Topics created by haidut

@haidut said in Niacinamide improves bone health and reduces fat synthesis:

Two of the features of aging thought to be unavoidable are brittle bones and increased visceral fat, both of which (alone or in combination) are a major contributing factor for the increased mortality seen with aging. As it turns out, both these features are apparently driven by decline in metabolism/OXPHOS, which is driven primarily by a relative NAD+ deficiency (i.e. low NAD+/NADH ratio), and supplementation with NAD+ precursors such as niacinamide may be able to stop/reverse them.

https://www.xiahepublishing.com/2835-6357/FIM-2023-00046

https://www.eurekalert.org/news-releases/1054674

“…Recent studies indicate that oxidative phosphorylation plays a critical role in osteogenesis, the process by which new bone is formed. During osteogenic induction, cells shift their energy metabolism from glycolysis to mitochondrial oxidative phosphorylation, increasing respiratory enzymes, mitochondrial DNA copy number, oxygen consumption, and intracellular ATP content​. Bone morphogenetic protein 2 (BMP2) has been shown to trigger metabolic adaptations in mesenchymal stem cells (MSCs), characterized by successive activation of glycolysis and oxidative phosphorylation​. NAD+ levels and the NAD+/NADH ratio are crucial for mitochondrial function, linking cellular metabolism to transcriptional events and signaling pathways. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, promotes osteogenesis and reduces adipogenesis in MSCs, protecting bone from aging and damage.”

Via: http://haidut.me/?p=2604

Niacinamide and Weight Loss: Niacinamide Has Striking Antiobesity Effects

https://www.onedaymd.com/2022/07/low-dose-niacinamide-has-striking.html

@Ecstatic_Hamster 🙂

I saw on rpf someone mentioned majority gamma is the main one to be aware to supplement for tobacco smokers.

do you think famotidine is superior to cyproheptadine to keep in the medicine cabinet?

Hello, Jorge (or your bot).

That these vitamins increase the risk of cancer complications is not a reason to avoid supplementation, but to be more cautious with them.

One suggestion was to offer B-vitamins in separate products, something like:

Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways

But it's challenging to have a clear separation of vitamins because of interrelationships. Pyridoxin was excluded from their 'energy metabolism' group, but it's directly involved in glycogen use and the transaminases to prepare amino acids for oxidation. Biotin was included, but associated with anabolic functions, and one of the catabolic pathways would be dependent on the vilified (adenosyl)cobalamin. If all came down to an energy problem, the nucleotides of the energy-releasing coenzymes involve folate in their syntheses.

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

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Growth-promoting substances don't just fuel cancer, they're also needed for cell and tissue regeneration.

Supplementation is discouraged for folate, cobalamin, and choline (or betaine). We know that the message is reaching a community that doesn't consume a lot of leaves (foliage→folate), nor legumes. The availability of folate in oranges is arguably lower than expected.

Properties of Food Folates Determined by Stability and Susceptibility to Intestinal Pteroylpolyglutamate Hydrolase Action

Tipping the reliance in favor of folate-cobalamin over choline might yield extra glycine, that can be formed for every folate cycled. The simultaneous restriction of these vitamins, along with a predisposition to their insufficiency, malabsorption syndromes, and the adoption of a diet low in methionine doesn't seem promising.

Do we have indications that the population is adequate in the anabolic vitamins and can afford a restriction? Because the typical consumption and positive reactions to supplementation suggest otherwise.

Not only a deficiency of any vitamin tends to predispose to cancer, but cancer is not the only disease to worry about. Cardiovascular problems and infections are major threats.

Digestion weakens in advanced age and disease, making it helpful to have available these vitamins in purified form. The issue here is that you're leaving for other vendors to do the dirty job of guaranteeing adequacy in a considerable number of people that would benefit from the carcinogenic nutrients.

@haidut 👍 😊 👏 thank you

Just my simplified take on arthritis, as more and more I am swayed to think that there is only arthritis, and that arthritis is caused by low metabolism, and very much so because CO2 deficiency from low mitochondrial metabolism makes the ecf acidic, enough so that some salts, urate salts being one, precipitate, and cause the formation of crystals that cause wear and tear on our joints.

I profess ignorance though, on the matter of the different forms of arthritis, as when I attempt to understand the different forms of arthritis, the explanations given in the literature always lead to draw blanks, which makes me either an embecile thet fails to comprehend or simply that the literature is just playing on words and terms that give different names to a banana. The added complexity is a ploy to distract from the one true cause of arthritis, if I may dare say so.

Which is why Ray points to hypothyroid as the cause of arthritis, which I first thought of as a rather simplistic explanation. But if I can relate to cause and effect, and dig deeper into it, it is not as complicated as it appears to be.

The key is acid base balance. As simple as that. When we have an abundance of CO2 because our body makes a lot of it at our disposal, we have the best pH buffer available for our lungs and kidneys to manage acid base balance. When alkaline, it can turn into an acid called carbonic acid, and when acidic, CO2 can turn into bicarbonate. This is based on Le Chatelier's principle, where the direction of a reaction is in the direction of the stress that it relieves.

What better way to provide a surfeit of CO2 in our body than to be producing energy using mitochondrial oxidation. Vitamin B1 is a crucial link in a chain of nutrients and substances and processes that enable mitochondrial oxidation. Simply being deficient in one link makes rhe chain broken, and a broken chain only leads to low metabolism, and the resulting imbalance in pH, usually acidic, will just cause the formation of salt crystals that irritate and inflame and destroy tissues.

I know enough how to monitor my acid base balance, so I know what remedial actions to take to keep my acid base balance from being chronically in an imbalanced state. Many bad things happen in a chronic state of acid base imbalance.

I have high uric acid, yet I don't have any arthritis, much less gout. Only because my optimal acid base balance keeps uric acid crystals from forming.

I don't have tachycardia (high heart rate) because my heart muscle pumps well and isn't strained because the muscle contracts and relaxes effortlessly because of good acid base balance.

I don't fear cancer because I believe that an acidic ecf is what causes regulatory and harmless and commensal microbes to turn into virulent parasites that cause cancer to develop.

Yes, vitamin B1 is important, but such studies are subordinate to putting all the pieces of rhe puzzle together to form a whole picture. This is where we need work on, as without this perspective one can end up taking one supplement after another and not progressing from his poor state of health.

Makes sense when B1 is needed for mitochondrial respiration, but not the only one needed.

@haidut thank you

Makes sense to me, but surely not alone HaidutBot.

It's almost old hat now, people referring to the gut as a 'second brain'. And sure enough, I could send myself to a psychologically uncomfortable place simply by eating orange peel (for example).

And allegedly there's another stop on the axis.

@ThinPicking said in Are Polls a Good Idea?:

https://www.mdpi.com/1424-8220/22/23/9115
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075501/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002343/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.040499
https://www.sciencedirect.com/science/article/abs/pii/S0306987719307145
https://www.sciencedirect.com/science/article/pii/S1568163721002865
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00278/full

@haidut
I had also read your previous post on that 300mg-biotin-per-day study and can attest by my own experience that there really are things opening up at thrice daily doses of about 100mg B7.
Practically, however, I ran into a few issues. What are your opinions on these?

Biotin:

I don't understand how study participants could cope for so long with such high doses, since B7 competes with B5 for uptake? Especially with regard to restoration of myelin sheaths, cell membranes and endogenous fatty acid synthesis they are both interdependent. I kept running into deficiency of one or the other and had to alternate both at least once every few days. I felt that at such high doses, purity and fillers really become a significant issue. I've tried different brands because of this and they ranged from awful (with excessively much MCC) to something-is-still-off. Pharmaceutical quality in general is only >97.5% purity which by itself I consistently find totally inadequate in many cases. Perhaps related to 2). My GI system and BMs became unbearably upset by high biotin doses. I suspect biotin exhibits inhibiting effects on aminooxidases similar to thiamin (thiamin metabolites) through displacement of enzymatic flavoproteins? I'm convinced much of the beneficial effects in Antonio Costantini's high-dose-thiamin therapy stems from MAO inhibition in the ganglions.

Riboflavin:

Are such high bolus doses really sensible in people who are unaffected by that recognized genetic riboflavin transporter defect?
.1) I have noticed much better effects and tolerability from single digit mg doses continually (3-4x) throughout the day instead of higher doses twice or once daily.
.2) Someone on the forums reported to have had his actual serum/blood FAD and FMN levels tested with different amounts of B2 and that their ratio and the absolute value of FAD totally plumetted from high doses of B2, whereas FAD and also his symptoms improved with low doses.

Side note: I have used B2 in amounts up to 2grs for clostridioides prophylaxis because of the studies on its redox effects and the aerobic-anaerobic gradient of the intestinal lining and its microbes. While such amounts are probably really not harmful, they made for purging and very awful BMs.

Hope you are doing well! And thanks for all the work!

@haidut 👏 👍 😊

@cs3000 said in Microplastics – known endocrine disruptors- found in blood, gonadal organs:

@Mauritio pectin interaction
https://phys.org/news/2022-06-interaction-nanoplastics-pectin-water-soluble-polysaccharide.html
https://www.sciencedirect.com/science/article/abs/pii/S2213343722009277

https://www.tandfonline.com/doi/full/10.1080/10643389.2023.2195798#d1e1308
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312509/

Thanks that's awesome.

Apples for the win (again).
And the amount was pretty small as well at 15mg/L .

"...ingested MPs can pass through the gut barrier, be translocated through the systemic circulation, and accumulate in distant tissues including the brain, liver, and kidney."
That's pretty concerning though. And I don't know if pectin would help with micro plastics once it has accumulated, since pectin doesn't absorb and should only take care of the MP that is present in the stomach or gut as long is it's present.

Maybe modified citrus pectin (MCP) would be a better option in that case because it actually does absorb.

@Jakeandpace
Yes I do now. It definitely makes a difference.

I'm just concerned to suggest it to someone else with masses in his colon that shouldn't start bleeding. I read in previous studies that aspirin does not cause bleeding but for me this definitely was the case.
This family member is really in a bad state so I'm not sure if it's even worth it anymore.

@LiftWaffe88 Your favorite painter would have presided over the same purported degeneration in the populace which is why i find your comment really funny against the backdrop of your banner and forum persona.