Posts made by Ecstatic_Hamster

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251293/

The subjects were given a one-ounce dispenser and advised to apply a thin layer once each morning to the areas of baldness. The formulation was made of a whole plant extract (CBD 60.00%, CBDV 12.63%, THCV 3.71%, delta 9 THC 0.18%, cannabigerol 0.86%, and cannabinol 0.05%). This hemp extract was independently analyzed by ACS Laboratory, Sun City Center, Florida. Each one ounce of the formulation contained active ingredients of 1 g of this hemp extract, 5 g of menthol, 600 g of peppermint oil-infused into a vehicle of 5 g of ethanol, 600 g of Emu oil and 14.9 g of Hexafluoroacetone (HFA) 134A (1,11,2-tetrafluoroethane) propellant, and 900 ml of dimethicone. The one-ounce foam spray or tincture lasted approximately 1 month on average. This is an average daily dose of 33 mg of topically applied hemp extract. The subjects were advised that they could use blow dryers, conditioners, and shampoos. The formulation was replaced as needed throughout the 6-month trial.

I can’t figure out how to easily post photos here. There are impressive before and after photos.

@zeal cabbage juice lowers thyroid activity.

@thyroidchor27 how sad!

There are so many wonders everywhere inside and outside. I’m not sure I understand the comic.

@mostlylurking said in Anyone with Ehlers Danlos and chronic pain flare ups find a solution?:

@Ecstatic_Hamster I was taking a higher dose of pregnenolone (around 200-225mg/day). However, my cholesterol spiked up and my normally sane endocrinologist threatened me with statins. So I cut my dose of pregnenolone in half and my cholesterol normalized within 6 months.

You may have to up it to a gram a day for this condition.
I can’t see why high cholesterol is a problem, frankly.

@peatyourmeat Maybe you are seeing through your own very dark glasses.

@Shar_to_the_dae why can’t you?

There are always ways.

Fish head soup works fine. If you can get them. Hard to dose, and of course it’s whole thyroid not T3.

Chicken necks with the thyroid still in is another bet.

I hate online chat for anything where you want to preserve your ideas and come back to them later.

Discord is like talk radio.

Forums are like collaborative papers we are writing together.

As far as platforms, I would host Matrix (whatever they are called these days) as it’s encrypted and secure and private.

@notmcas some people do well with up to 500mg or even more pregnenolone per day for Ehlers Danlos.

@notmcas i would try THC and CBD suppositories. Another thing to try is low dose naltrexone. Both could work very well.

https://www.nature.com/articles/1210641
Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228909
The tumor samples were classified according to the level of expression of CB1, CB2, or both. Patients with high expression levels of CB1, CB2, and CB1/CB2 showed increased survival reaching significance for CB1 and CB1/CB2 (p = 0.035 and 0.025, respectively). Both cannabinoid agonists inhibited the proliferation and expression of EGFR in lung cancer cells, and CBD potentiated the effect of THC. THC and CBD alone or in combination restored the epithelial phenotype, as evidenced by increased expression of CDH1 and reduced expression of CDH2 and VIM, as well as by fluorescence analysis of cellular cytoskeleton. Finally, both cannabinoids reduced the in vitro migration of the three lung cancer cells lines used.

Conclusions
The expression levels of CB1 and CB2 have a potential use as markers of survival in patients with NSCLC. THC and CBD inhibited the proliferation and expression of EGFR in the lung cancer cells studied. Finally, the THC/CBD combination restored the epithelial phenotype in vitro.

@brad it is a little tough to show more than anecdotal evidence but I will try.

https://www.sciencedirect.com/science/article/pii/S0753332222005984
this study tries to "sell" these tiny vesicles as a delivery mechanism to cancer, but it uses THC and CBD

this is kind of anecdotal on CBD
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559110/

https://www.sciencedirect.com/science/article/pii/S2667394022000120
CBD increases effectiveness of breast cancer therapies

THC in HER2-positive breast cancer
https://pubmed.ncbi.nlm.nih.gov/30733293/

The cannabinoid Δ9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL. This in turn triggers antitumor responses in vitro and in vivo. Selective targeting of CB2R transmembrane region 5 mimicked THC effects. Together, these findings define HER2-CB2R heteromers as new potential targets for antitumor therapies and biomarkers with prognostic value in HER2-positive breast cancer

and a review article
https://pubmed.ncbi.nlm.nih.gov/29390896/
the endocannabinoid-degrading enzymes fatty acid amide hydrolase and monoacylglycerol lipase, lipid transport proteins of the fatty acid binding protein family, additional cannabinoid-activated G protein-coupled receptors, members of the transient receptor potential family as well as peroxisome proliferator-activated receptors have been considered as targets of antitumoral cannabinoid activity. Therefore, this review focused on the antitumorigenic effects induced upon modulation of this extended endocannabinoid network.

low vitamin K2 MK4.

@buckminster said in Ray Peat was a Stalinist:

@Ecstatic_Hamster Here's the website 'Cell Intelligence' http://www.basic.northwestern.edu/g-buehler/htmltxt.htm

oh man, thank you thank you!

@lactose many times none. Or pain, a lump, it can be anything.

@pilky don’t see how to do that.

@gugenmungus thanks. Makes a lot of sense. People who get high fevers sometimes get rid of cancer. Sauna would be very good.

@George-Floyd your body catches up within a few days. I can’t imagine not taking thyroid. Can’t you get t3 somewhere you will be living.

As we age our skin loses cholesterol and we wrinkle when we tan. People who spend a lot of time in the sun often are very wrinkled for this reason. I find that using some lanolin on my skin helps replenish the cholesterol. I apply it at night. Lanolin is very high in cholesterol.

So I have studied this a lot.

I drink both excellent coffee and excellent tea.

Tea concentrates fluoride. The older the tea leaves used, the more fluoride gets concentrated.

When you pay for good quality tea, you are getting tea made from the tips, the shoots, and they are low in fluoride. If you buy cheap tea in the supermarket, it is very high in fluoride.

I think there are benefits to high quality tea. And I love tea. So I drink both coffee and tea all day long. I love the Japanese Gyukuro green teas, the Oolongs from Taiwan, and the amazing Keemun and Monkey teas from China.

You can also rinse the tea and discard the water, washing the tea, to get rid of stuff on the surface of the leaves.

We use loose teas only, of course, and use a Taiwan glass tea pot where we pour the water in. The top has a strainer on it.

You can also do what they often do in Asia. You can add tea leaves to a glass and add hot water, and avoid eating the tea leaves, and they just steep together and it’s simple. You can reuse and infuse the tea several times.

@gugenmungus would you mind summarizing? Thank you.