Posts made by Ecstatic_Hamster

@Himmler every single day. I take it off at night before bedtime. You wouldn't believe how much sensitivity increases after a few months.

@Alomongerpete said in Glucose Loading Protocol:

What's the purpose of this protocol? Expected benefits?

I'm taking it to avoid headaches.

The big issue with this is something that I noticed when I was doing the warrior diet.

You really can’t metabolize more than around 25 or 30 g of protein at a time.

So your protein may be too low if you’re doing only one protein meal.

And you’re loading yourself with a lot of protein at one time, which increases ammonia levels and stresses your kidneys.

We’re taking a 200 µg dose every other day be reasonable? It’s difficult to get anything but 200 µg dose.

@Living_thing it epigenetically changes cancer cells into normal cells. It literally gets rid of tumors.

When I hear "where is the mechanism" I have to sort of chuckle.

There are tons of papers on how THC fights cancer.

Did you know that every nerve cell in the body uses endocannabinoids to signal "stop--stop firing" to the nerve upstream of it that is firing?

And that we are floating on 20L of fluid, known now as a "new organ", the interstitium, fed by our lymphatic system?

https://www.nature.com/articles/1210641
Δ9-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers, which are often highly aggressive and resistant to chemotherapy. In this study, we characterized the effects of THC on the EGF-induced growth and metastasis of human non-small cell lung cancer using the cell lines A549 and SW-1573 as in vitro models. We found that these cells express the cannabinoid receptors CB1 and CB2, known targets for THC action, and that THC inhibited EGF-induced growth, chemotaxis and chemoinvasion. Moreover, signaling studies indicated that THC may act by inhibiting the EGF-induced phosphorylation of ERK1/2, JNK1/2 and AKT. THC also induced the phosphorylation of focal adhesion kinase at tyrosine 397. Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC. Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

I would get rid of my cancer in a month or two, using high dose THC administered via rectal suppositories. See CannabisHealthRadio.com for hundreds of similar stories.

I've personally interviewed many people who have used this remedy and completely gotten rid of even cancer where they were told they had weeks to live.

I would use ultrasound to monitor the tumor. Sometimes it shrinks and disappears. Other times it changes density and becomes normal again, instead of containing cancer cells. Sometimes this remedy doesn't work. Nothing works all the time, but it is probably 80% or 90% and it's not that expensive and it's very easy to do, and no high is required.

@Kilgore I am down to I'm sorry, down to 80g per day, I had written 40g in another post which is erroneous.

Anyway, I haven't seen any benefit that I can quantify or observe in 2 months at 200g - 340g per day. So I think it's a bust for me, but I'll continue on a maintenance regime and see if something develops.

I am down to 40g per day.

I didn't see any benefit after about 2 or 3 months. I mean, no benefit ever in that time.

I am not saying there won't be, but I am doubting it in my case, which is to fix chronic headaches.

I am experiencing some interesting and beneficial results from microdosing and lion's mane 'shrooms. But glucose loading may not be working for me personally.

I don't take iodine. I think Dr. Peat was right and it is generally not needed, and additional may suppress thyroid function.

it's not sugar.

It's glucose. That's part of sucrose but only part. Yes that's the protocol, start with 10g several times a day and build up to 300g or so in divided doses.

I don't take C routinely and I never really felt any benefit even with "heroic" doses that cause diarrhea. I do take it when I take aspirin, a few grams.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

This study shows that sarcosine lowers brain serotonin, while increasing GABA.

I took 500mg today. It was quite nice. My mood increased and my muscles looked fuller , also my skin and hair looked better . As if I had taken a big dose of collagen.
So far so good. It wasn't too exciting but it also wasn't sedating so actually a nice balance.

"Pretreatment of sarcosine (600 mg/kg, i.p.) non-significantly improved learning and memory deficits induced by non-competitive NMDA receptor antagonist MK-801, significantly increased the GABA and decreased the 5-HT levels (p<0.05)."
https://pubmed.ncbi.nlm.nih.gov/25710578/

thank you -- great find.

@Mauritio Sarcosine seems to be a mixed bag.

https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12439

DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells while decreasing their doubling time. Here, we show that incubation of prostate cells with sarcosine elicited the upregulation of sarcosine N-demethylation enzymes, sarcosine dehydrogenase and pipecolic acid oxidase. This process was accompanied by a considerable increase in the production of the major methyl-donor S-adenosylmethionine (SAMe), together with an elevation of cellular methylation potential. Global DNA methylation analyses revealed increases in methylated CpG islands in distinct prostate cell lines incubated with sarcosine, but not in cells of nonprostate origin. This phenomenon was further associated with marked upregulation of DNA methyltransferases (Dnmts). Epigenetic changes were recapitulated through blunting of Dnmts using the hypomethylating agent 5-azacytidine, which was able to inhibit sarcosine-induced migration of prostate cells. Moreover, spatial mapping revealed concomitant increases in sarcosine, SAMe and Dnmt1 in histologically confirmed malignant prostate tissue, but not in adjacent or nonmalignant tissue, which is in line with the obtained in vitro data. In summary, we show here for the first time that sarcosine acts as an epigenetic modifier of prostate cells and that this may contribute to its oncometabolic role.

@Sippy I don't know. But I would probably try it. Dr. Stephens may actually reinforce this, who knows, because he has used it apparently with people who had all sorts of brain issues. He really points to all problems as originating in the brain, resulting in hyperglycolysis, resulting in throttling of glucose, resulting in...all sorts of mental illness and issues. So yeah. Yeah. And I can't see how it would cause harm.

methionine restriction is good. Also consuming methioninease is better. The enzyme which is present in many animals and molds, is now patented and very expensive, but it can result in a tumor completely disappearing as it gets rid of almost all methionine.

@CrumblingCookie that is a huge dose of folate.

I’m at 70g four times daily. Taking with potassium rich beverage. Gained a few pounds. Maybe just water weight. My temperatures are not any different. I am working to reduce headaches, and I think they are reduced, but they are not gone. Still hopeful.

I’ve not been that impressed with rapamycin personally, as it gives me a headache and interferes with sleep.

But low dose naltrexone and deprenyl are quite amazing and are great longevity drugs. LDN in particular has made a huge different for so many people as it can seal leaky gut — which is the source of virtually all chronic disease as we age.

@GRay carbonic anhydrase inhibitors and beta blocker drops are safest. Prostaglandin drops not so much. The “drops” I make work through carbonic anhydrase inhibition. My loved one had a laser iredectomy but it isn’t enough. Not sure it is actually useful.

tea is very high in fluoride. The more expensive teas are harvested from young shoots, which are much lower in fluoride due to less time growing to accumulate it. But that is the issue, the cheaper assam teas can have 2mg per cup.