes nausea?

I'm becoming really excited about what you guys can figure out and how this can also help me.
And perhaps even accelerate and complete the results for the 80% and enable the 20%. All of whom are good people, I hope. I only want the intrinsically good people to be finally helped. Not the nasty ones in their capacities. As the nasty ones demand stupendous gains even among themselves, I like to imagine that the odds are in my favor and word of mouth could spread like wildfire among the remains of humanity.

@GlucoseOrBust said:

For what it's worth, Stephens talks about glucose, oxygen, and water being the three critical factors of energy metabolism.

I think this is an oversimplification, as studying things like Buyteyko breathing shows that air hunger is a subjective experience based on an individuals tolerance to CO2 build up in the lungs and blood.

! Thanks. Wow. It fits together. Now I feel the need to read up on Buyteyko breathing.
I've heard military special forces apply very specific breathing techniques in high-stress situations which probably limit the glucose-inhibiting aftermaths. Is that the Buteyko?
It's very important that you mention the 15-20% of people who dropped out of the glucose protocol even with DS. They could very well all be nonresponders because of missing links.

@S-Holmes said:

OMG. Have you tried H202?

I am looking into that now and am open to try it orally.
Maybe as small volume H202 enemas every other day, too, instead of GlucoseOrBust's suppositories. I either need the H202 solution free of stabilisers or find out whether I can neutralise the common phosphoric acid stabilisers with calciumcarbonate.
The recommendations are to use distilled water and definitely no minerals, proteins or vitamins with H202 as they can become much stronger oxidants than the H202 itself. Glucose, however, appears to be fine to be concurrently combined with H202?
As far as I understand so far, the catalase in the stomach lining needs to gradually increase its activity and will convert pretty much all of H2O2 to oxygen? But even in IVs, the H202 is said to be converted to oxygen within a fraction to a couple of seconds.

@S-Holmes I've had one or two ozone IVs. I can't remember the ozone rate/device setting and session length, nor the details of how exactly I reacted but only that its effects for me were rather contrary to what the GP and nurse expected and that they were a little irritated and closedmouthed about it.
The ozone IV made me quite stressed and exhausted, physically. I had it stopped five minutes early and struggled to walk up a staircase afterwards and must have looked accordingly because a stranger stopped to ask if I'm alright and insisted to help me and eventually stood next to me awkwardly long until she was somewhat sure I won't be tumbling down.

I've done a few chlorine dioxide IVs at 120ppm in Ringer lactate solution. I think that's the maximal practical concentration. I also know that lactate's not ideal and anti-metabolic, but it retains ClO2 in solution. That felt really good and warming and clearing my head like a fresh breeze should do.
That was at least a year before my ozone IV experience, though. So I might have been not yet as deep in a hole when I tried the ClO2 IV as when I tried the ozone IV. But the oxidative potentials also differ with +2.03V for O3 and a much milder +1.57V for ClO2 [H2O2 is +1.76V, O2 (and therefore H2O2 after catalase enzyme interaction) is +1.2-1.4V].
IIRC I had tried 240ppm but stopped it already after a few minutes because of venous irritation.
I had also tried subcutaneous infusion, known as hypodermoclysis. That didn't pan out for me at all as it simply didn't disperse but caused a swelling of half a tennis ball until I stopped. I suspect the max. ppm for hypodermoclysis is even lower. Also, I'm no professional with only little experience on myself (one-handed, of course, in the case of IVs).
Dr. Harmut Fischer (Chemist in Germany) spoke of 120ppm ClO2 in Ringer's.
Dr. Noel Rodriguez (GP, theologist in Guatemala) spoke of 30ppm ClO2 IVs at 40 drops/min and even at that low end issued a warning to diabetics about ClO2 IV lowering BG by a lot and that the insuline dosing may need to be set to half or even only a third of the usual. That's quite a clue for the glucose context.

On a potential side quest with chlorine dioxide, sodium chlorite, hydrogen peroxide:

In the results of his 1986 review on "The Therapeutic Use of Intravenous Hydrogen Peroxide", a therapeutic concept which is said to be equal in effect to the use of hyperbaric oxygen chambers, Dr Charles Farr described an "all-or-none" switching to a metabolic rate at about twice the baseline level brought about by the increased oxygenation. I found this interesting, because an increase of the metabolic rate, although reliably sustained over the long-term, is, after all, what I'm after with the glucose protocol.
He wrote that this was independent of using a 5% dextrose solution along with it or not.

I believe the latter finding does not hold true over the medium or long term and certainly not for everyone. That doubling of the metabolic rate must be fed somehow.
Surely, a shift from anaerobic to more aerobic metabolism bears a huge energy potential in the amount of ATP produced from the same amount of substrate and this could be all it takes for some. But what when tissue and liver glycogen already are or become depleted?
I don't know about the raise in efficiency or level of beta-oxidation of fatty acids from oxidative therapy. I certainly know, however, that excessive or extended oxidative therapies become very exhaustive and are not crucially alleviated by the proposed repleting of antioxidants.
Hence, I am now thinking that a huge stumbling block in any oxidative therapy will be stress and catabolism by lack of energy.

Cue in the dextrose!
Given that OXPHOS needs glucose and oxygen as substrates, increasing both ought to complement each other reciprocally. More oxygenation may enhance the efficiency already of small serving sizes of dextrose. Or perhaps more oxygenation may ultimately also increase/accelerate the utilisation of greater amounts of dextrose.

Do you people think this to be a meaningless oversimplification?
Or is such oversimplification right spot-on since we are already engaging in the almost ludicrously simple needs for glucose and its significant results?

To me, the fact that @GlucoseOrBust was recommended by DS to try methylene blue twice a day (in absurdely high amounts, imo) seems to tap right into this context of providing more oxygenation deep down into the tissues along with providing the glucose.
However, I deem methylene blue to be a derivation too cumbersome and too alienated of the in overall more fundamental sources for circulatory and tissue oxygen.
Unless DS purposefully intended to put him into MAO-blocking for the misled goal of raising adrenaline, noradrenaline, serotonin. Which can be greatly helpful for some, but shifts to adrenergic hormone signalling and is kind of a shot in the foot, leg, guts and brain, metabolically.
@GlucoseOrBust Did he explain to you why MB other than by "He heard from someone he has trained that their clients were seeing benefits with combining MB with dextrose. It seems to show some glucose uptake benefits in some studies"?

@S-Holmes said:

Well selected homeopathic remedies (pure energy) WILL recharge our cells...until they can no longer be energized.

It is being said that CDS, sodium chlorite, peroxide is often a prerequisite for homeopathy to work (again). To a substantial part this ought to be due to a reduced overall pathogen burden. To another due to oxidation of toxins and waste. I am now thinking that, as oxygen donors, they must also benefit OXPHOS and thereby every cellular and organ function provided there's enough glucose substrate? ClO2 or peroxide may then complement the glucose loading?

I am thinking that a lot of the supplements and supposed remedies I had been taking over the years were all in wain. Especially, I am thinking many (the potentially most beneficial of them) exacerbated the glucose deficiency dilemma. Consequently, I am thinking that now that I am providing sufficient glucose, I may need to rewind and redo/retry all the "good" supplements because only now they become both able to be used and necessary as cofactors for every cellular and organ function.
I a way, this would mean back to square one and a reevaluation of all supplements and remedies I know since long ago and which I had previously used and discarded.

@Jaffe

I've received my order of 10kgs "organic" dextrose and am wondering whether that makes any difference to "regular" dextrose.

The organic dextrose comes in large, white, PP plastic containers and at the first (and every ensuing) opening of that container I was taken aback by a distinct plasticky smell. Luckily, however, no matter how hard I try I cannot sense that plasticky smell from the dextrose powder once I've taken it out of that container. So that's good.
Taste-wise, this particular organic dextrose seemed even "softer" than regular dextrose but I'm not very sure about this and whether that's a good (extra pure?) or a bad (solvents?) sign.
I will work/drink my way through it and report back.

Experience update:

6 weeks into dextrose now.

• In the meantime I had been taking 2grams of BCAAs (2:1:1) with every serving of dextrose for over a week, because of the thoughts from this thread on the amino acids / tryptophan shift. I will need to report back over there, too.
  Essentially, taking BCAAs did not work at all for me.
  Not only did it not improve my response to glucose, but it worsened it.
  I reckon that's due to both the BCAAs direct effects as well as due to that it lowered my appetite and thus significantly reduced my intake of proper food during that time.
  Eventually I added an additional >5grams of glycine everyday to the BCAAs, because intuitively I felt that my feeling weird and "off" was less from a glycine/BCAA combo.
  I think BCAA products should be grouped/blended with glycine as a standard.
  Anyways, they all constistently exarcerbated my intestinal upset, causing me mucuous and watery diarrhea in a sort intestinal colic. I gradually, measurably and visibly lost an excess almost 3kgs body weight (which I had suddenly put on back in April for reasons unknown).
  Also, I did sleep well anymore. That glucose-benefit on deep and coherent sleep was completely gone.
  Not at all what was expected and hoped for by correcting the presumed glucose-induced free tryptophan increase.

• Also, while having taken the BCAAs, my previous increase from 56grs to 100grs dextrose servings seemed to have been to harsh.
  I felt nausea all the time and the dextrose did not taste nice anymore but almost unbearably, undrinkably sweet.
  I had been wanting to reduce the dextrose for over a week, but pushed through - waiting for improvement. And also because I was too unwilling to measure a lower serving size and count stupidly many tablespoons. (I have lots of 2 oz. / 64ml scoops which were supplied with protein powders. Once such scoop measure 50grs of dextrose.)
  Eventually, I decreased to 80grs per serving. This was much more bearable.
  But its effect also did not last for the full time between servings anymore.
  On the plus side, this remembered me to properly eat all day.
  Especially so once I stopped the appetite-suppressing BCAAs-Glycine.

• With no BCAAs-Glycine and my food intake back up (beef, lamb, haricots verts), suddenly the glucose "kicked back in":
  I finally experienced that familiar physical weakness and calm tiredness for several days and got back better sleep again.
  My weight is back up, sadly. In part surely also due to not being reverse-puked-empty in the intestines.
  I hypothesize that it's very essential to keep eating properly while on dextrose.
  I hypothesize that this is one of the reasons for the recommendation of an only gradual increase of dextrose serving sizes - to not lower intake of proper foods but supply extra energy as needed with an ever-increasing (healing) baseline.

• I now also feel the need for more thiamin (B1) for the glucose. I will increase it to double-digits with every serving.

• I continue to have profound issues with fat digestion or bile uptake. Even the slightest amount of fat in my food is terrible for me and comes out as oily BMs.
  Cholestyramine did not work. I reckon it's either a mucosal (uptake) issue or maybe an amount or quality of bile issue.
  I don't know what to do about the former.
  For the latter (and instead of more glycine) I now take .7grs of taurine with every dextrose serving to increase my capacity for necessary bile acids conjugation (700mgs taurine is a level 1ml scoop).
  As many of you may know, taurine usually (and probably especially in use pre-damaged susceptible people) absolutely shatters glucose levels. With ample glucose I am pleased to find I can now tolerate taurine.

Summary:
Currently 5-6x daily: 80-100grs dextrose + 1.5grs potassium chloride + 10mgs thiamin with low other B-vitamins + 700mgs taurine.
Making sure to eat enough meat every day.

Perhaps the carnivore+dextrose type which DS briefly mentioned is particularly beneficial? Part of me expects wildly increased aging from advanced glycation end products. What relevance has weight and age appearance in the face of my daily misery, though.

@S-Holmes said

@lulueatsmeat You might want to hop over to the glucose loading thread. Since you've tried everything else, like most of us, it's worth a shot.

This one: https://bioenergetic.forum/topic/2319/glucose-loading-cures-everything/351

This. Join us self-determined guinea pigs :-).
You may want to have a look into the Marshall Protocol, too. Because acne as a constant skin infection you are not overcoming and also malfunctioning thyroid hormone metabolism fits that, too.
https://mpkb.org/home/mp

Without assessing the validity of your gut feeling (maybe you don't need exogenous fatty acids but more endogeneous synthesis with the help of B5 and B6 and B7?),
@gentlepotato said in Glucose loading cures everything?:

What fat source has the most nutrients per grams that would be supportive, in terms of neurotransmitters, brain health, Krebs cycle, mitochondria?

I'd confidently say cocoa butter (pellets) and beef or lamb tallow to this, as they contain lots of valuable long-chain saturated FAs and stearic acid (for mitogenesis) especially.
Or instead of tallow: Fatty cuts of beef or lamb and eat/keep/separate the fats after c. 3hrs of low-temp cooking.

I haven't yet read through that paper you posted and the itaconate ways.
Thanks @S-Holmes. Not sure which homeopathic remedy would be right for me right now. But I've added Glechoma tincture for my detox suppport (Lysimachia=Gold Coin Grass=Jin Qian Cao may be more available to some).

@gentlepotato said

If you think you have a “glucose limitation” look up the hormones produces in the hypothalamus, pituitary gland and adrenals, and you might find the explanation for your weird symptoms.

Do you mean to say that e.g. a suppressed circadian TRH curve or a stunted TSH response to exogenous TRH (i.e. a functionally atrophied pituitary gland) could be commonly associated with overall glucose limitation?
Reading your long post had me impressed as it means some of your brain was clearly working well enough to start and accomplish that.

@gentlepotato said

I am guessing that with hypoglycemia there’s often less ability to store glucose. I think maybe the liver (and body overall) will store fat instead, when it’s not able to store glycogen (or doesn't have any extra glucose to store?

Which is another reason I think taking big doses won’t be helpful: I don’t think the body is able to store the extra glucose well - yet. That will change with time I think, because if the liver is storing fat it will start to release it and store glucose instead.

Interesting. And maybe this relates to what I am going through described further below?

@S-Holmes said

I think supporting healing with "energy medicine" is advisable.

What measures do you mean by "energy medicine"?

@Jaffe on noticing any difference between dextrose products' quality:
I have not yet switched to the organic dextrose but will report when I notice any differences or when not.

Experience update:

4 weeks into dextrose now.
Last Tuesday/Wednesday I had made the large increase from 5x c. 56grs to 5x 100grs daily.
To my surprise this time I felt weak and drowsy for only one day, in contrast to my previous increases.
On the plus side I have not been feeling "snackish" anymore in between my dextrose servings. So the higher serving size for me currently lasts longer than the previously lower amount.
By Friday the anticipated digestive troubles began to set in again, starting with terribly oily and unformed BMs. I have eaten no fats and no oils within the past week. Seriously zero.
Throughout Saturday I had mucuous watery diarrhea. Followed by a some flatulence.
Since Sunday it's awfully oily BMs again.
I took activated charcoal and psyllium on Friday and on Sunday. I am thinking that I may need regular daily GI binders. I don't know if cholestyramine would help and have just drunk a 4grs package of that.
Also, on Friday evening I had started to add 2grs BCAAs to every dextrose serving because of the tryptophan shift brought up in the other thread here.
Clearly, adding BCAAs did not alleviate the digestive issues as hypothesized but probably even enhanced the GI issues from upping dextrose in me enormously.
And I can't say whether this is ought to be a categorically "good" thing to my body's benefit.
Practically and right now there's definitely something very off.

I appreciate all helpful suggestions on these reactions and how to manage them.

I've received my order of 10kgs "organic" dextrose and am wondering whether that makes any difference to "regular" dextrose.

I.e. how big of a glyphosate burden there could at all be in "regular" dextrose after it's enzymatic processing and filtration, i.e. its "processing factor" which is hopefully <1.
Since dextrose powder is practically protein-free, there also shouldn't be much glyphosate (glycine-like) residues?
Does anyone have an inkling?

Seeing that dextrose is being consumed as an isolated substance, devoid of any protein and especially glycine natural to all foods I am thinking that any residual impurities could in theory have a much bigger negative impact.
Maybe that's significant. Maybe it's not. I couldn't find any analytics.

Here's my preliminary collection of various bits of info:

• The official MRL (Maximum Residue Level) of glyphosate

• for sugar is 25ppm (US), !!!

• for sugar beets is 15ppm (EU), !!!

• However, since dextrose is derived from starch and therefore either cereals or corn:

• for cereals it's 30ppm (US, EU), !!!!

• for corn it's 13ppm (US) !! or 4ppm (EU).

• It therefore seems dextrose derived from corn would be generally preferable.

• The ADI (Allowed Daily Intake) for glyphosate is 1.75 milligrams per kilogram of bodyweight per day (mg/kg/bw/day) in the USA while the European Union has set it at 0.3. (0.5?),

• This 0.3mg/kg/bw/day means an officially allowed maximum of 21mg glyphosate per day for somebody weighing 70kgs. This could be 700grs of dextrose.

• We all know those MRLs are set way too benevolent. Probably by some orders of magnitudes.

• Officially, dextrose from cereals could contain up to 30mgs of glyphosate per 1kg?
  However, in the few origin declarations which I've seen the dextrose actually comes from China and only gets repackaged domestically.
  I couldn't find MRLs on finished dextrose, neither for the USA nor the EU.

@haidut
I had also read your previous post on that 300mg-biotin-per-day study and can attest by my own experience that there really are things opening up at thrice daily doses of about 100mg B7.
Practically, however, I ran into a few issues. What are your opinions on these?

Biotin:

1. I don't understand how study participants could cope for so long with such high doses, since B7 competes with B5 for uptake? Especially with regard to restoration of myelin sheaths, cell membranes and endogenous fatty acid synthesis they are both interdependent. I kept running into deficiency of one or the other and had to alternate both at least once every few days.
2. I felt that at such high doses, purity and fillers really become a significant issue. I've tried different brands because of this and they ranged from awful (with excessively much MCC) to something-is-still-off. Pharmaceutical quality in general is only >97.5% purity which by itself I consistently find totally inadequate in many cases.
3. Perhaps related to 2). My GI system and BMs became unbearably upset by high biotin doses. I suspect biotin exhibits inhibiting effects on aminooxidases similar to thiamin (thiamin metabolites) through displacement of enzymatic flavoproteins? I'm convinced much of the beneficial effects in Antonio Costantini's high-dose-thiamin therapy stems from MAO inhibition in the ganglions.

Riboflavin:

1. Are such high bolus doses really sensible in people who are unaffected by that recognized genetic riboflavin transporter defect?
   .1) I have noticed much better effects and tolerability from single digit mg doses continually (3-4x) throughout the day instead of higher doses twice or once daily.
   .2) Someone on the forums reported to have had his actual serum/blood FAD and FMN levels tested with different amounts of B2 and that their ratio and the absolute value of FAD totally plumetted from high doses of B2, whereas FAD and also his symptoms improved with low doses.

Side note: I have used B2 in amounts up to 2grs for clostridioides prophylaxis because of the studies on its redox effects and the aerobic-anaerobic gradient of the intestinal lining and its microbes. While such amounts are probably really not harmful, they made for purging and very awful BMs.

Hope you are doing well! And thanks for all the work!

@LetTheRedeemed said

It would be a moot point as the glucose itself is found to push tryptophan in the bloodstream. In fact I was reminded of my issues, as people were describing problems on the protocol of glucose, so I think I may have found the problem.

It also gave me diarrhea. I’d be interested to know if people are getting digestive problems on the protocol… of course they may call it a herx reaction or detox

Yes. I have been getting rough digestive issues for a couple of days after every increase in dextrose and have written on this in the other thread.

I've only just read Limon9's 2022 post and the table in
Yokogoshi H, Wurtman RJ. Meal composition and plasma amino acid ratios: effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism. 1986 Sep;35(9):837-42.
Dextrose really more than doubled rat plasma tryptophan. And especially Leucine really tanked to about half. When there was no dietary protein.

There are two valuable approaches here I see opening up:

1. Take gelatine or BCAAs together with each dextrose serving or pay heed to being "loaded-up" all day with sufficient dietary protein in digestion.
2. Yerrag's mentioning of lowering the insuline-spike from carbohydrates/sucrose/dextrose by facilitating cellular uptake and metabolic usage of glucose.
   This can underscore the importance of:
   ...2.1) Gradual increasing of dextrose servings in accordance to the increase of metabolic glucose usability.
   ...2.2) Cofactors for cellular glucose uptake and sparing of insuline. E.g. potassium and chloride.

I'm already doing 2.2) but haven't been able to eat my usual amounts of meat recently.
I will try a 1000mg capsule BCAAs with every serving.
Oddly, however, and despite preexisting serotonin issues of mine, when I had tried these BCAAs capsules before they had made my GI system much worse instead of better.
Are BCAAs and glucose perhaps significantly reciprocal in their requirement?
I know that gelatine/collagen/glycine and also AAs like taurine lower blood glucose and can effect stress reactions, which stands in stark contrast to what they ought to bring about.

PS:
a) How much BCAA or gelatine do you reckon are necessary to compensate the AA-shift by every xx grams of dextrose (if there were no other dietary protein)?
b) Perhaps I'm being too dumb atm to see the mechanism behind these extracellular amino-acid shifts. Do they happen because the non-tryptophan amino acids are being "put to good use" by insuline and/or carbohydrates?

@LetTheRedeemed

I did a deep dive in to why I was getting headaches from too much sugary foods away from meals

Would you try pure dextrose sugary foods as a crosscheck to your experiences with sugary sucrose (50% fructose) foods?

(USA Smarties, maybe marshmallows if you can find good ones not loaded with phosphates, homemade dextrose-only muffins, gummi bears, cakes etc.)

@happyhanneke

On his website, he links an article on
"Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch"
(energy-dependent and K+ influx activation).
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01768-5

Maybe someone would like to dig into this and report. There could be much more at play than an oversimplified assumption of glucose-sensing. Perhaps (re)stimulation of cell differentiation of those pericytes. Or (re)stimulation of their KATP expression. And perhaps CNS revascularization overall.

@ThinPicking said in Glucose loading cures everything?:

The Faustian chemist types are doing their own thing.

I can agree with this statement. After all, every single individual does and is ought to do her own thing.
I feel no need to debate that. "Faustian chemist types" made me chuckle a little. It seems you generally understood the groups I described as distinct subsets of a general population who never dabbled in self-experimentations of all sorts and who may thus have varying baselines to both the better and the worse.

@gentlepotato said in Glucose loading cures everything?:

100 x 5, or 20 x 5?

100gr x5. I.e. 500gr per day.