Topics created by haidut

@haidut it’s funny how most of the k2 studies youve posted recently are of mk7 🙂

@yerrag
Yes, although this study shows rapamycin has thymus weight lowering effect in mice. Although there was clearly a dose dependant effect and the HEDs were like 15-60mg per day which is really high, so I'm not sure if there would be any such effect if you were to take just 1-5mg / week .
So the weekly dose of this study was about 30-100 times higher than what most humans take.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9360838/

@gg12 said in The benefits of smoking, if any, may be due to lowering endotoxin and estrogen:

@yerrag
I dont know your case at all but I do know that people with sleep apnea caused by small jaws and tongue ties due to improper development have low spo2 levels at night and often have lots of issues as there tongue falls back in thier thoat at night blocking air waking them up giving them a big shot of adrenaline so they cant fall back asleep. Also you cant breath as much air when your airway is obstructed by small jaws.
To fix this do palate expansion then tongue tie release then jaw surgery
Look up "jawhacks " on youtube to learn more its a silent epidemic
Not the ay peat perspective but just something I wanted to share that mainsteam health doesn't talk about

I guess you merely scanned my post and missed the part about my lungs becoming edematous being one of two causes my spO2 levels are low. But sleep apnea from obstruction isn't my condition which actually mainstream medicine would point to as a kneejerk response to low spO2 levels during sleep.

I'm not sure what a Peaty explanation to low spO² levels while sleeping is, but I think it would go along the lines of low serum CO2 levels (from poor sugar metabolism) and accompanying high serum acidity from high lactic acid would lead to high breathing rates while asleep, as the respiratory center attempts to correct the high acidity by trying to breathe out CO2 when there really isn't enough serum CO², leading to further lower tissue oxygenation and hypoxia. This. causes the body to have to use the mouth to breathe in addition to the nose, and causes snoring to happen, in an attempt to get more oxygen even while the blood is already carrying enough oxygen already. Even when spO2 levels are high at 99%, people can still snore because the oxygen in blood isn't getting through to the tissues due to low serum CO2.

@haidut I suspect that 5-HT is high in babies because constipation/impaction of the gut would be life threatening for a baby. 5-HT keeps things moving along in the intestine; it increases/intensifies peristalsis.
Serotonin Deficiency Is Associated With Delayed Gastric Emptying

I suspect that the issue of serotonin (5-HT) getting through the intestinal wall and into the blood stream is the primary concern; so long as the 5-HT remains inside the intestine (along with the endotoxin) things should be fine. If the integrity of the intestinal wall is compromised and endotoxin and 5-HT are able to seep through into the blood stream major problems happen (sepsis, high serotonin symptoms).

The health of the epithelial cells that line the intestine are important because if they fail, leaky gut happens. Thiamine is believed to be important for the epithelial cell function. See here: Dietary supplementation of thiamine enhances colonic integrity and modulates mucosal inflammation injury in goats challenged by lipopolysaccharide and low pH "The results show that dietary thiamine supplementation could improve the colon epithelial barrier function and alleviate mucosal inflammation injury in goats after lipopolysaccharide and low pH challenge."

Another important body part that requires excellent epithelial cell function is the blood/brain barrier. Thiamine deficiency compromises the blood/brain barrier too.

Thanks for all you do! I always appreciate your posts.

@haidut is leucomethylene blue safe to take? It is what is left over after turning ascorbic acid ----> dehydroascorbic acid with MB. You've said before the mixture can be left out after the LMB and DHAA are produced and the LMB will oxidize back to MB, yet I'm unsure if the DHAA degrades in the meantime. I've thought of bubbling air back into the solution to get it to go blue again. And then again, I have the suspicion that the redox state of MB/LMB is pretty much inconsequential as it cycles between the forms relatively rapidly once ingested. My urine still changes color wether I take MB by itself or LMB + DHAA.

I like taking it during winter.

@Mr-X Not sure. I have not taken it by itself. I take the stack I posted morning and evening.

Positives I’ve Noticed:

More calm Feel less intimidated/scared by higher ranks in my work place less social anxiety. Used to freeze during presentations and driving meetings. no adrenaline rush (interesting feeling when I went on a rollercoaster. It was like experiencing the ride with clear vision. No fear.) feel more drive to perform well in my workplace

Negatives

Occasional dry eyes. Occasional catching myself acting confident in a rude manner, but no anger. Not afraid to speak my mind or filter my thoughts before speaking. when the stack starts wearing off, i feel like the stress response flicks on and off rapidly during a stressful event. For example, when I was riding my motorcycle I got stressed when I was trying to come off the line. While I was peeling away the feeling of stress would turn on and off repeatedly until I felt safe on my way. Weird feeling.

Neutral effects

I feel full all the time even with little food weight gain but it doesn’t feel like fat. Clothes fit the same. Hoping the drop in cortisol and serotonin is allowing some muscle to grow back.

@calvinklein21101 said in Vitamin A may prevent/treat motor neuron diseases, including the lethal ALS:

something going wrong in their metabolism

I read Poisoning for Profits and my first inclination wasn't to start rattling on about my liver while chomping rice and beans all day. Something about it seems to ring with them.

Relevant for many and thank you as always.

This info will be passed on.

@haidut said in Pregnenolone (P5) may treat for COVID-19, by increasing dopamine:

Given that the mechanism of action reported by the study (dopamine enhancement) is so generic, the findings of the study possibly apply to other respiratory viral infections (URTI) too

Dopamine was quite important in renal function the last time I checked, renal function quite important to the RRAS, the RRAS quite important to the "spike protein" (an ACE2 inhibitor, allegedly).

It's highly likely to me that it does apply to other URTI. In which case I wonder why we're using the word "covid". Other means to walk believing masses back are available.

Thank you for sharing this interesting new angle. It fits very well with the recent interest in the connection between antibiotics and AD. In the last three years, several large studies looking at the efficacy of antibiotics have been started, and they should probably yield some very interesting results. In the end, it all comes down to your gut and endotoxins.

@haidut Your work is much appreciated! What do you think of using ALCAR (Acetyl-L-carnitine) to raise dopamine? From personal experience it seems to be able to do this on an empty stomach.
Here is one study -that begs the question what kind of electrical sim were they using?:

Effect of acetyl-L-carnitine on the dopaminergic system in aging brain

*Abstract

We studied the effect of acetyl-L-carnitine (ALCAR) on dopamine release and the effect of long-term acetyl-L-carnitine treatment on age-related changes in striatal dopamine receptors and brain amino acid levels. In striatal tissue that had been incubated with [3H]dopamine, acetyl-L-carnitine increased the release of [3H]dopamine evoked by electrical stimulation. In striatal tissue from aged mice administered acetyl-L-carnitine for 3 months, the release of [3H]dopamine evoked by electrical stimulation was higher than that of its aged control; the release after a second stimulation was similar in the two groups. There was a significant decline in the number of D1 striatal dopamine receptors with age. The Bmax was 51% lower in 1.5-year-old mice than in 4-month-old animals. Administration of acetyl-L-carnitine for 3 months diminished the reduction in the binding of [3H]SCH-23390. [3H]Spiperone binding to D2 receptors was not decreased with age and was not affected by acetyl-L-carnitine treatment. Age-related decreases in levels of several amino acids were observed in several brain regions. Acetyl-L-carnitine lessened the reduction in the level of taurine only in the striatum. The findings confirm the multiple effects of acetyl-L-carnitine in brain, and suggest that its administration can have a positive effect on age-related changes in the dopaminergic system.*

I think this lines up generally with PUFAs/increased serotonin/increased cortisol being associated with ASD (autism spectrum disorder) symptoms. Very nice that you keep collecting these studies!

Not specifically related to PUFA, but more to the endotoxin part, I have noticed that a lot of people I know with ASD have somewhat of a "pot belly". The evidence here is of course anecdotal, but I was wondering if this could be bloatedness associated precisely with endotoxin? The correlation with increased bacterial activity in the gut seems likely via the serotonin/cortisol connection in people with ASD, and I guess increased bacterial activity could lead to bloating. It would also line up with what you have mentioned for long distance runners in this connection, the "subclinical Cushing's disease", if I'm not mistaken.

Could you kindly comment if you consider this makes sense? Much appreciated!

interesting

do you agree with this tier list?

https://bioenergetic.forum/topic/2838/protein-tier-list

@haidut
Interesting. I looked for success markers along the stated timeframe of 6 months in the study's full text but the authors did not disclose any details.
Would be great to contact them and ask if anybody here would be so forthcoming?
As in: How was the success measured and did those measures improve gradually or was it switch-like at about 6 months or earlier?

Has anybody looked into this 2021 study from Hungary below?

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392034/

They argue for a complex system of energy depletion, mitochondria dysfunction and also a polyamine depletion (by expulsion) for the crucial spermidine levels in neurons in combination with odd stress signalling patterns. There could be a unique case for spermidine supplementation.
And the participation of a long-term manifestation of changes in the endocannabinoid and opioid system.
And much more.
For some odd reason there even seems to be succesful, positive interaction between hCG injections and spermidine and POIS?

By the authors' establishing ties of a common multifactorial pathogenesis between POIS and delayed onset muscle soreness I wonder whether either of these two are 'special' manifestations of a general CFS, mitochondrial, energy, neuronal, autonomic dysfunction.

Good post 👍

https://raypeatforum.com/community/threads/war-is-coming-in-2024-be-prepared.52436/post-999500

For anyone researching the related topics of myopathy, muscle weakness/endurance, NAD and lactate, be sure to check out the RP forum for more info. There you'll find info on how Thiamine and especially Niacinamide can be helpful.