Posts made by GRay

@Mossy said in StressNon dose/route of administration?:

t's hard for me to always follow these principles with proper understanding, but how are you concluding that the dissolved in SFA pregnenolone was oral and not topical and that it is now 10:1? By the fact that it will bypass first metabolism in the liver?

I found the 10:1 rule on the older forum, and it was in the topical route, but as it was mentioned in the video with Mercola and Haidut, Preg dissolved in long chain SFA will by pass first pass metabolism, same way it does when applied topically.

However, I have decided to try again a micronized pregnenolone orally, as I think it may be the best delivery method for Pregn. Even Peat was taking Pregnenolone this way

In one of the articles of Ray Peat, he mentions that powered Pregnenolone is absorbed fairly well, do we know how much is actually bioavailable in the micronized form? I made a research but I was unsuccessful in finding this info.

He mentions the body at the age of 30 produces 30/50mg, and wondering what this would translate in mg of Micronized Pregnenolone

@Mossy thanks. Sorry the late response, as I was not notified about it.

I have read this before. However, it is a bit confusing with what Haidut says, as in the text you attached, he mentions that there is no advantage of taking oral stressNon, but then in a video interview with Dr Mercola, he mentions how pregnenolone dissolved in SFA will bypass first metabolism in the liver, that means a 5mg dose of Pregnenolone will be almost 100% bioavailable, so theoretically when it is taken orally, the rule 10:1 can still be applied in this case.

What is more confusing is that he mentions that a oral dose for full replacement is 30/50mg, and I assume orally with first pass metabolism, but with stressnon could probably be 3/5mg then.

However, when someone is very low on Pregnenolone, 100mg of oral micronized Preg, generally takes levels to mid range.

Hi Guys, I'm also moving from the ex RPF

There is an extensive thread over there about the Idea Labs Pregnenolone. However, the more I read, and the more I listen to Georgi videos with Mercola on the topic, the more I scratch my head on dosing, and route of administration.

On the thread @haidut mentions that the ideal dose of Pregnenolone is 30/50mg, or below 100mg, considered as a oral powdered form.

Using StressNon topically, when Preg was dissolved in DMSO, FEMA or Eugenol, 100mg oral Preg = to 10mg of StressNon, However, since the change in the SFA/anhydrol there was not any more comments on the bioavailability of the product, can anyone confirm is the same?

Oral route: I head Georgi and Mercola talking about dissolving Pregnenolone and DHEA in long chain FA so that it will by pass first pass metabolism when ingested. If this is true, then I would expect to use same dosing as topical, such as 3/5mg to get the ideal dose of Preg. Does that make sense? is anyone using it orally?